A Composite Lymphoma Consisting of a Mantle Cell Lymphoma and a Peripheral T-Cell Lymphoma: A Rare Case With Literature Review

A composite lymphoma (CL) is defined as 2 or more morphologically and immunophenotypically distinct lymphomas or lymphoid neoplasms that occur in the same organ or tissue. Many types of CL have been described in the literature, including 52 cases of CL with a component of mantle cell lymphoma (MCL) and only 2 cases of CL consisting of MCL and T-cell lymphoma. We hereby present a case of CL consisting of MCL and peripheral T-cell lymphoma, not otherwise specified. Morphologic features and flow cytometry analysis were both instrumental in the diagnosis of CL. In addition, we reviewed 52 reported cases of CLwithMCL as a component. We found that the proliferation patterns of MCL have a relationship with the other component of the CL. We also found that many patients with CL had a history of lymphoproliferative disorders including lymphomas; this was observed in 9 of 52 cases, including 5 cases of MCL and 2 cases of another component of CL. This rate (approximately 17%) is relatively high and should not be ignored.

[1]  H. Sasano,et al.  Non-biased and complete case registration of lymphoid leukemia and lymphoma for five years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture , 2017, Leukemia & lymphoma.

[2]  R. Antonelli Incalzi,et al.  Composite Mantle‐Cell Lymphoma and Classical Hodgkin Lymphoma in a Very Old Adult , 2015, Journal of the American Geriatrics Society.

[3]  D. LeBrun,et al.  Composite mantle cell and primary cutaneous anaplastic large cell lymphoma: case report and review of the literature. , 2015, The American Journal of dermatopathology.

[4]  A. Bagg,et al.  Multifocal mantle cell lymphoma in situ in the setting of a composite lymphoma. , 2015, American journal of clinical pathology.

[5]  Liuyan Jiang,et al.  Mantle cell lymphoma and diffuse large B‐cell lymphoma of the testis: a unique case of composite non‐Hodgkin lymphoma , 2014, European journal of haematology.

[6]  J. Taverna,et al.  A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature , 2014, Case reports in hematology.

[7]  Q. Yan,et al.  A unique composite follicular lymphoma and mantle cell lymphoma with a mixed cell pattern and aggressive course. , 2014, American journal of clinical pathology.

[8]  C. Rehder,et al.  Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. , 2014, Human pathology.

[9]  B. Falini,et al.  Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B‐cell‐derived mantle cell lymphoma , 2014, International journal of cancer.

[10]  K. Young,et al.  Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. , 2013, Human pathology.

[11]  M. Dominis,et al.  Follicular and Mantle Cell Lymphoma Characteristics Present Simultaneously in the Same Lymph Node , 2013, Applied immunohistochemistry & molecular morphology : AIMM.

[12]  松岡 亮仁,et al.  Composite lymphoma consisting of mantle cell lymphoma and follicular lymphoma , 2013 .

[13]  E. Ranheim,et al.  A Unique “Composite” PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant , 2013, Case reports in hematology.

[14]  Michael L. Wang,et al.  Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a clinicopathologic and molecular study. , 2013, Human pathology.

[15]  Michael L. Wang,et al.  Mantle cell lymphoma as a component of composite lymphoma: clinicopathologic parameters and biologic implications. , 2012, Human pathology.

[16]  R. Miles,et al.  Composite Mantle Cell and Diffuse Large B-Cell Lymphoma , 2011, International journal of surgical pathology.

[17]  L. Bonello,et al.  Usefulness of multiparametric flow cytometry in detecting composite lymphoma: study of 17 cases in a 12-year period. , 2011, American journal of clinical pathology.

[18]  T. Kourelis,et al.  Treatment of Synchronous Mantle Cell Lymphoma and Small Lymphocytic Lymphoma with Bendamustine and Rituximab , 2011, Acta Haematologica.

