Ineffectiveness of prophylactic epsilon aminocaproic acid in severe hemophilia.

SUBSTANTIAL advances have been made in recent years in the treatment of hemorrhage and management of surgical situations in hemophilia by replacement therapy employing plasma and various plasma fractions. Replacement therapy, however, is not suitable as a preventive measure because of its short-lived corrective effect and the risk of inhibitor formation. Attempts to modify the disease have often resulted in enthusiastic promotion of new methods of therapy that lacked objectivity. For example, recent reports have indicated a beneficial effect of peanuts or peanut extracts in preventing or ameliorating hemorrhage in hemophilia.1 2 3 4 This was initially attributed to a vasoconstrictive effect by . . .