A Modular Multilevel Voltage-Boosting Marx Pulse-Waveform Generator for Electroporation Applications

In order to overcome the limitations of the existing classical and solid-state Marx pulse generators, this paper proposes a new modular multilevel voltage-boosting Marx pulse generator (BMPG). The proposed BMPG has hardware features that allow modularity, redundancy, and scalability as well as operational features that alleviate the need of series-connected switches and allows generation of a wide range of pulse waveforms. In the BMPG, a controllable, low-voltage input boost converter supplies, via directing/blocking (D/B) diodes, two arms of a series modular multilevel converter half-bridge sub-modules (HB-SMs). At start up, all the arm's SM capacitors are resonantly charged in parallel from 0 V, simultaneously via directing diodes, to a voltage in excess of the source voltage. After the first pulse delivery, the energy of the SM capacitors decreases due to the generated pulse. Then, for continuous operation without fully discharging the SM capacitors or having a large voltage droop as in the available Marx generators, the SM capacitors are continuously recharged in parallel, to the desired boosted voltage level. Because all SMs are parallelly connected, the boost converter duty ratio is controlled by a single voltage measurement at the output terminals of the boost converter. Due to the proposed SMs structure and the utilization of D/B diodes, each SM capacitor is effectively controlled individually without requiring a voltage sensor across each SM capacitor. Generation of the commonly used pulse waveforms in electroporation applications is possible, while assuring balanced capacitors, hence SM voltages. The proposed BMPG has several topological variations such as utilizing a buck–boost converter at the input stage and replacing the HB-SM with full-bridge SMs. The proposed BMPG topology is assessed by simulation and scaled-down proof-of-concept experimentation to explore its viability for electroporation applications.

[1]  Abdolreza Sheikholeslami,et al.  Modular switched capacitor voltage multiplier topology for pulsed power supply , 2014, IEEE Transactions on Dielectrics and Electrical Insulation.

[2]  K. Schoenbach,et al.  The effect of pulsed electric fields on biological cells: experiments and applications , 1997 .

[3]  Luis Lamy Rocha,et al.  Multilevel High-Voltage Pulse Generation Based on a New Modular Solid-State Switch , 2014, IEEE Transactions on Plasma Science.

[4]  Stephen J. Finney,et al.  A Step-Up Modular High-Voltage Pulse Generator Based on Isolated Input-Parallel/Output-Series Voltage-Boosting Modules and Modular Multilevel Submodules , 2019, IEEE Transactions on Industrial Electronics.

[5]  H. Canacsinh,et al.  Marx-Type Solid-State Bipolar Modulator Topologies: Performance Comparison , 2012, IEEE Transactions on Plasma Science.

[6]  Ahmed M. Massoud,et al.  A high voltage pulse-generator based on DC-to-DC converters and capacitor-diode voltage multipliers for water treatment applications , 2015, IEEE Transactions on Dielectrics and Electrical Insulation.

[7]  Chenguo Yao,et al.  FPGA-Controlled All-Solid-State Nanosecond Pulse Generator for Biological Applications , 2012, IEEE Transactions on Plasma Science.

[8]  S. Ahmed,et al.  Energy in smart grid: Strategies and technologies for efficiency enhancement , 2015, 2015 First Workshop on Smart Grid and Renewable Energy (SGRE).

[9]  B. Williams,et al.  High‐voltage pulse generator based on sequentially charged MMC‐SMs operating in a voltage‐boost mode , 2019, IET Power Electronics.

[10]  Ahmed M. Massoud,et al.  A Transformerless Bipolar/Unipolar High-Voltage Pulse Generator With Low-Voltage Components for Water Treatment Applications , 2017, IEEE Transactions on Industry Applications.

[11]  Damijan Miklavčič,et al.  Advantages and Disadvantages of Different Concepts of Electroporation Pulse Generation , 2011 .

[12]  L M Redondo A DC Voltage-Multiplier Circuit Working as a High-Voltage Pulse Generator , 2010, IEEE Transactions on Plasma Science.

[13]  Barry W. Williams,et al.  A Modular Multilevel Generic Pulse-Waveform Generator for Pulsed Electric Field Applications , 2017, IEEE Transactions on Plasma Science.

[14]  Abdolreza Sheikholeslami,et al.  High-Voltage Pulsed Power Supply to Generate Wide Pulses Combined With Narrow Pulses , 2014, IEEE Transactions on Plasma Science.

[15]  Ahmed Elserougi,et al.  A boost converter-based ringing circuit with high-voltage gain for unipolar pulse generation , 2016, IEEE Transactions on Dielectrics and Electrical Insulation.

