Multiple Eruptive Dermatofibromas Masquerading as Cutaneous Lymphoma

A 34-year-old male came with complaints of multiple firms to hard nontender, nonitchy nodules, measuring 2 cm × 2 cm to 1 cm × 1.5 cm, present predominantly over the lower limbs. This condition started 5 years back as a single nodule over the thigh but gradually increased in number and size with time to involve both lower limbs. A differential diagnosis of cutaneous lymphoma and dermatofibroma was considered. He underwent a biopsy and immunohistochemistry for the same which were consistent with hemosiderotic histiocytoma and positive for vimentin. The patient was advised surgical excision for the same. The occurrence of multiple dermatofibromas although rare has been reported in a few case reports; however, the occurrence of multiple dermatofibromas of the hemosiderotic variant has not been documented yet.

[1]  D. Cardona,et al.  Immunohistochemical Markers in Fibrohistiocytic Lesions: Factor XIIIa, CD34, S-100 and p75 , 2014, The American Journal of dermatopathology.

[2]  M. Pusztaszeri,et al.  Giant Hemosiderotic Dermatofibroma: A Case Report and Review of the Literature , 2011, Case Reports in Dermatology.

[3]  C. Mignogna,et al.  Hemosiderotic Dermatofibroma: Report of One Case , 2006, Dermatology.

[4]  J. Malvehy,et al.  Dermoscopic findings of haemosiderotic and aneurysmal dermatofibroma: report of six patients , 2006, The British journal of dermatology.

[5]  Jean Kanitakis,et al.  Multiple eruptive dermatofibromas in a patient with HIV infection: case report and literature review , 2000, Journal of cutaneous pathology.

[6]  F. Nestle,et al.  Dermatofibroma: an abortive immunoreactive process mediated by dermal dendritic cells? , 1995, Dermatology.

[7]  H. Iwasaki,et al.  Dermatofibroma: Superficial fibrous proliferation with reactive histiocytes–a multiple immunostaining analysis , 1994, Cancer.

[8]  A. Carbone,et al.  Dermatofibroma: superficial fibrous proliferation with reactive histiocytes--a multiple immunostaining analysis. , 1994, Cancer.

[9]  R. Sánchez.  The elusive dermatofibromas. , 1990, Archives of dermatology.

[10]  C. Mattacks,et al.  DERMATOFIBROMAS AND ARTHROPOD BITES: IS THERE ANY EVIDENCE TO LINK THE TWO? , 1989, The Lancet.

[11]  T. Robinson,et al.  Cryotherapy for dermatofibromas , 1987, Clinical and experimental dermatology.

[12]  H. Bargman,et al.  Multiple dermatofibromas in a patient with myasthenia gravis treated with prednisone and cyclophosphamide. , 1986, Journal of the American Academy of Dermatology.

[13]  L. Shapiro,et al.  Multiple histiocytomas. Report of a case. , 1970, Archives of dermatology.

[14]  C. Romaguera,et al.  [Multiple histiocytomas]. , 1959, Actas dermo-sifiliograficas.