Cardiovascular and cerebrovascular physiological measurements in clinical practice and prognostics in geriatric patients

[1]  R. Kenny,et al.  Outcome of an integrated approach to the investigation of dizziness, falls and syncope in elderly patients referred to a 'syncope' clinic. , 1993, Age and ageing.

[2]  Rose Anne Kenny,et al.  Continuous Noninvasive Orthostatic Blood Pressure Measurements and Their Relationship with Orthostatic Intolerance, Falls, and Frailty in Older People , 2011, Journal of the American Geriatrics Society.

[3]  Marten Scheffer,et al.  Complex systems: Foreseeing tipping points , 2010, Nature.

[4]  D. V. von Cramon,et al.  The Effect of Esmolol on Cerebral Blood Flow, Cerebral Vasoreactivity, and Cognitive Performance: A Functional Magnetic Resonance Imaging Study , 2005, Anesthesiology.

[5]  Hirofumi Tanaka,et al.  Regular aerobic exercise modulates age‐associated declines in cardiovagal baroreflex sensitivity in healthy men , 2000, The Journal of physiology.

[6]  R. Havlik,et al.  Midlife blood pressure and dementia: the Honolulu–Asia aging study☆ , 2000, Neurobiology of Aging.

[7]  Harlan M Krumholz,et al.  Representation of the elderly, women, and minorities in heart failure clinical trials. , 2002, Archives of internal medicine.

[8]  J A H R Claassen,et al.  Reproducibility of cerebral blood volume measurements by near infrared spectroscopy in 16 healthy elderly subjects , 2006, Physiological measurement.

[9]  Luigi Ferrucci,et al.  Association Between Reduced Heart Rate Variability and Cognitive Impairment in Older Disabled Women in the Community: Women's Health and Aging Study I , 2006, Journal of the American Geriatrics Society.

[10]  N. Secher,et al.  Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes. , 2008, Clinical science.

[11]  M. Brignole,et al.  Long-term outcome in symptomatic carotid sinus hypersensitivity. , 1992, American heart journal.

[12]  Joep Lagro,et al.  Impaired cerebral autoregulation and vasomotor reactivity in sporadic Alzheimer's disease. , 2014, Current Alzheimer research.

[13]  A. J. Dunning,et al.  Mechanisms of initial heart rate response to postural change. , 1982, The American journal of physiology.

[14]  O. Paulson,et al.  No effect of angiotensin II AT2-receptor antagonist PD 123319 on cerebral blood flow autoregulation , 2001, Journal of the renin-angiotensin-aldosterone system : JRAAS.

[15]  Eri Shijaku,et al.  Dynamic cerebral autoregulation in subjects with Alzheimer's disease, mild cognitive impairment, and controls: evidence for increased peripheral vascular resistance with possible predictive value. , 2012, Journal of Alzheimer's disease : JAD.

[16]  M. Scheffer,et al.  Global Resilience of Tropical Forest and Savanna to Critical Transitions , 2011, Science.

[17]  Rong Zhang,et al.  Altered cerebral hemodynamics in early Alzheimer disease: a pilot study using transcranial Doppler. , 2009, Journal of Alzheimer's disease : JAD.

[18]  Daan L. K. de Jong,et al.  Geriatric hypotensive syndromes are not explained by cardiovascular autonomic dysfunction alone , 2012 .

[19]  R. Zulli,et al.  QT Dispersion and Heart Rate Variability Abnormalities in Alzheimer's Disease and in Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[20]  J. Jankovic,et al.  Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy , 2005, Clinical Autonomic Research.

[21]  D. Holtzman,et al.  Clearance of amyloid beta-peptide from brain: transport or metabolism? , 2000, Nature medicine.

[22]  D. Levy,et al.  Incidence and prognosis of syncope. , 2002, The New England journal of medicine.

[23]  R. Jansen,et al.  The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  B. J. Sjöberg,et al.  Cardiac output and blood pressure during active and passive standing. , 1996, Clinical physiology.

[25]  Rune Aaslid,et al.  Comparison of Flow and Velocity During Dynamic Autoregulation Testing in Humans , 1994, Stroke.

[26]  Y. Schoon,et al.  Hypotensive Syndromes Are Not Associated With Cognitive Impairment in Geriatric Patients , 2013, American journal of Alzheimer's disease and other dementias.

