Biological function and molecular mechanism of piRNA in cancer

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

[1]  Michael Q. Zhang,et al.  The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. , 2002, Genes & development.

[2]  Yong Liu.  MicroRNAs and PIWI-interacting RNAs in oncology , 2016, Oncology letters.

[3]  D. Citrin,et al.  Multimodal management of muscle-invasive bladder cancer. , 2014, Current problems in cancer.

[4]  Thomas Tuschl,et al.  Discovery and Characterization of piRNAs in the Human Fetal Ovary. , 2015, Cell reports.

[5]  K. Mitsuya,et al.  Role for piRNAs and Noncoding RNA in de Novo DNA Methylation of the Imprinted Mouse Rasgrf1 Locus , 2011, Science.

[6]  I. Ng,et al.  Molecular Pathogenesis of Hepatocellular Carcinoma. , 2016, Liver cancer.

[7]  E. Miska,et al.  piRNAs: from biogenesis to function , 2014, Development.

[8]  Guilin Wang,et al.  PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses , 2016, Cancer Epidemiology, Biomarkers & Prevention.

[9]  Zhen Jiang,et al.  piRNA, the new non-coding RNA, is aberrantly expressed in human cancer cells. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[10]  A. Naccarati,et al.  Altered piRNA Profiles in Bladder Cancer: A New Challenge in the Next- Generation Sequencing Era? , 2017 .

[11]  Wan L. Lam,et al.  Piwi-interacting RNAs in cancer: emerging functions and clinical utility , 2016, Molecular Cancer.

[12]  MicroRNA dysregulation in gastric cancer. , 2012 .

[13]  S. Baylin,et al.  DNA methylation and gene silencing in cancer , 2005, Nature Clinical Practice Oncology.

[14]  R. Fehon,et al.  Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling. , 2011, Current opinion in cell biology.

[15]  Eugene Berezikov,et al.  A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish , 2007, Cell.

[16]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[17]  P. Alam.  ‘A’ , 2021, Composites Engineering: An A–Z Guide.

[18]  Alexander D. MacKerell,et al.  A piRNA-like small RNA interacts with and modulates p-ERM proteins in human somatic cells , 2015, Nature Communications.

[19]  A. Jemal,et al.  Cancer statistics, 2013 , 2013, CA: a cancer journal for clinicians.

[20]  M. Esteller.  Non-coding RNAs in human disease , 2011, Nature Reviews Genetics.

[21]  M. Coleman,et al.  Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study. , 2014, The Lancet. Oncology.

[22]  G. Chalbatani,et al.  Microrna a New Gate in Cancer and Human Disease: A Review , 2017 .

[23]  M. Siomi,et al.  Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines. , 2012, Genes & development.

[24]  M. Ebrahimi,et al.  CD166 as a stem cell marker? a potential target for therapy colorectal cancer? , 2016 .

[25]  P. Alam.  ‘T’ , 2021, Composites Engineering: An A–Z Guide.

[26]  Yon Hui Kim,et al.  Detection of PIWI and piRNAs in the mitochondria of mammalian cancer cells. , 2014, Biochemical and biophysical research communications.

[27]  Haifan Lin,et al.  PIWI proteins and their interactors in piRNA biogenesis, germline development and gene expression. , 2014, National science review.

[28]  W. Liu,et al.  A piRNA-like Small RNA Induces Chemoresistance to Cisplatin-Based Therapy by Inhibiting Apoptosis in Lung Squamous Cell Carcinoma , 2017, Molecular therapy. Nucleic acids.

[29]  Sung-Chou Li,et al.  MicroRNA dysregulation in gastric cancer. , 2012, Current pharmaceutical design.

[30]  Danna Zhou,et al.  d. , 1840, Microbial pathogenesis.

[31]  Rebecca L. Siegel Mph,et al.  Cancer statistics, 2016 , 2016 .

[32]  Gorjan Alagic,et al.  #p , 2019, Quantum information & computation.

[33]  H. Chang,et al.  Clinicopathologic Implications of PIWIL2 Expression in Colorectal Cancer , 2012, Korean journal of pathology.

[34]  P. Zamore,et al.  Small silencing RNAs: an expanding universe , 2009, Nature Reviews Genetics.

[35]  Michael Snyder,et al.  A major epigenetic programming mechanism guided by piRNAs. , 2013, Developmental cell.

[36]  Haifan Lin,et al.  An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster , 2007, Nature.

[37]  M. Siomi,et al.  Piwi-interacting RNAs: biological functions and biogenesis. , 2013, Essays in biochemistry.

[38]  Ahmedin Jemal,et al.  Annual Report to the Nation on the Status of Cancer, 1975‐2012, featuring the increasing incidence of liver cancer , 2016, Cancer.

