Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model

[1]  H. Zempel,et al.  Microtubule affinity regulating kinase (MARK/Par1) isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology , 2022, Neural regeneration research.

[2]  Bin Yu,et al.  Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system , 2022, Experimental Neurology.

[3]  S. Silvestre,et al.  Role of Aducanumab in the Treatment of Alzheimer’s Disease: Challenges and Opportunities , 2022, Clinical interventions in aging.

[4]  Xuezhong Li,et al.  Level of LncRNA GAS5 and Hippocampal Volume are Associated with the Progression of Alzheimer’s Disease , 2022, Clinical interventions in aging.

[5]  Xingchun Gou,et al.  Amyloid-beta targeted therapeutic approaches for Alzheimer's disease: long road ahead. , 2022, Current drug targets.

[6]  Rekha S. Patel,et al.  Long Noncoding RNA GAS5 Contained in Exosomes Derived from Human Adipose Stem Cells Promotes Repair and Modulates Inflammation in a Chronic Dermal Wound Healing Model , 2022, Biology.

[7]  F. D. De Felice,et al.  Impaired insulin signalling and allostatic load in Alzheimer disease , 2022, Nature Reviews Neuroscience.

[8]  M. Voso,et al.  Increased Plasma Levels of lncRNAs LINC01268, GAS5 and MALAT1 Correlate with Negative Prognostic Factors in Myelofibrosis , 2021, Cancers.

[9]  R. Dahlstrom,et al.  Challenges and opportunities , 2021, Foundations of a Sustainable Economy.

[10]  Yisheng Wang,et al.  RETRACTED ARTICLE: GAS5 knockdown alleviates spinal cord injury by reducing VAV1 expression via RNA binding protein CELF2 , 2021, Scientific Reports.

[11]  Nadezhda T. Doncheva,et al.  The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets , 2020, Nucleic Acids Res..

[12]  D. Bennett,et al.  Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia , 2021, PLoS genetics.

[13]  Xiaochuan Sun,et al.  Estrogen improved the regeneration of axons after subcortical axon injury via regulation of PI3K/Akt/CDK5/Tau pathway , 2020, Brain and behavior.

[14]  F. Wang,et al.  Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice , 2020, Brain and behavior.

[15]  L. Lipovich,et al.  The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers , 2019, Non-coding RNA.

[16]  M. Bagherzadeh,et al.  A Perspective to the Correlation Between Brain Insulin Resistance and Alzheimer: Medicinal Chemistry Approach. , 2019, Current diabetes reviews.

[17]  Vahideh Hassan-Zadeh,et al.  The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis , 2019, Clinical Rheumatology.

[18]  B. Fiebich,et al.  Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration , 2019, International journal of molecular sciences.

[19]  N. Patel,et al.  Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes. , 2019, Cell chemical biology.

[20]  Y. Sun,et al.  High expression of GAS5 promotes neuronal death after cerebral infarction by regulating miR-365a-3p. , 2018, European review for medical and pharmacological sciences.

[21]  Xiaoting Li,et al.  LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway. , 2018, Biochemical and biophysical research communications.

[22]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[23]  Boyle,et al.  Repurposing [ , 2018 .

[24]  W. Lukiw,et al.  Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain , 2017, Front. Immunol..

[25]  Dev Mehta,et al.  Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015 , 2017, Expert opinion on investigational drugs.

[26]  J. Mazar,et al.  The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma , 2016, Oncotarget.

[27]  V. Davey,et al.  Herbicide Exposure, Vietnam Service, and Hypertension Risk in Army Chemical Corps Veterans , 2016, Journal of occupational and environmental medicine.

[28]  T. Kino,et al.  Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases , 2016, Hormone and Metabolic Research.

[29]  Gwyn T. Williams,et al.  Reciprocal regulation of GAS 5 lncRNA levels and mTOR inhibitor action in prostate cancer cells , 2016 .

[30]  N. Patel,et al.  Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus , 2015, BBA clinical.

[31]  H. Malkki Alzheimer disease: Insulin resistance could be linked to risk of AD via reduced glucose uptake , 2015, Nature Reviews Neurology.

[32]  Gwyn T. Williams,et al.  Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells , 2015, The Prostate.

[33]  J. Rinn,et al.  Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution , 2015, Genome Biology.

[34]  N. El-Sayed,et al.  Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease. , 2015, Advances in experimental medicine and biology.

[35]  S. Martelossi,et al.  Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response. , 2015, Current molecular medicine.

[36]  C. Qin,et al.  The miR-545/374a Cluster Encoded in the Ftx lncRNA is Overexpressed in HBV-Related Hepatocellular Carcinoma and Promotes Tumorigenesis and Tumor Progression , 2014, PloS one.

[37]  M. Schuler,et al.  Prognostic Impact of Bcl-2 Depends on Tumor Histology and Expression of MALAT-1 lncRNA in Non–Small-Cell Lung Cancer , 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[38]  Qin Chen,et al.  lncRNA H19/miR‐675 axis represses prostate cancer metastasis by targeting TGFBI , 2014, The FEBS journal.

[39]  P. Moreira,et al.  Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia , 2014, Front. Endocrinol..