[27]  Aisha S S Meel-van den Abeelen,et al.  Impaired systolic blood pressure recovery directly after standing predicts mortality in older falls clinic patients. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[28]  Marten Scheffer,et al.  Slow Recovery from Perturbations as a Generic Indicator of a Nearby Catastrophic Shift , 2007, The American Naturalist.

[29]  A. Murray,et al.  Autonomic dysfunction in dementia , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[30]  J. Kellett.  Prognostication--the lost skill of medicine. , 2008, European journal of internal medicine.

[31]  Rong Zhang,et al.  Dynamic pressure–flow relationship of the cerebral circulation during acute increase in arterial pressure , 2009, The Journal of physiology.

[32]  B. Imholz,et al.  Orthostatic circulatory control in the elderly evaluated by non-invasive continuous blood pressure measurement. , 1990, Clinical science.

[33]  W. Wieling,et al.  Differences in circulatory control in normal subjects who faint and who do not faint during orthostatic stress , 1993, Clinical Autonomic Research.

[34]  S. Oppenheimer,et al.  Insular cortex lesions alter baroreceptor sensitivity in the urethane-anesthetized rat , 1998, Brain Research.

[35]  L. Pezawas,et al.  Receptor Test (Pupillary Dilatation after Application of 0.01% Tropicamide Solution) and Determination of Central Nervous Activation (Fourier Analysis of Pupillary Oscillations) in Patients with Alzheimer’s Disease , 1999, Neuropsychobiology.

[36]  W. Maughan,et al.  Finger photoplethysmography during the Valsalva maneuver reflects left ventricular filling pressure. , 2012, American journal of physiology. Heart and circulatory physiology.

[37]  H. Braak,et al.  Evolution of neuronal changes in the course of Alzheimer's disease. , 1998, Journal of neural transmission. Supplementum.

[38]  O. Dekkers,et al.  Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis. , 2010, The Journal of clinical endocrinology and metabolism.

[39]  Don L. Armstrong,et al.  Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease , 2005, Nature Medicine.

[40]  R. Melis,et al.  Importance of comorbidity in competing risks analysis in patients with localized renal cell carcinoma. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  J. Bigger,et al.  Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction , 1998, The Lancet.

[42]  J. Claassen,et al.  HOW SHOULD WE MEASURE RENAL FUNCTION IN OLDER HOSPITAL PATIENTS? , 2010, Journal of the American Geriatrics Society.

[43]  J. Hartikainen,et al.  Effect of posture on baroreflex sensitivity in healthy subjects. , 1995, Clinical physiology.

[44]  P. Bories,et al.  Impact of comorbidities on hospital-acquired infections in a geriatric rehabilitation unit: prospective study of 252 patients. , 2012, Journal of the American Medical Directors Association.

[45]  B. Levine,et al.  Carotid sinus “irritability” rather than hypersensitivity: a new name for an old syndrome? , 2001, Clinical Autonomic Research.

[46]  P. Scheltens,et al.  Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[47]  Lei Dai,et al.  Generic Indicators for Loss of Resilience Before a Tipping Point Leading to Population Collapse , 2012, Science.

[48]  Alistair Burns,et al.  The burden of Alzheimer's disease. , 2000, The international journal of neuropsychopharmacology.

[49]  M. Blaufox,et al.  The association of postural changes in systolic blood pressure and mortality in persons with hypertension: the Hypertension Detection and Follow-up Program experience. , 1987, Circulation.

[50]  P. Luiten,et al.  Cerebral microvascular pathology in aging and Alzheimer's disease , 2001, Progress in Neurobiology.

[51]  Pietro Cortelli,et al.  Guidelines for the diagnosis and management of syncope (version 2009). , 2009, European heart journal.

[52]  Daniel W. Jones,et al.  Orthostatic Hypotension as a Risk Factor for Stroke: The Atherosclerosis Risk in Communities (ARIC) Study, 1987–1996 , 2000, Stroke.

[53]  K. Wesseling,et al.  Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. , 1998, Cardiovascular research.

[54]  T. Ogihara,et al.  Mechanisms mediating postprandial blood pressure reduction in young and elderly subjects. , 1996, American journal of hypertension.

[55]  G. Rasi,et al.  Drug policy for an aging population--the European Medicines Agency's geriatric medicines strategy. , 2012, The New England journal of medicine.

[56]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease , 2011, Neurology.