[19]  W. Chan,et al.  Molecular Characteristics of Mantle Cell Lymphoma Presenting With Clonal Plasma Cell Component , 2011, The American journal of surgical pathology.

[20]  P. Gameiro,et al.  Mantle cell lymphoma and chronic lymphocytic leukemia: report of a rare disease association and review of the literature , 2010 .

[21]  A. Bagg,et al.  Coexisting follicular and mantle cell lymphoma with each having an in situ component: A novel, curious, and complex consultation case of coincidental, composite, colonizing lymphoma. , 2010, American journal of clinical pathology.

[22]  J. Thomas,et al.  Synchronous Mantle Cell Lymphoma, Chronic Lymphocytic Leukaemia and Melanoma in a Single Lymph Node , 2010, Acta Haematologica.

[23]  R. Michel,et al.  Composite Cutaneous Lymphoma in a Patient With Rheumatoid Arthritis Treated With Methotrexate , 2010, The American Journal of dermatopathology.

[24]  M. Tsukaguchi,et al.  [Picture in clinical hematology no. 39: composite hodgkin lymphoma and mantle cell lymphoma]. , 2009, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[25]  T. Molina,et al.  Composite mantle cell and follicular lymphoma. A case report. , 2009, Human pathology.

[26]  R. Collins,et al.  A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma. , 2008, Human pathology.

[27]  K. Naresh,et al.  In‐situ mantle cell lymphoma—a report of two cases , 2007, Histopathology.

[28]  W. Cooper,et al.  Extranodal plasmablastic lymphoma arising in mantle cell lymphoma , 2007, Histopathology.

[29]  N. Mokhtar.  Review article composite lymphoma. , 2007, Journal of the Egyptian National Cancer Institute.

[30]  M. Callanan,et al.  Composite splenic marginal zone lymphoma and mantle cell lymphoma arising from 2 independent B-cell clones. , 2007, Human pathology.

[31]  J. Kutok,et al.  Mantle cell lymphoma arising within primary nodal marginal zone lymphoma: a unique presentation of two uncommon B-cell lymphoproliferative disorders. , 2006, Cancer genetics and cytogenetics.

[32]  S. Hayes,et al.  Composite mantle‐cell lymphoma and classical Hodgkin lymphoma , 2006, Histopathology.

[33]  G. Ott,et al.  Molecular characterization of composite mantle cell and follicular lymphoma , 2006, Virchows Archiv.

[34]  C. Shields,et al.  Mantle Cell Lymphoma in the Ocular Adnexal Region , 2006 .

[35]  C. Felten,et al.  Burkitt Transformation of Mantle Cell Lymphoma , 2004, Leukemia & lymphoma.

[36]  Juan F. García,et al.  Composite Hodgkin Lymphoma and Mantle Cell Lymphoma: Two Clonally Unrelated Tumors , 2003, The American journal of surgical pathology.

[37]  R. Küppers,et al.  Analysis of a Clonally Related Mantle Cell and Hodgkin Lymphoma Indicates Epstein-Barr Virus Infection of a Hodgkin/Reed-Sternberg Cell Precursor in a Germinal Center , 2003, The American journal of surgical pathology.

[38]  Ana Helena Santos,et al.  Guess what: Chronic 13q14.3+/CD5−/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23− mantle cell lymphoma in lymph nodes! , 2003, Cytometry. Part B, Clinical cytometry.

[39]  E. Cesarman,et al.  A distinctive composite lymphoma consisting of clonally related mantle cell lymphoma and follicle center cell lymphoma. , 1999, Human pathology.

[40]  E. Jaffe,et al.  Composite low grade B-cell lymphomas with two immunophenotypically distinct cell populations are true biclonal lymphomas. A molecular analysis using laser capture microdissection. , 1999, The American journal of pathology.

[41]  P. Isaacson,et al.  Composite mantle-cell lymphoma and plasmacytoma. , 1997, Human pathology.

[42]  R. Sinclair,et al.  Composite lymphoma. , 1986, American journal of clinical pathology.