[40]  S. Ferreira,et al.  Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease , 2014, Diabetes.

[41]  S. Arnold,et al.  Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease , 2014, Diabetes.

[42]  R. Stahel,et al.  GAS5 long non-coding RNA in malignant pleural mesothelioma , 2014, Molecular Cancer.

[43]  Jie Yao,et al.  LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma. , 2014, International journal of clinical and experimental pathology.

[44]  C. DeCarli,et al.  Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy , 2014, Neurology.

[45]  Gwyn T. Williams,et al.  Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy , 2014, Breast Cancer Research and Treatment.

[46]  M. Mourtada-Maarabouni,et al.  Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. , 2013, Biochimica et biophysica acta.

[47]  N. Akimitsu,et al.  The RNA Degradation Pathway Regulates the Function of GAS5 a Non-Coding RNA in Mammalian Cells , 2013, PloS one.

[48]  R. L. Allison The long road ahead. , 2013, South Dakota medicine : the journal of the South Dakota State Medical Association.

[49]  S. Craft Alzheimer disease: Insulin resistance and AD—extending the translational path , 2012, Nature Reviews Neurology.

[50]  P. Bickford,et al.  Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform* , 2012, The Journal of Biological Chemistry.

[51]  K. Nakashima,et al.  [The Rotterdam study]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.

[52]  R. Morishita,et al.  Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. , 2011, Current aging science.

[53]  R. Morishita,et al.  Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. , 2011, Molecular bioSystems.

[54]  George Perry,et al.  Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease? , 2011, Ageing Research Reviews.

[55]  M. Schachner,et al.  Expression of the snoRNA host gene gas5 in the hippocampus is upregulated by age and psychogenic stress and correlates with reduced novelty‐induced behavior in C57BL/6 mice , 2010, Hippocampus.

[56]  Rajeev Prabhakar,et al.  Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study. , 2010, Biochemistry.

[57]  Han K. Kang,et al.  Mortality patterns of Army Chemical Corps veterans who were occupationally exposed to herbicides in Vietnam. , 2010, Annals of epidemiology.

[58]  G. Chrousos,et al.  Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor , 2010, Science Signaling.

[59]  松崎 尊信 Insulin resistance is associated with the pathology of Alzheimer's disease : the Hisayama study , 2010 .

[60]  R. Castellani,et al.  Alzheimer disease. , 2010, Disease-a-month : DM.

[61]  I. Grundke‐Iqbal,et al.  Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. , 2009, The American journal of pathology.

[62]  A. Hofman,et al.  Insulin metabolism and the risk of Alzheimer's disease: The Rotterdam Study , 2009, Alzheimer's & Dementia.

[63]  J. Moriguti,et al.  (Pre)diabetes, brain aging, and cognition. , 2009, Biochimica et biophysica acta.

[64]  M. Mourtada-Maarabouni,et al.  GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer , 2009, Oncogene.

[65]  H. Kuo,et al.  Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis , 2009, PloS one.

[66]  V. Haroutunian,et al.  Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology , 2008, Neurology.

[67]  J. Michalek,et al.  Diabetes and Cancer in Veterans of Operation Ranch Hand After Adjustment for Calendar Period, Days of Spraying, and Time Spent in Southeast Asia , 2008, Journal of occupational and environmental medicine.

[68]  R. Sidman,et al.  TLR8: An Innate Immune Receptor in Brain, Neurons and Axons , 2007, Cell cycle.

[69]  Eric M Reiman,et al.  Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. , 2007, Physiological genomics.

[70]  R. Sidman,et al.  Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis , 2006, The Journal of cell biology.

[71]  P. Riederer,et al.  Alzheimer‐like changes in protein kinase B and glycogen synthase kinase‐3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway , 2006, Journal of neurochemistry.

[72]  K. Ashe,et al.  Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) , 2005, The Journal of Neuroscience.

[73]  I. Grundke‐Iqbal,et al.  Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations* , 2004, Journal of Biological Chemistry.

[74]  D. Bennett,et al.  Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. , 2004, Archives of neurology.

[75]  Paul Pavlidis,et al.  Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. , 2004, Learning & memory.

[76]  J. Michalek,et al.  Serum dioxin and cognitive functioning among veterans of Operation Ranch Hand. , 2001, Neurotoxicology.

[77]  L. Philipson,et al.  The gas 5 gene shows four alternative splicing patterns without coding for a protein. , 2000, Gene.

[78]  J. Steitz,et al.  Classification of gas5 as a Multi-Small-Nucleolar-RNA (snoRNA) Host Gene and a Member of the 5′-Terminal Oligopyrimidine Gene Family Reveals Common Features of snoRNA Host Genes , 1998, Molecular and Cellular Biology.

[79]  G. Henriksen,et al.  Serum Dioxin and Diabetes Mellitus in Veterans of Operation Ranch Hand , 1997, Epidemiology.

[80]  Julia M. Goodfellow,et al.  Molecular dynamics study , 1997 .

[81]  E. Coccia,et al.  Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development , 1992 .

[82]  E. Coccia,et al.  Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. , 1992, Molecular and cellular biology.

[83]  S. Katsuki [Hisayama study]. , 1971, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

[84]  Y. Oshika,et al.  P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo. , 1996, British Journal of Cancer.