[57]  E. Shimosegawa,et al.  Hemodynamic Aspects of Alzheimer's Disease , 2002, Annals of the New York Academy of Sciences.

[58]  J. Coyle,et al.  Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis , 1981, Annals of neurology.

[59]  M. O. Olde Rikkert,et al.  Early postural blood pressure response and cause-specific mortality among middle-aged adults: what is the role of diastolic blood pressure? , 2011, European Journal of Epidemiology.

[60]  A. Michell.  Prognostic significance of blood-pressure variability , 2010, The Lancet.

[61]  L. Lipsitz.  Dynamics of stability: the physiologic basis of functional health and frailty. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[62]  F. Giubilei,et al.  Cardiac Autonomic Dysfunction in Patients with Alzheimer Disease: Possible Pathogenetic Mechanisms , 1998, Alzheimer disease and associated disorders.

[63]  R. Dampney,et al.  Functional Organization of Brain Pathways Subserving the Baroreceptor Reflex: Studies in Conscious Animals Using Immediate Early Gene Expression , 2003, Cellular and Molecular Neurobiology.

[64]  M. Horowitz,et al.  The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects , 2008, Clinical Autonomic Research.

[65]  Stephanie Studenski,et al.  Geriatric Syndromes: Clinical, Research, and Policy Implications of a Core Geriatric Concept , 2007, Journal of the American Geriatrics Society.

[66]  A. Murray,et al.  Results of carotid sinus massage in a tertiary referral unit--is carotid sinus syndrome still relevant? , 2009, Age and ageing.

[67]  A. Pedotti,et al.  Evaluation of the Baroreceptor‐Heart Rate Reflex by 24‐Hour Intra‐arterial Blood Pressure Monitoring in Humans , 1988, Hypertension.

[68]  P. Low,et al.  Prevalence of orthostatic hypotension , 2008, Clinical Autonomic Research.

[69]  Constantine Lyketsos,et al.  Dementia and Alzheimer's Disease Incidence in Relationship to Cardiovascular Disease in the Cardiovascular Health Study Cohort , 2005, Journal of the American Geriatrics Society.

[70]  J. Claassen,et al.  Letter by Lagro et al regarding article, "Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing guided by adenosine 5'-triphosphate testing". , 2012, Circulation.

[71]  P. Scheltens,et al.  Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. , 2009, Archives of general psychiatry.

[72]  David M Holtzman,et al.  Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-β Peptide, Partial Restoration via γ-Secretase Inhibition , 2008, The Journal of Neuroscience.

[73]  Andrew Brooks,et al.  Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype , 2007, Proceedings of the National Academy of Sciences.

[74]  Rong Zhang,et al.  Dynamic cerebral autoregulation during repeated squat-stand maneuvers. , 2009, Journal of applied physiology.

[75]  O. Melander,et al.  Consequences of orthostatic blood pressure variability in middle-aged men (The Malmö Preventive Project) , 2010, Journal of hypertension.

[76]  Gian Domenico Pinna,et al.  Baroreflex Sensitivity: Measurement and Clinical Implications , 2008, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[77]  Albert Hofman,et al.  Orthostatic Hypotension and Risk of Cardiovascular Disease in Elderly People: The Rotterdam Study , 2008, Journal of the American Geriatrics Society.

[78]  Eduardo Gil,et al.  Dynamic assessment of spontaneous baroreflex sensitivity by means of time-frequency analysis using either RR or pulse interval variability , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[79]  Charles E McCulloch,et al.  Relaxing the rule of ten events per variable in logistic and Cox regression. , 2007, American journal of epidemiology.

[80]  D. Forman,et al.  Representation of older adults in the late-breaking clinical trials American Heart Association 2011 Scientific Sessions. , 2012, Journal of the American College of Cardiology.

[81]  János Kálmán,et al.  Depressed baroreflex sensitivity in patients with Alzheimer’s and Parkinson’s disease , 2001, Neurobiology of Aging.

[82]  A. Weiss,et al.  Validity of the Medication-Based Disease Burden Index Compared with the Charlson Comorbidity Index and the Cumulative Illness Rating Scale for Geriatrics , 2011, Drugs & aging.

[83]  O. Hanon,et al.  Relationship between orthostatic hypotension and cognitive impairment in the elderly , 2010, Journal of the Neurological Sciences.

[84]  M. O. Olde Rikkert,et al.  Geriatric syndromes: medical misnomer or progress in geriatrics? , 2003, The Netherlands journal of medicine.

