Organic anion transport is the primary function of the SLC17/type I phosphate transporter family

Recently, molecular studies have determined that the SLC17/type I phosphate transporters, a family of proteins initially characterized as phosphate carriers, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitter glutamate to the degradation and metabolism of glycoproteins.

[1]  A. Gray,et al.  Amino acid transport system A resembles system N in sequence but differs in mechanism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[2]  H. Murer,et al.  Proximal tubular phosphate reabsorption: molecular mechanisms. , 2000, Physiological reviews.

[3]  M. Schäfer,et al.  Molecular Cloning and Functional Identification of Mouse Vesicular Glutamate Transporter 3 and Its Expression in Subsets of Novel Excitatory Neurons* , 2002, The Journal of Biological Chemistry.

[4]  D. Copenhagen,et al.  The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[5]  S. Paul,et al.  Cloning and expression of a cDNA encoding a brain-specific Na(+)-dependent inorganic phosphate cotransporter. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[6]  B. Giros,et al.  The Existence of a Second Vesicular Glutamate Transporter Specifies Subpopulations of Glutamatergic Neurons , 2001, The Journal of Neuroscience.

[7]  Y. Minemoto,et al.  p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. , 2000, Biochemical and biophysical research communications.

[8]  F. Verheijen,et al.  Purification of the Lysosomal Sialic Acid Transporter , 1998, The Journal of Biological Chemistry.

[9]  L. Peltonen,et al.  Unraveling the molecular pathogenesis of free sialic acid storage disorders: altered targeting of mutant sialin. , 2002, Molecular genetics and metabolism.

[10]  Peter J. van der Spek,et al.  A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases , 1999, Nature Genetics.

[11]  L. Peltonen,et al.  The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation. , 2000, American journal of human genetics.

[12]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[13]  H. Galjaard,et al.  Functional reconstitution of the lysosomal sialic acid carrier into proteoliposomes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[14]  H. Yamada,et al.  Secretory Granule-mediated Co-secretion ofl-Glutamate and Glucagon Triggers Glutamatergic Signal Transmission in Islets of Langerhans* , 2003, The Journal of Biological Chemistry.

[15]  Y. Moriyama,et al.  Differentiation-associated Na+-dependent Inorganic Phosphate Cotransporter (DNPI) Is a Vesicular Glutamate Transporter in Endocrine Glutamatergic Systems* , 2001, The Journal of Biological Chemistry.

[16]  R. Wolff,et al.  A 1.1-Mb transcript map of the hereditary hemochromatosis locus. , 1997, Genome research.

[17]  Glutamate uptake system in the presynaptic vesicle: Glutamic acid analogs as inhibitors and alternate substrates , 2004, Neurochemical Research.

[18]  M. Schäfer,et al.  Identification of the Differentiation-Associated Na+/PI Transporter as a Novel Vesicular Glutamate Transporter Expressed in a Distinct Set of Glutamatergic Synapses , 2002, The Journal of Neuroscience.

[19]  G. Semenza,et al.  Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[20]  T. Ueda,et al.  Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal , 2001, Journal of neurochemistry.

[21]  E. Takeda,et al.  Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1. , 1998, The Journal of pharmacology and experimental therapeutics.

[22]  H. Yamamoto,et al.  Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression. , 1995, The Biochemical journal.

[23]  D. Copenhagen,et al.  Molecular Analysis of System N Suggests Novel Physiological Roles in Nitrogen Metabolism and Synaptic Transmission , 1999, Cell.

[24]  A. Werner,et al.  Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules , 1993, Pflügers Archiv.

[25]  R. Jahn,et al.  An anion binding site that regulates the glutamate transporter of synaptic vesicles. , 1993, The Journal of biological chemistry.

[26]  R. Fremeau,et al.  Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. , 2000, Science.

[27]  T Hori,et al.  Molecular Cloning of a Novel Brain‐Type Na+‐Dependent Inorganic Phosphate Cotransporter , 2000, Journal of neurochemistry.

[28]  M. Yaniv,et al.  Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. , 2002, Journal of molecular biology.

[29]  H. Horvitz,et al.  EAT-4, a Homolog of a Mammalian Sodium-Dependent Inorganic Phosphate Cotransporter, Is Necessary for Glutamatergic Neurotransmission in Caenorhabditis elegans , 1999, The Journal of Neuroscience.

[30]  Takeshi Kaneko,et al.  Complementary distribution of vesicular glutamate transporters in the central nervous system , 2002, Neuroscience Research.

[31]  V. Pickel,et al.  The Localization of the Brain-Specific Inorganic Phosphate Transporter Suggests a Specific Presynaptic Role in Glutamatergic Transmission , 1998, The Journal of Neuroscience.

[32]  P. Genever,et al.  Glutamate signalling in non-neuronal tissues. , 2001, Trends in pharmacological sciences.

[33]  S. Sugano,et al.  Isolation and chromosomal mapping of a novel human gene showing homology to Na+/PO4 cotransporter , 1999, Journal of Human Genetics.

[34]  H. Galjaard,et al.  Characterization of a proton-driven carrier for sialic acid in the lysosomal membrane. Evidence for a group-specific transport system for acidic monosaccharides. , 1989, The Journal of biological chemistry.

[35]  L. de Meis,et al.  Regulation of Glutamate Transport into Synaptic Vesicles by Chloride and Proton Gradient (*) , 1996, The Journal of Biological Chemistry.

[36]  P. Malherbe,et al.  Molecular cloning and functional characterization of human vesicular glutamate transporter 3 , 2002, EMBO reports.

[37]  T. Ueda,et al.  A protein factor that inhibits ATP-dependent glutamate and gamma-aminobutyric acid accumulation into synaptic vesicles: purification and initial characterization. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[38]  J. Matthews,et al.  Glutamate transport and renal function. , 1999, American journal of physiology. Renal physiology.

[39]  Christian Rosenmund,et al.  Identification of Differentiation-Associated Brain-Specific Phosphate Transporter as a Second Vesicular Glutamate Transporter (VGLUT2) , 2001, The Journal of Neuroscience.

[40]  B. Giros,et al.  A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons , 2002, The Journal of Neuroscience.

[41]  J. Collins,et al.  Molecular and Functional Analysis of a Novel Neuronal Vesicular Glutamate Transporter* , 2001, The Journal of Biological Chemistry.

[42]  R. Greger,et al.  Localization of NaPi-1, a Na-Pi cotransporter, in rabbit kidney proximal tubules , 1993, Pflügers Archiv.

[43]  F. Ghishan,et al.  Characterization of vesicular glutamate transporter in pancreatic α- and β-cells and its regulation by glucose , 2003 .

[44]  S. Bröer,et al.  Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  S. Bröer,et al.  Chloride Conductance and Pi Transport are Separate Functions Induced by the Expression of NaPi-1 in Xenopus Oocytes , 1998, The Journal of Membrane Biology.

[46]  J. Storm-Mathisen,et al.  The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse , 2001, Neuron.

[47]  F. Fonnum,et al.  Uptake of l‐Glutamate into Rat Brain Synaptic Vesicles: Effect of Inhibitors that Bind Specifically to the Glutamate Transporter , 1995, Journal of neurochemistry.