[39]  Mikiko C. Siomi,et al.  The Discovery of Rna Interference (rnai) Biogenesis of Small Rnas on the Road to Reading the Rna-interference Code Insight Review , 2022 .

[40]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[41]  Chris Sander,et al.  A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity , 2012, Cell.

[42]  Li Mao,et al.  Novel dimensions of piRNAs in cancer. , 2013, Cancer letters.

[43]  P. Alam.  ‘L’ , 2021, Composites Engineering: An A–Z Guide.

[44]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[45]  B. Xiao,et al.  Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers. , 2010, Clinical biochemistry.

[46]  M. Ebrahimi,et al.  Molecular Mechanisms and Biological Functions of siRNA , 2017, International journal of biomedical science : IJBS.

[47]  Meilin Wang,et al.  Genetic variants in noncoding PIWI‐interacting RNA and colorectal cancer risk , 2015, Cancer.

[48]  Tongzhang Zheng,et al.  PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome. , 2015, Carcinogenesis.

[49]  Demosthenes B Panagiotakos,et al.  Optimizing diet and nutrition for cancer survivors: A review. , 2017, Maturitas.

[50]  Chao Qin,et al.  Identification of novel piRNAs in bladder cancer. , 2015, Cancer letters.

[51]  P. Alam.  ‘N’ , 2021, Composites Engineering: An A–Z Guide.

[52]  B. Baradaran,et al.  MiR-146a functions as a small silent player in gastric cancer. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[53]  C. Sander,et al.  A novel class of small RNAs bind to MILI protein in mouse testes , 2006, Nature.

[54]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[55]  Celina E. Juliano,et al.  Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organisms. , 2011, Annual review of genetics.

[56]  Jia Cheng,et al.  piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells. , 2012, Cancer letters.

[57]  N. Wong,et al.  Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma. , 2013, Journal of hepatology.

[58]  M. Ebrahimi,et al.  In Silico Analysis, Cloning and Expression of Recombinant CD166 in E. coliBL21 (DE3) as a Marker for Detection and Treatment of Colorectal Cancer , 2017 .

[59]  O. Klimenko.  Small non-coding RNAs as regulators of structural evolution and carcinogenesis , 2017, Non-coding RNA research.

[60]  He Huang,et al.  Clinicopathological and prognostic significance of FoxM1 in gastric cancer: A meta-analysis. , 2017, International journal of surgery.

[61]  Caroline Dive,et al.  Progress and prospects of early detection in lung cancer , 2017, Open Biology.

[62]  장윤희,et al.  Y. , 2003, Industrial and Labor Relations Terms.

[63]  R. Subramaniam,et al.  PET/Computed Tomography and Precision Medicine: Gastric Cancer. , 2017, PET clinics.

[64]  P. Alam,et al.  H , 1887, High Explosives, Propellants, Pyrotechnics.

[65]  Vladimir Gvozdev,et al.  A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline , 2006, Science.

[66]  Yuan Li,et al.  PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer , 2017, Cellular Physiology and Biochemistry.

[67]  M. Griswold,et al.  Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control1 , 2008, Biology of reproduction.

[68]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[69]  T. Xia,et al.  Non-coding RNAs and gastric cancer. , 2014, World journal of gastroenterology.

[70]  P. Molloy,et al.  DNA hypomethylation and human diseases. , 2007, Biochimica et biophysica acta.

[71]  H. Zhang,et al.  The expression of stem cell protein Piwil2 and piR-932 in breast cancer. , 2013, Surgical oncology.

[72]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[73]  A. Aravin,et al.  PIWI-interacting small RNAs: the vanguard of genome defence , 2011, Nature Reviews Molecular Cell Biology.

[74]  R. Fehon,et al.  Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. , 2009, Trends in cell biology.

[75]  S. Siddiqi,et al.  Piwis and piwi‐interacting RNAs in the epigenetics of cancer , 2012, Journal of cellular biochemistry.

[76]  Leonard D. Goldstein,et al.  piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans , 2012, Cell.

[77]  D. Moazed.  Small RNAs in transcriptional gene silencing and genome defence , 2009, Nature.

[78]  S. Shen,et al.  Altered expression of piRNAs and their relation with clinicopathologic features of breast cancer , 2013, Clinical and Translational Oncology.

[79]  M. Siomi,et al.  PIWI-Interacting RNA: Its Biogenesis and Functions. , 2015, Annual review of biochemistry.

[80]  P. Alam,et al.  R , 1823, The Herodotus Encyclopedia.

[81]  Manolis Kellis,et al.  Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila , 2007, Cell.

[82]  R. Ketting,et al.  The role of small non-coding RNAs in genome stability and chromatin organization , 2010, Journal of Cell Science.

[83]  L. Kiemeney,et al.  The present and future burden of urinary bladder cancer in the world , 2009, World Journal of Urology.