[85]  Jeffrey M. Hausdorff,et al.  When human walking becomes random walking: fractal analysis and modeling of gait rhythm fluctuations. , 2001, Physica A.

[86]  L. Lipsitz,et al.  Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension. , 2000, Stroke.

[87]  A L Goldberger,et al.  Effects of central muscarinic-1 receptor stimulation on blood pressure regulation. , 1997, Hypertension.

[88]  M. Scheffer,et al.  Slowing down as an early warning signal for abrupt climate change , 2008, Proceedings of the National Academy of Sciences.

[89]  G. Parati,et al.  How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life , 2000, Journal of hypertension.

[90]  S. Carpenter,et al.  Methods for Detecting Early Warnings of Critical Transitions in Time Series Illustrated Using Simulated Ecological Data , 2012, PloS one.

[91]  Rose Anne Kenny,et al.  Guidelines on management (diagnosis and treatment) of syncope--update 2004. , 2004, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[92]  A. Mitnitski,et al.  Limits to deficit accumulation in elderly people , 2006, Mechanisms of Ageing and Development.

[93]  A. Ehlis,et al.  Non-invasive measurement of vagus activity in the brainstem – a methodological progress towards earlier diagnosis of dementias? , 2007, Journal of Neural Transmission.

[94]  P. Visser,et al.  Predictive Accuracy of MCI Subtypes for Alzheimer’s Disease and Vascular Dementia in Subjects with Mild Cognitive Impairment: A 2-Year Follow-Up Study , 2005, Dementia and Geriatric Cognitive Disorders.

[95]  L. Lipsitz.  What's Different About Syncope in the Aged? , 1993, The American journal of geriatric cardiology.

[96]  J. V. van Lieshout,et al.  Circulatory response evoked by a 3 s bout of dynamic leg exercise in humans. , 1996, The Journal of physiology.

[97]  Jenny Dankelman,et al.  Relation between branching patterns and perfusion in stochastic generated coronary arterial trees , 2007, Medical & Biological Engineering & Computing.

[98]  Karen J. Buth,et al.  Frail Patients Are at Increased Risk for Mortality and Prolonged Institutional Care After Cardiac Surgery , 2010, Circulation.

[99]  A. Mitnitski,et al.  A comparison of two approaches to measuring frailty in elderly people. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[100]  A. Korczyn.  The amyloid cascade hypothesis , 2008, Alzheimer's & Dementia.

[101]  K H Wesseling,et al.  Initial blood pressure fall on stand up and exercise explained by changes in total peripheral resistance. , 1991, Journal of applied physiology.

[102]  V. Somers,et al.  Arterial baroreflex function and cardiovascular variability: interactions and implications. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[103]  D. Foley,et al.  Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. , 1998, Circulation.

[104]  Maw Pin Tan,et al.  The relationship between carotid sinus hypersensitivity, orthostatic hypotension, and vasovagal syncope: a case-control study. , 2008, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[105]  Sati Mazumdar,et al.  Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale , 1992, Psychiatry Research.

[106]  W. Srikusalanukul,et al.  Postprandial Hypotension Predicts All‐Cause Mortality in Older, Low‐Level Care Residents , 2005, Journal of the American Geriatrics Society.

[107]  A L Goldberger,et al.  On a mechanism of cardiac electrical stability. The fractal hypothesis. , 1985, Biophysical journal.

[108]  D. Bild,et al.  Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. , 1992, Hypertension.

[109]  R. Jansen,et al.  High prevalence of postprandial and orthostatic hypotension among geriatric patients admitted to Dutch hospitals. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[110]  Martin Mueller,et al.  Linearity and non-linearity in cerebral hemodynamics. , 2003, Medical engineering & physics.

[111]  F. Puisieux,et al.  Ambulatory blood pressure monitoring and postprandial hypotension in elderly persons with falls or syncopes. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[112]  A. J. Dunning,et al.  Mechanisms of initial blood pressure response to postural change. , 1984, Clinical science.

[113]  B. Rosen,et al.  Evidence of a Cerebrovascular Postarteriole Windkessel with Delayed Compliance , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[114]  Godfrey Pearlson,et al.  Average Daily Blood Pressure, Not Office Blood Pressure, Is Associated With Progression of Cerebrovascular Disease and Cognitive Decline in Older People , 2011, Circulation.

