Molecular recognition by cyclodextrin dimers

Abstract Cyclodextrin dimers strongly bind substrates with the correct geometry in water solution. Studies with antihydrophobic agents help clarify the factors involved.

[1]  Ronald Breslow,et al.  Strong binding of ditopic substrates by a doubly linked occlusive C1 clamshell as distinguished from an aversive C2 loveseat cyclodextrin dimer , 1990 .

[2]  M. Baudler Transition Metals. (Book Reviews: An Introduction to Transition-Metal Chemistry. Ligand Field Theory) , 1960 .

[3]  E. Kool,et al.  Dichotomous salt effects in the hydrophobic acceleration of the benzoin condensation , 1988 .

[4]  R. Breslow Bifunctional binding and catalysis , 1993 .

[5]  R. Breslow,et al.  Very strong binding of appropriate substrates by cyclodextrin dimers , 1989 .

[6]  S. Malik,et al.  Nonpolar Group Participation in the Denaturation of Proteins by Urea and Guanidinium Salts. Model Compound Studies , 1964 .

[7]  R. Breslow,et al.  Enthalpic domination of the chelate effect in cyclodextrin dimers , 1993 .

[8]  T. Nabeshima,et al.  Characterization of regiospecific AC- and AD-disulfonate capping of .beta.-cyclodextrin. Capping as an efficient production technique , 1984 .

[9]  Charles Tanford,et al.  The hydrophobic effect , 1980 .

[10]  R. Breslow,et al.  Lyophobic binding of substrates by cyclodextrins in nonaqueous solvents , 1975 .

[11]  D. Kristol,et al.  Cyclodextrin inclusion complexes: studies of the variation in the size of alicyclic guests , 1989 .

[12]  A. Harada,et al.  Cooperative Binding by Cyclodextrin Dimers , 1980 .

[13]  Maurice R. Eftink,et al.  Cyclodextrin–adamantanecarboxylate inclusion complexes: A model system for the hydrophobic effect , 1982 .

[14]  Dan Yang,et al.  Artificial Transaminases Linking Pyridoxamine to Binding Cavities: Controlling the Geometry , 1990 .

[15]  Ronald Breslow,et al.  Hydrophobic Effects on Simple Organic Reactions in Water , 1991 .

[16]  C. Rizzo,et al.  CHAOTROPIC SALT EFFECTS IN A HYDROPHOBICALLY ACCELERATED DIELS-ALDER REACTION , 1991 .

[17]  P. V. Hippel,et al.  Ion effects on the solution structure of biological macromolecules , 1969 .

[18]  J F Brandts,et al.  Rapid measurement of binding constants and heats of binding using a new titration calorimeter. , 1989, Analytical biochemistry.

[19]  R. Breslow,et al.  Very fast ester hydrolysis by a cyclodextrin dimer with a catalytic linking group , 1992 .

[20]  Ronald Breslow,et al.  Geometric evidence on the ribonuclease model mechanism , 1989 .

[21]  Yoshihisa Inoue,et al.  Thermodynamics of molecular recognition by cyclodextrins. 1. Calorimetric titration of inclusion complexation of naphthalenesulfonates with .alpha.-, .beta.-, and .gamma.-cyclodextrins: enthalpy-entropy compensation , 1993 .