Stochastic effects and bistability in T cell receptor signaling.

[1]  Zhengyu Ma,et al.  Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity , 2008, PLoS biology.

[2]  Daniel Coombs,et al.  Kinetic proofreading model. , 2008, Advances in experimental medicine and biology.

[3]  A. Sigalov.  Multichain immune recognition receptor signaling from spatiotemporal organization to human disease. Preface. , 2008, Advances in experimental medicine and biology.

[4]  Jayajit Das,et al.  Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities , 2007, Proceedings of the National Academy of Sciences.

[5]  Marek Kimmel,et al.  Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling , 2007, BMC Bioinformatics.

[6]  P. A. van der Merwe,et al.  Molecular mechanisms involved in T cell receptor triggering. , 2007, Seminars in immunology.

[7]  Mark M Davis,et al.  A role for "self" in T-cell activation. , 2007, Seminars in immunology.

[8]  N. Burroughs,et al.  Stochasticity and spatial heterogeneity in T‐cell activation , 2007, Immunological reviews.

[9]  Jayajit Das,et al.  Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module , 2007, Proceedings of the National Academy of Sciences.

[10]  Nigel J Burroughs,et al.  Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation. , 2006, Biophysical journal.

[11]  N. Burroughs,et al.  T-cell activation: A queuing theory analysis at low agonist density. , 2006, Biophysical journal.

[12]  Mark M. Davis,et al.  Deconstructing the form and function of the TCR/CD3 complex. , 2006, Immunity.

[13]  Jin Yang,et al.  Graph Theory for Rule-Based Modeling of Biochemical Networks , 2006, Trans. Comp. Sys. Biology.

[14]  J. Stark,et al.  Understanding specificity and sensitivity of T-cell recognition. , 2005, Trends in immunology.

[15]  Marietta L. Harrison,et al.  Modeling and analysis of early events in T-lymphocyte antigen-activated intracellular-signaling pathways , 2005 .

[16]  M. Amarzguioui,et al.  Short-Interfering RNA-Mediated Lck Knockdown Results in Augmented Downstream T Cell Responses1 , 2005, The Journal of Immunology.

[17]  Ronald N Germain,et al.  Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses , 2005, PLoS biology.

[18]  Andrea Omicini,et al.  Proceedings of the 2005 ACM Symposium on Applied Computing (SAC), Santa Fe, New Mexico, USA, March 13-17, 2005 , 2005, SAC.

[19]  William S. Hlavacek,et al.  Graphical rule-based representation of signal-transduction networks , 2005, SAC '05.

[20]  William S. Hlavacek,et al.  Rule-based modeling of biochemical networks , 2005, Complex..

[21]  William S. Hlavacek,et al.  BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains , 2004, Bioinform..

[22]  Arup K Chakraborty,et al.  CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse , 2004, Nature Immunology.

[23]  W. S. Hlavacek,et al.  Mathematical and computational models of immune-receptor signalling , 2004, Nature Reviews Immunology.

[24]  Mark M Davis,et al.  T cell killing does not require the formation of a stable mature immunological synapse , 2004, Nature Immunology.

[25]  Bernhard Hemmer,et al.  TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways , 2003, Nature Immunology.

[26]  Mark M. Davis,et al.  Direct observation of ligand recognition by T cells , 2002, Nature.

[27]  Michael Loran Dustin,et al.  The immunological synapse , 2002, Arthritis research.

[28]  Michael Loran Dustin,et al.  T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.

[29]  B. Sefton,et al.  Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase* , 2001, The Journal of Biological Chemistry.

[30]  Cliburn Chan,et al.  Cooperative enhancement of specificity in a lattice of T cell receptors , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  W. Godwin.  Article in Press , 2000 .

[32]  M. Jackson,et al.  TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. , 1999, Science.

[33]  R. Germain,et al.  The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. , 1999, Annual review of immunology.

[34]  D. Fremont,et al.  High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. , 1998, Immunity.

[35]  A. Weiss,et al.  The Syk family of protein tyrosine kinases in T‐cell activation and development , 1998, Immunological reviews.

[36]  Mark M. Davis,et al.  LIGAND RECOGNITION BY T CELL RECEPTORS , 1998 .

[37]  Z Reich,et al.  Ligand recognition by alpha beta T cell receptors. , 1998, Annual review of immunology.

[38]  Hiroto Yamaguchi,et al.  Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation , 1996, Nature.

[39]  A. Masci,et al.  The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. Davis,et al.  Kinetic discrimination in T-cell activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. McKeithan,et al.  Kinetic proofreading in T-cell receptor signal transduction. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[42]  P. Allen,et al.  Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[43]  C. Walsh,et al.  Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells , 1994, Molecular and cellular biology.

[44]  A. Weiss,et al.  Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. , 1994, Science.

[45]  A. Weiss,et al.  The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. , 1994, Annual review of immunology.

[46]  M. Bevan,et al.  Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells , 1993, The Journal of experimental medicine.

[47]  M. Fournel,et al.  The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation. , 1990, Oncogene.

[48]  L. Samelson,et al.  Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck , 1989, Nature.

[49]  D. Gillespie.  Exact Stochastic Simulation of Coupled Chemical Reactions , 1977 .

[50]  E. Hill.  Journal of Theoretical Biology , 1961, Nature.