[115]  S. Studenski,et al.  Gait speed and survival in older adults. , 2011, JAMA.

[116]  Z. Wszolek,et al.  VASCULAR RISK FACTORS AND DEMENTIA: HOW TO MOVE FORWARD? , 2009, Neurology.

[117]  Karel H Wesseling,et al.  Validation of brachial artery pressure reconstruction from finger arterial pressure , 2008, Journal of hypertension.

[118]  J. Claassen,et al.  Letter by Lagro et al regarding article, "average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people". , 2012, Circulation.

[119]  H. Robbe,et al.  Assessment of baroreceptor reflex sensitivity by means of spectral analysis. , 1987, Hypertension.

[120]  R. Kenny,et al.  Mayer wave activity in vasodepressor carotid sinus hypersensitivity. , 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[121]  B. Levine,et al.  Transfer function analysis of dynamic cerebral autoregulation in humans. , 1998, American journal of physiology. Heart and circulatory physiology.

[122]  B. Lernfelt,et al.  15-year longitudinal study of blood pressure and dementia , 1996, The Lancet.

[123]  S. Studenski,et al.  Predicting chemotherapy toxicity in older adults and the importance of geriatric assessment. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[124]  L. Lipsitz,et al.  Orthostatic hypotension in the elderly: diagnosis and treatment. , 2007, The American journal of medicine.

[125]  L. Lipsitz,et al.  Spectral indices of human cerebral blood flow control: responses to augmented blood pressure oscillations , 2004, The Journal of physiology.

[126]  L. Amaral,et al.  Multifractality in human heartbeat dynamics , 1998, Nature.

[127]  G. Parati,et al.  Modification of arterial baroreflexes by captopril in essential hypertension. , 1982, The American journal of cardiology.

[128]  Lewis A. Lipsitz,et al.  Dynamic models for the study of frailty , 2008, Mechanisms of Ageing and Development.

[129]  G C Roman,et al.  Brain infarction and the clinical expression of Alzheimer disease. , 1997, JAMA.

[130]  R. Kornowski,et al.  Influence of orthostatic hypotension on mortality among patients discharged from an acute geriatric ward , 2006, Journal of General Internal Medicine.

[131]  I. Räihä,et al.  Prevalence, predisposing factors, and prognostic importance of postural hypotension. , 1995, Archives of internal medicine.

[132]  L Faes,et al.  Causal linear parametric model for baroreflex gain assessment in patients with recent myocardial infarction. , 2001, American journal of physiology. Heart and circulatory physiology.

[133]  B. Lawlor,et al.  Parasympathetic autonomic dysfunction is common in mild cognitive impairment , 2012, Neurobiology of Aging.

[134]  S. Gates,et al.  Multifactorial assessment and targeted intervention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis , 2007, BMJ : British Medical Journal.

[135]  G. Mairesse,et al.  Treatment of Unexplained Syncope: A Multicenter, Randomized Trial of Cardiac Pacing Guided by Adenosine 5′-Triphosphate Testing , 2012, Circulation.

[136]  P. Scheltens,et al.  A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT , 2001, Stroke.

[137]  M. O. Olde Rikkert,et al.  Dynamic cerebral autoregulation in the old using a repeated sit-stand maneuver. , 2010, Ultrasound in medicine & biology.

[138]  Albert Hofman,et al.  Arterial stiffness, cardiovagal baroreflex sensitivity and postural blood pressure changes in older adults: The Rotterdam Study , 2007, Journal of hypertension.

[139]  Peter J. F. Lucas,et al.  Multilevel Bayesian networks for the analysis of hierarchical health care data , 2013, Artif. Intell. Medicine.

[140]  R A Kenny,et al.  The Newcastle protocols for head-up tilt table testing in the diagnosis of vasovagal syncope, carotid sinus hypersensitivity, and related disorders , 2000, Heart.

[141]  A. J. Honour,et al.  Diminished Baroreflex Sensitivity in High Blood Pressure , 1969, Circulation.

[142]  Ronald A Cohen,et al.  Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease , 2005, Blood pressure.

[143]  S. Carpenter,et al.  Early-warning signals for critical transitions , 2009, Nature.

[144]  M. Friger,et al.  The effect of co-morbidity on the rehabilitation process in elderly patients after hip fracture. , 2007, Archives of gerontology and geriatrics.

