Prevalence of vaccine‐induced escape mutants of hepatitis B virus in the adult population in China: A prospective study in 176 restaurant employees

Background and Aim: Hepatitis B virus (HBV) variants with mutations in the S gene would pose a substantial risk to the community as current HBV vaccines are not effective in preventing infection with them. The majority of such vaccine escape mutants so far reported have been found while studying vertical transmission of HBV; the vaccine failure rate in connection with vaccine escape mutants in adults is not clear at the moment. The purpose of this study was to evaluate the efficacy of immunization against HBV in the adult population by analysis using polymerase chain reaction (PCR) to detect HBV‐DNA, and also to elucidate the type of mutation encountered in vaccine failure cases.

[1]  Wei Ning Chen,et al.  Detection of hepatitis B surface antigen mutants and their integration in human hepatocellular carcinoma. , 1999 .

[2]  A. Theamboonlers,et al.  Molecular analysis of the a determinant of HBsAg in children of HBeAg-positive mothers upon failure of postexposure prophylaxis. , 1998, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[3]  H. Hsu,et al.  Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis , 1997, Hepatology.

[4]  R. Purcell,et al.  Infectivity and pathogenicity in chimpanzees of a surface gene mutant of hepatitis B virus that emerged in a vaccinated infant. , 1997, The Journal of infectious diseases.

[5]  S. Mishiro,et al.  Therapeutic effect of preS2-containing vaccine in an infant infected with a vaccine-escape variant (Thr) of hepatitis B virus , 1997 .

[6]  G. Yao,et al.  Importance of perinatal versus horizontal transmission of hepatitis B virus infection in China. , 1996, Gut.

[7]  J. Yao,et al.  Perinatal transmission of hepatitis B virus infection and vaccination in China. , 1996, Gut.

[8]  L. Mimms,et al.  Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA , 1995, The Lancet.

[9]  Z. Ye,et al.  Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. , 1995, Vaccine.

[10]  H. Okamoto,et al.  Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen , 1994, Journal of virology.

[11]  I. Mushahwar,et al.  Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. , 1993, The Journal of general virology.

[12]  A. Widell,et al.  Hepatitis B virus DNA in serum and liver is commonly found in chinese patients with chronic liver disease despite the presence of antibodies to HBsAg , 1993, Hepatology.

[13]  M. Hou,et al.  Heterosexual transmission as the most common route of acute hepatitis B virus infection among adults in Taiwan--the importance of extending vaccination to susceptible adults. , 1993, The Journal of infectious diseases.

[14]  A. Mason,et al.  Serum and liver hepatitis B virus DNA in chronic hepatitis B after sustained loss of surface antigen. , 1992, Gastroenterology.

[15]  H. Miyazaki,et al.  Mutations within the S Gene of Hepatitis B Virus Transmitted from Mothers to Babies Immunized with Hepatitis B Immune Globulin and Vaccine , 1992, Pediatric Research.

[16]  Y. Sakaki,et al.  Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus. , 1992, Biochemical and biophysical research communications.

[17]  Linda A Mccarthy,et al.  Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody—treated liver transplant patients , 1992, Hepatology.

[18]  A. Zuckerman,et al.  Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. , 1991, Journal of hepatology.

[19]  A. Zuckerman,et al.  Vaccine-induced escape mutant of hepatitis B virus , 1990, The Lancet.

[20]  F Tsuda,et al.  Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen , 1990, Journal of virology.

[21]  H. Okamoto,et al.  Hepatitis B surface antigen particles with all four subtypic determinants: point mutations of hepatitis B virus DNA inducing phenotypic changes or double infection with viruses of different subtypes. , 1990, Molecular immunology.

[22]  S. Mishiro,et al.  A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A M Prince,et al.  Antibodies to a synthetic peptide from the preS 120-145 region of the hepatitis B virus envelope are virus neutralizing. , 1986, Vaccine.

[24]  F. Chisari,et al.  Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[25]  F. Chisari,et al.  Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen. , 1985, Science.

[26]  Y. Ono,et al.  Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw , 1983 .