Multiple Effects of Prefrontal Lesions on Task-Switching

This study examined the performance of 41 patients with focal prefrontal cortical lesions and 38 healthy controls on a task-switching procedure. Three different conditions were evaluated: single tasks without switches and two switching tasks with the currently relevant task signalled either 1500 ms (Long Cue) or 200 ms (Short Cue) before the stimulus. Patients with Superior Medial lesions showed both a general slowing of reaction time (RT) and a significantly increased switch cost as measured by RT. No other prefrontal group showed this increased reaction time switch cost. Increased error rates in the switching conditions, on the other hand, were observed in patients with Inferior Medial lesions and, to a lesser extent, ones with Superior Medial lesions. Patients with left dorsolateral lesions (9/46v) showed slower learning of the task as indicated by a high error rate early on. Several different processes are involved in task-switching and these are selectively disrupted by lesions to specific areas of the frontal lobes.

[1]  S. Monsell,et al.  Costs of a predictible switch between simple cognitive tasks. , 1995 .

[2]  John R. Anderson,et al.  The role of prefrontal cortex and posterior parietal cortex in task switching. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[3]  I Biederman,et al.  Human performance in contingent information-processing tasks. , 1972, Journal of experimental psychology.

[4]  N. Meiran,et al.  Component Processes in Task Switching , 2000, Cognitive Psychology.

[5]  D Y von Cramon,et al.  Executive control functions in task switching: evidence from brain injured patients. , 1999, Journal of clinical and experimental neuropsychology.

[6]  I. Radermacher,et al.  Functional anatomy of intrinsic alertness: evidencefor a fronto-parietal-thalamic-brainstem network in theright hemisphere , 1999, Neuropsychologia.

[7]  R. Cabeza,et al.  Frontiers in Human Neuroscience , 2009 .

[8]  B. Milner.  Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes , 1963 .

[9]  T. Shallice,et al.  Qualitatively different memory impairments across frontal lobe subgroups , 2007, Neuropsychologia.

[10]  R. Poldrack,et al.  Cortical and Subcortical Contributions to Stop Signal Response Inhibition: Role of the Subthalamic Nucleus , 2006, The Journal of Neuroscience.

[11]  Stephen Monsell,et al.  Can the task-cuing paradigm measure an endogenous task-set reconfiguration process? , 2006, Journal of experimental psychology. Human perception and performance.

[12]  Brian Levine,et al.  Fractionalization and localization of distinct frontal lobe processes: Evidence from focal lesions in humans , 2002 .

[13]  Tim Shallice,et al.  Functional imaging and neuropsychology findings: how can they be linked? , 2003, NeuroImage.

[14]  D. Norman,et al.  Attention to action: Willed and automatic control , 1980 .

[15]  C. Umilta,et al.  Attention and Control Deficits Following Closed Head Injury , 1994, Cortex.

[16]  K. A. Hadland,et al.  Role of the human medial frontal cortex in task switching: a combined fMRI and TMS study. , 2002, Journal of neurophysiology.

[17]  Jason B. Mattingley,et al.  Executive “Brake Failure” following Deactivation of Human Frontal Lobe , 2006, Journal of Cognitive Neuroscience.

[18]  Erik M Altmann,et al.  Repetition priming in task switching: Do the benefits dissipate? , 2005, Psychonomic bulletin & review.

[19]  Nachshon Meiran,et al.  Modelling cognitive control in task switching and ageing , 2001 .

[20]  A. Dove,et al.  Prefrontal cortex activation in task switching: an event-related fMRI study. , 2000, Brain research. Cognitive brain research.

[21]  Malcolm A Binns,et al.  Dissociations within the anterior attentional system: effects of task complexity and irrelevant information on reaction time speed and accuracy. , 2002, Neuropsychology.

[22]  D. Neary.  Lesion Analysis in Neuropsychology , 1990 .

[23]  Nachshon Meiran,et al.  The Cerebellum Mediates Conflict Resolution , 2007, Journal of Cognitive Neuroscience.

[24]  T. Robbins,et al.  Dissociating executive mechanisms of task control following frontal lobe damage and Parkinson's disease. , 1998, Brain : a journal of neurology.

[25]  R. A. Carlson,et al.  Procedural frameworks for simple arithmetic skills , 1998 .

[26]  Hilde Haider,et al.  Preparatory processes in the task-switching paradigm: evidence from the use of probability cues. , 2002, Journal of experimental psychology. Learning, memory, and cognition.

[27]  T. Shallice,et al.  A Multidisciplinary Approach to Anterior Attentional Functions a , 1995, Annals of the New York Academy of Sciences.

[28]  H. Karnath,et al.  Using human brain lesions to infer function: a relic from a past era in the fMRI age? , 2004, Nature Reviews Neuroscience.

[29]  M. Walton,et al.  Interactions between decision making and performance monitoring within prefrontal cortex , 2004, Nature Neuroscience.