[145]  Cornelius Weiller,et al.  Oscillatory cerebral hemodynamics—the macro- vs. microvascular level , 2006, Journal of the Neurological Sciences.

[146]  R. Hainsworth,et al.  Spectral and cross-spectral autoregressive analysis of cardiovascular variables in subjects with different degrees of orthostatic tolerance , 2001, Clinical Autonomic Research.

[147]  K. Takazawa,et al.  Hemodynamic changes in Alzheimer's and Binswanger's diseases as evaluated by second‐derivative finger photoplethysmography , 2003 .

[148]  A. Goldberger,et al.  Hemodynamic and Autonomic Nervous System Responses to Mixed Meal Ingestion in Healthy Young and Old Subjects and Dysautonomic Patients With Postprandial Hypotension , 1993, Circulation.

[149]  Karel H Wesseling,et al.  Finometer, finger pressure measurements with the possibility to reconstruct brachial pressure , 2003, Blood pressure monitoring.

[150]  H V Huikuri,et al.  Prediction of sudden cardiac death by fractal analysis of heart rate variability in elderly subjects. , 2001, Journal of the American College of Cardiology.

[151]  R. Fagard,et al.  Orthostatic Hypotension Is a More Robust Predictor of Cardiovascular Events Than Nighttime Reverse Dipping in Elderly , 2010, Hypertension.

[152]  Albert,et al.  Emergence of scaling in random networks , 1999, Science.

[153]  M. Trabucchi,et al.  PREDICTORS OF PROGRESSION FROM MILD COGNITIVE IMPAIRMENT TO ALZHEIMER DISEASE , 2008, Neurology.

[154]  R. Weidgraaf,et al.  Bloedtransfusies bij oudere patiënten: pas het beleid aan bij kwetsbaarheid! , 2010 .

[155]  O. Melander,et al.  Early postural blood pressure response and cause-specific mortality among middle-aged adults , 2011, European Journal of Epidemiology.

[156]  Bruce J. West,et al.  Fractal fluctuations in cardiac time series. , 1999, Physica A.

[157]  M. Siddiqui,et al.  Assessment of cardiovascular autonomic function. , 1995, Journal of the American College of Cardiology.

[158]  V. Moyer.  Prevention of Falls in Community-Dwelling Older Adults: U.S. Preventive Services Task Force Recommendation Statement , 2012, Annals of Internal Medicine.

[159]  D. Lyons,et al.  Postprandial hypotension. , 2002, Clinics in geriatric medicine.

[160]  W. Wieling,et al.  Initial circulatory responses to changes in posture: influence of the angle and speed of tilt. , 1991, Clinical physiology.

[161]  J. Claassen,et al.  Cerebral hemodynamics after short and long‐term reduction in blood pressure in mild and moderate hypertension , 2007, Hypertension.

[162]  J. Fleg,et al.  Frequency and importance of postprandial blood pressure reduction in elderly nursing-home patients. , 1991, Annals of internal medicine.

[163]  Dag Aarsland,et al.  Role of Cholinesterase Inhibitors in Parkinson’s Disease and dementia with Lewy Bodies , 2004, Journal of geriatric psychiatry and neurology.

[164]  M. Extermann,et al.  Measuring comorbidity in older cancer patients. , 2000, European journal of cancer.

[165]  Mark Linzer,et al.  Initial orthostatic hypotension: review of a forgotten condition. , 2007, Clinical science.

[166]  S. Studenski,et al.  Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults , 2006, Journal of the American Geriatrics Society.

[167]  Jeffrey M. Hausdorff,et al.  Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington's disease. , 1997, Journal of applied physiology.

[168]  L. Ferrucci,et al.  Trajectories of gait speed predict mortality in well-functioning older adults: the Health, Aging and Body Composition study. , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

[169]  J. Claassen,et al.  Cerebral Autoregulation: An Overview of Current Concepts and Methodology with Special Focus on the Elderly , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[170]  Stability of the noninvasive baroreflex sensitivity assessment using cross‐spectral analysis of heart rate and arterial blood pressure variabilities , 2000, Clinical cardiology.

[171]  L. Faes,et al.  Spectral decomposition of RR-variability obtained by an open loop parametric model for the diagnosis of neuromediate syncope , 2001, Computers in Cardiology 2001. Vol.28 (Cat. No.01CH37287).

[172]  Diastolic blood pressure drop after standing as a clinical sign for increased mortality in older falls clinic patients , 2012 .

