Anatomical Segregation of Visual Selection Mechanisms in Human Parietal Cortex

Visual selection requires mechanisms for representing object salience and for shifting the focus of processing to novel objects. It is not clear from computational or neural models whether these operations are performed within the same or different brain regions. Here, we use repetitive transcranial magnetic stimulation to briefly interfere with neural activity in individually localized regions of human posterior parietal cortex (PPC) that are putatively involved in attending to contralateral locations or shifting attention between locations. Stimulation over right ventral intraparietal sulcus impaired target discrimination at contralateral locations, whereas stimulation over right medial superior parietal lobule impaired target discrimination after a shift of attention regardless of its location. This double dissociation is consistent with neuroimaging studies and indicates that mechanisms of visual selection are partly anatomically segregated in human PPC.

[1]  D H Brainard,et al.  The Psychophysics Toolbox. , 1997, Spatial vision.

[2]  J. de Ajuriaguerra,et al.  Balint's syndrome (psychic paralysis of visual fixation) and its minor forms. , 1954, Brain : a journal of neurology.

[3]  S Ullman,et al.  Shifts in selective visual attention: towards the underlying neural circuitry. , 1985, Human neurobiology.

[4]  S. Yantis,et al.  Transient neural activity in human parietal cortex during spatial attention shifts , 2002, Nature Neuroscience.

[5]  S. Yantis,et al.  A Domain-Independent Source of Cognitive Control for Task Sets: Shifting Spatial Attention and Switching Categorization Rules , 2009, The Journal of Neuroscience.

[6]  M. Corbetta,et al.  Interaction of Stimulus-Driven Reorienting and Expectation in Ventral and Dorsal Frontoparietal and Basal Ganglia-Cortical Networks , 2009, The Journal of Neuroscience.

[7]  B. Wandell,et al.  Visual Field Maps in Human Cortex , 2007, Neuron.

[8]  Maurizio Corbetta,et al.  Asymmetry of Anticipatory Activity in Visual Cortex Predicts the Locus of Attention and Perception , 2007, The Journal of Neuroscience.

[9]  M. Corbetta,et al.  Spatial neglect and attention networks. , 2011, Annual review of neuroscience.

[10]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[11]  S. Kastner,et al.  Topographic maps in human frontal and parietal cortex , 2009, Trends in Cognitive Sciences.

[12]  S. Yantis,et al.  Control of Attention Shifts between Vision and Audition in Human Cortex , 2004, The Journal of Neuroscience.

[13]  Céline R. Gillebert,et al.  Parcellation of parietal cortex: Convergence between lesion-symptom mapping and mapping of the intact functioning brain , 2009, Behavioural Brain Research.

[14]  D. V. van Essen,et al.  A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. , 2005, NeuroImage.

[15]  Xiaogang Yan,et al.  Specificity of Human Parietal Saccade and Reach Regions during Transcranial Magnetic Stimulation , 2010, The Journal of Neuroscience.

[16]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[17]  Céline R. Gillebert,et al.  Spatial attention deficits in humans: The critical role of superior compared to inferior parietal lesions , 2012, Neuropsychologia.

[18]  M. Corbetta,et al.  Separating Processes within a Trial in Event-Related Functional MRI I. The Method , 2001, NeuroImage.

[19]  Daryl E. Wilson,et al.  Control of Spatial and Feature-Based Attention in Frontoparietal Cortex , 2010, The Journal of Neuroscience.

[20]  Bruno A Olshausen,et al.  Sparse coding of sensory inputs , 2004, Current Opinion in Neurobiology.

[21]  C. Koch,et al.  Computational modelling of visual attention , 2001, Nature Reviews Neuroscience.

[22]  George R. Mangun,et al.  Right temporoparietal junction activation by a salient contextual cue facilitates target discrimination , 2011, NeuroImage.

[23]  M. Corbetta,et al.  Separating Processes within a Trial in Event-Related Functional MRI II. Analysis , 2001, NeuroImage.

[24]  Leslie G. Ungerleider,et al.  Mechanisms of visual attention in the human cortex. , 2000, Annual review of neuroscience.

[25]  P. Rossini,et al.  Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. , 1994, Electroencephalography and clinical neurophysiology.

[26]  M. Corbetta,et al.  Frontoparietal Cortex Controls Spatial Attention through Modulation of Anticipatory Alpha Rhythms , 2009, The Journal of Neuroscience.

[27]  A. Cavanna,et al.  The precuneus: a review of its functional anatomy and behavioural correlates. , 2006, Brain : a journal of neurology.

[28]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[29]  Maurizio Corbetta,et al.  Distinct representations for shifts of spatial attention and changes of reward contingencies in the human brain , 2013, Cortex.

[30]  S. Rossi,et al.  Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research , 2009, Clinical Neurophysiology.

[31]  M. Behrmann,et al.  Top-down and bottom-up attentional guidance: investigating the role of the dorsal and ventral parietal cortices , 2010, Experimental Brain Research.

[32]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.