[16]  J. F. Silva,et al.  Dual Resonant Voltage Droop Compensation for Bipolar Solid-State Marx Generator Topologies , 2018, IEEE Transactions on Plasma Science.

[17]  Ravindra P. Joshi,et al.  Bacterial decontamination of liquids with pulsed electric fields , 2000 .

[18]  H. Akiyama,et al.  A Repetitive Solid State Marx-Type Pulsed Power Generator Using Multistage Switch-Capacitor Cells , 2012, IEEE Transactions on Plasma Science.

[19]  John C. Bischof,et al.  A Review of Basic to Clinical Studies of Irreversible Electroporation Therapy , 2015, IEEE Transactions on Biomedical Engineering.

[20]  Shesha H. Jayaram,et al.  Sterilization of liquid foods by pulsed electric fields , 2000 .

[21]  J. Fernando Silva,et al.  Seven-Level Unipolar/Bipolar Pulsed Power Generator , 2016, IEEE Transactions on Plasma Science.

[22]  Barry W. Williams,et al.  A High-Gain, High-Voltage Pulse Generator Using Sequentially Charged Modular Multilevel Converter Submodules, for Water Disinfection Applications , 2018, IEEE Journal of Emerging and Selected Topics in Power Electronics.

[23]  Ahmed M. Massoud,et al.  A Modular High-Voltage Pulse-Generator With Sequential Charging for Water Treatment Applications , 2016, IEEE Transactions on Industrial Electronics.

[24]  A. S. Abdel-Khalik,et al.  Indirect field oriented control of five-phase induction motor based on SPWM-CSI , 2014, 2014 International Conference on Electrical Machines (ICEM).

[25]  Hector Sarnago,et al.  A Versatile Multilevel Converter Platform for Cancer Treatment Using Irreversible Electroporation , 2016, IEEE Journal of Emerging and Selected Topics in Power Electronics.

[26]  Ahmed M. Massoud,et al.  Modular Multilevel Converter-Based Bipolar High-Voltage Pulse Generator With Sensorless Capacitor Voltage Balancing Technique , 2016, IEEE Transactions on Plasma Science.

[27]  Ahmed M. Massoud,et al.  A Full-Bridge Submodule-Based Modular Unipolar/Bipolar High-Voltage Pulse Generator With Sequential Charging of Capacitors , 2017, IEEE Transactions on Plasma Science.

[28]  Ahmed M. Massoud,et al.  A Boost-Inverter-Based Bipolar High-Voltage Pulse Generator , 2017, IEEE Transactions on Power Electronics.

[29]  L. M. Redondo,et al.  New four-switches bipolar solid-state Marx generator , 2013, 2013 Abstracts IEEE International Conference on Plasma Science (ICOPS).

[30]  L.M. Redondo,et al.  Flyback Versus Forward Switching Power Supply Topologies For Unipolar Pulsed-Power Applications , 2009, IEEE Transactions on Plasma Science.

[31]  B. Rubinsky,et al.  Cell membrane electroporation-Part 2: the applications , 2013, IEEE Electrical Insulation Magazine.

[32]  B. Williams,et al.  Full-Bridge Modular Multilevel Submodule-Based High-Voltage Bipolar Pulse Generator With Low-Voltage DC, Input for Pulsed Electric Field Applications , 2017, IEEE Transactions on Plasma Science.

[33]  L.M. Redondo,et al.  High-voltage high-frequency Marx-bank type pulse generator using integrated power semiconductor half-bridges , 2005, 2005 European Conference on Power Electronics and Applications.

[34]  Barry W. Williams,et al.  A Transition Arm Modular Multilevel Universal Pulse-Waveform Generator for Electroporation Applications , 2017, IEEE Transactions on Power Electronics.

[35]  S.-Y. Tseng,et al.  Generation of pulsed electric fields for processing microbes , 2004 .

[36]  Abdolreza Sheikholeslami,et al.  A New Modular Bipolar High-Voltage Pulse Generator , 2017, IEEE Transactions on Industrial Electronics.

[37]  J. Clementson,et al.  Design of A, B, and C Pulse Forming Networks Using the VINPFN Application , 2014, IEEE Transactions on Power Electronics.

[38]  Barry W. Williams,et al.  A Modular Multilevel-Based High-Voltage Pulse Generator for Water Disinfection Applications , 2016, IEEE Transactions on Plasma Science.

[39]  Arindam Ghosh,et al.  A Novel High-Voltage Pulsed-Power Supply Based on Low-Voltage Switch–Capacitor Units , 2009 .

[40]  H. Bluhm Pulsed Power Systems: Principles and Applications , 2006 .