[173]  H. M. Kuipers,et al.  The Influence of Food Temperature on Postprandial Blood Pressure Reduction and Its Relation to Substance‐P in Healthy Elderly Subjects , 1991, Journal of the American Geriatrics Society.

[174]  C. Giller,et al.  Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. , 1993, Neurosurgery.

[175]  D. Ziegler,et al.  A simple deep breathing test reveals altered cerebral autoregulation in type 2 diabetic patients , 2008, Diabetologia.

[176]  M. Kikuya,et al.  Prognostic Significance of Blood Pressure and Heart Rate Variabilities: The Ohasama Study , 2000, Hypertension.

[177]  Kazuo Abe,et al.  Total daily physical activity and the risk of AD and cognitive decline in older adults , 2012, Neurology.

[178]  N. Pandita-Gunawardena,et al.  Amlodipine lowers blood pressure without affecting cerebral blood flow as measured by single photon emission computed tomography in elderly hypertensive subjects. , 1999, Age and ageing.

[179]  M. Scheffer,et al.  Robustness of variance and autocorrelation as indicators of critical slowing down. , 2012, Ecology.

[180]  A. Sharrett,et al.  Orthostatic Hypotension Predicts Mortality in Middle-Aged Adults: The Atherosclerosis Risk in Communities (ARIC) Study , 2006, Circulation.

[181]  P. Laippala,et al.  Prognosis of diastolic and systolic orthostatic hypotension in older persons. , 1999, Archives of internal medicine.

[182]  Claude Gharib,et al.  Spontaneous baroreflex sensitivity: toward an ideal index of cardiovascular risk in hypertension? , 2002, Journal of hypertension.

[183]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[184]  E. Perry,et al.  A cholinergic connection between normal aging and senile dementia in the human hippocampus , 1977, Neuroscience Letters.

[185]  B K Rutt,et al.  MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. , 2000, Stroke.

[186]  R. Quaife,et al.  Altered Autonomic Support of Arterial Blood Pressure With Age in Healthy Men , 2001, Circulation.

[187]  A. Villringer,et al.  Spontaneous Low Frequency Oscillations of Cerebral Hemodynamics and Metabolism in Human Adults , 2000, NeuroImage.

[188]  J. Claassen,et al.  Short review: Acetylcholinesterase-inhibitors in Alzheimer’s disease have opposing effects on blood pressure and cerebral perfusion , 2009 .

[189]  J. Potter,et al.  Orthostatic blood pressure changes and arterial baroreflex sensitivity in elderly subjects. , 1999, Age and ageing.

[190]  C. Iadecola,et al.  Threats to the Mind: Aging, Amyloid, and Hypertension , 2009, Stroke.

[191]  R. Varadhan,et al.  Opinion section on frailty , 2008, Mechanisms of Ageing and Development.

[192]  R. Aaslid,et al.  Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. , 1982, Journal of neurosurgery.

[193]  Maw Pin Tan,et al.  Carotid sinus hypersensitivity: disease state or clinical sign of ageing? Insights from a controlled study of autonomic function in symptomatic and asymptomatic subjects. , 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[194]  Sathya Karunananthan,et al.  Role of frailty in patients with cardiovascular disease. , 2009, The American journal of cardiology.

[195]  O. Melander,et al.  Syndromes of orthostatic intolerance: a hidden danger , 2013, Journal of internal medicine.

[196]  Rong Zhang,et al.  Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease , 2012, Neurobiology of Aging.

[197]  Jeffrey M. Hausdorff,et al.  Quantifying Fractal Dynamics of Human Respiration: Age and Gender Effects , 2002, Annals of Biomedical Engineering.

[198]  T. Gill,et al.  A standard procedure for creating a frailty index , 2008, BMC geriatrics.

[199]  Y. Schoon,et al.  Comparison of different strategies of referral to a fall clinic: How to achieve an optimal casemix? , 2010, The journal of nutrition, health & aging.

[200]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[201]  A. Weiss,et al.  Orthostatic hypotension in acute geriatric ward: is it a consistent finding? , 2002, Archives of internal medicine.

[202]  D. Wilkie.  A Series of Signed Articles contributed by invitation , 1934 .

[203]  F. Verhey,et al.  The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia. , 2010, Current Alzheimer research.

[204]  M. Hilz,et al.  Cardiovascular and cerebrovascular responses to lower body negative pressure in type 2 diabetic patients , 2007, Journal of the Neurological Sciences.