[30]  N. Meiran.  Reconfiguration of processing mode prior to task performance. , 1996 .

[31]  T. Robbins,et al.  Planning and spatial working memory following frontal lobe lesions in man , 1990, Neuropsychologia.

[32]  M. Brass,et al.  Advance preparation and stimulus-induced interference in cued task switching: further insights from BOLD fMRI , 2005, Neuropsychologia.

[33]  T. Robbins,et al.  A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex. , 2004, Brain : a journal of neurology.

[34]  P. Elsass,et al.  Reaction time and brain disease: relations to location, etiology and progression of cerebral dysfunction , 1985, Acta neurologica Scandinavica.

[35]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[36]  R. Passingham,et al.  Reading Hidden Intentions in the Human Brain , 2007, Current Biology.

[37]  T Shallice,et al.  Impaired concentration due to frontal lobe damage from two distinct lesion sites , 2005, Neurology.

[38]  D. Stuss,et al.  Is there a dysexecutive syndrome? , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[39]  T. Robbins,et al.  Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans , 2003, Nature Neuroscience.

[40]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[41]  Marcel Brass,et al.  When the same response has different meanings: recoding the response meaning in the lateral prefrontal cortex , 2003, NeuroImage.

[42]  H. Garavan,et al.  Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction , 2002, NeuroImage.

[43]  T. Shallice,et al.  Task Switching : A PDP Model , 2001 .

[44]  Jeremy R. Reynolds,et al.  Neural Mechanisms of Transient and Sustained Cognitive Control during Task Switching , 2003, Neuron.

[45]  Marcel Brass,et al.  Selection for Cognitive Control: A Functional Magnetic Resonance Imaging Study on the Selection of Task-Relevant Information , 2004, The Journal of Neuroscience.

[46]  G. Logan,et al.  Clever homunculus: is there an endogenous act of control in the explicit task-cuing procedure? , 2003, Journal of experimental psychology. Human perception and performance.

[47]  Erik M Altmann,et al.  Advance Preparation in Task Switching , 2004, Psychological science.

[48]  R De Jong,et al.  An intention-activation account of residual switch costs , 2000 .

[49]  N. Cohen,et al.  General and task-specific frontal lobe recruitment in older adults during executive processes: A fMRI investigation of task-switching , 2001, Neuroreport.

[50]  Hans-W. Müller-Gärtner,et al.  Systems level modeling of a neuronal network subserving intrinsic alertness , 2006, NeuroImage.

[51]  D. Alan Allport,et al.  SHIFTING INTENTIONAL SET - EXPLORING THE DYNAMIC CONTROL OF TASKS , 1994 .

[52]  I. Biederman,et al.  Mental set and mental shift revisited , 1976 .

[53]  T. Shallice,et al.  Response suppression, initiation and strategy use following frontal lobe lesions , 1996, Neuropsychologia.

[54]  D. Stuss,et al.  The effects of focal anterior and posterior brain lesions on verbal fluency , 1998, Journal of the International Neuropsychological Society.

[55]  Jordan Grafman,et al.  The Roles of Timing and Task Order during Task Switching , 2002, NeuroImage.

[56]  Nachshon Meiran,et al.  Advance task preparation reduces task error rate in the cuing task-switching paradigm , 2005, Memory & cognition.

[57]  T. Shallice,et al.  Multiple frontal systems controlling response speed , 2005, Neuropsychologia.

[58]  Jonathan D. Cohen,et al.  Conflict monitoring versus selection-for-action in anterior cingulate cortex , 1999, Nature.

[59]  E. Rolls.  The functions of the orbitofrontal cortex , 1999, Brain and Cognition.

[60]  B. Leupen,et al.  Design and analysis , 1997 .

[61]  D. Stuss,et al.  Wisconsin Card Sorting Test performance in patients with focal frontal and posterior brain damage: effects of lesion location and test structure on separable cognitive processes , 2000, Neuropsychologia.

[62]  H. Haider,et al.  Preparatory processes in the task-switching paradigm: evidence from the use of probability cues. , 2002 .

[63]  W. Gehring,et al.  Medial Frontal Cortex Activity and Loss-Related Responses to Errors , 2006, The Journal of Neuroscience.

[64]  Donald A. Norman,et al.  Attention to Action , 1986 .

[65]  G. D. Logan.  Task Switching , 2022 .

[66]  B. Hommel,et al.  Task-switching and long-term priming: Role of episodic stimulus–task bindings in task-shift costs , 2003, Cognitive Psychology.

[67]  D. Pandya,et al.  Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns , 1999, The European journal of neuroscience.

[68]  F. Dick,et al.  Voxel-based lesion–symptom mapping , 2003, Nature Neuroscience.

[69]  K. Berman,et al.  Fractionating the neural substrate of cognitive control processes , 2002, Proceedings of the National Academy of Sciences of the United States of America.