[205]  C. Mussi,et al.  Orthostatic hypotension as cause of syncope in patients older than 65 years admitted to emergency departments for transient loss of consciousness. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[206]  V. Jaddoe,et al.  Letter by Lagro et al regarding article, "Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease". , 2011, Circulation.

[207]  T. Erkinjuntti,et al.  Postural Hypotension and Dizziness in a General Aged Population: A Four‐Year Follow‐Up of the Helsinki Aging Study , 1996, Journal of the American Geriatrics Society.

[208]  L. Lipsitz.  Age-related changes in the "complexity" of cardiovascular dynamics: A potential marker of vulnerability to disease. , 1995, Chaos.

[209]  T. Saleh,et al.  Role of the insular cortex in the modulation of baroreflex sensitivity. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[210]  A. Hofman,et al.  Antihypertensive drugs and incidence of dementia: the Rotterdam Study , 2001, Neurobiology of Aging.

[211]  P. Laippala,et al.  Orthostatic hypotension and the risk of myocardial infarction in the home‐dwelling elderly , 2004, Journal of internal medicine.

[212]  H. Maas,et al.  Predictors of early death risk in older patients treated with first-line chemotherapy for cancer and the importance of geriatric assessment. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[213]  R. Page,et al.  Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. , 1996, The American journal of cardiology.

[214]  B. Platt,et al.  Involvement of the cholinergic system in conditioning and perceptual memory , 2011, Behavioural Brain Research.

[215]  J. Claassen,et al.  Baroreflex function is reduced in Alzheimer’s disease: a candidate biomarker? , 2013, Neurobiology of Aging.

[216]  S. Campbell,et al.  A systematic literature review of factors affecting outcome in older medical patients admitted to hospital. , 2004, Age and ageing.

[217]  A. Sharrett,et al.  Orthostatic hypotension and the incidence of coronary heart disease: the Atherosclerosis Risk in Communities study. , 2000, American journal of hypertension.

[218]  C. Morillo,et al.  Diagnostic utility of mechanical, pharmacological and orthostatic stimulation of the carotid sinus in patients with unexplained syncope. , 1996, Journal of the American College of Cardiology.

[219]  Rose Anne Kenny,et al.  Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. , 2006, Archives of internal medicine.

[220]  J. Andrew Taylor,et al.  Age-related effects of vagotonic atropine on cardiovagal baroreflex gain , 2012, Neurobiology of Aging.

[221]  L. Lipsitz,et al.  Intra-individual postural blood pressure variability and stroke in elderly nursing home residents. , 2001, Journal of clinical epidemiology.

[222]  W. Markesbery,et al.  Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants , 2002, Annals of the New York Academy of Sciences.

[223]  W. Aronow,et al.  Association of Postprandial Hypotension With Incidence of Falls, Syncope, Coronary Events, Stroke, and Total Mortality at 29‐Month Follow‐Up in 499 Older Nursing Home Residents , 1997, Journal of the American Geriatrics Society.

[224]  G. Langewouters,et al.  Continuous finger arterial pressure: Utility in the cardiovascular laboratory , 1991, Clinical Autonomic Research.

[225]  S. Carpenter,et al.  Early Warnings of Regime Shifts: A Whole-Ecosystem Experiment , 2011, Science.

[226]  L. Tarassenko,et al.  Synchronization between arterial blood pressure and cerebral oxyhaemoglobin concentration investigated by wavelet cross-correlation , 2007, Physiological measurement.

[227]  P. Low,et al.  Management of neurogenic orthostatic hypotension: an update , 2008, The Lancet Neurology.

[228]  E. O’Brien,et al.  Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension , 2010, The Lancet.

[229]  Manuel Varela,et al.  Temperature curve complexity predicts survival in critically ill patients. , 2006, American journal of respiratory and critical care medicine.

[230]  K. Scher,et al.  Under-representation of older adults in cancer registration trials: known problem, little progress. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[231]  M. Sykora,et al.  Modulation of Baroreceptor Reflex Sensitivity May Represent a New Therapeutic Target in Acute Stroke , 2009 .

[232]  O. Melander,et al.  Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmö Preventive Project) , 2009, European heart journal.

[233]  D. V. von Cramon,et al.  Spontaneous Low-Frequency Oscillations Decline in the Aging Brain , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.