Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model
暂无分享,去创建一个
P. Bickford | N. Patel | S. Hill | C. Hudson | L. Blair | Rekha S. Patel | Yan Shi | Robert P. Sparks | Jianfeng Cai | Ashley Lui | L. Moss | Laura J. Blair
[1] H. Zempel,et al. Microtubule affinity regulating kinase (MARK/Par1) isoforms differentially regulate Alzheimer-like TAU missorting and Aβ-mediated synapse pathology , 2022, Neural regeneration research.
[2] Bin Yu,et al. Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system , 2022, Experimental Neurology.
[3] S. Silvestre,et al. Role of Aducanumab in the Treatment of Alzheimer’s Disease: Challenges and Opportunities , 2022, Clinical interventions in aging.
[4] Xuezhong Li,et al. Level of LncRNA GAS5 and Hippocampal Volume are Associated with the Progression of Alzheimer’s Disease , 2022, Clinical interventions in aging.
[5] Xingchun Gou,et al. Amyloid-beta targeted therapeutic approaches for Alzheimer's disease: long road ahead. , 2022, Current drug targets.
[6] Rekha S. Patel,et al. Long Noncoding RNA GAS5 Contained in Exosomes Derived from Human Adipose Stem Cells Promotes Repair and Modulates Inflammation in a Chronic Dermal Wound Healing Model , 2022, Biology.
[7] F. D. De Felice,et al. Impaired insulin signalling and allostatic load in Alzheimer disease , 2022, Nature Reviews Neuroscience.
[8] M. Voso,et al. Increased Plasma Levels of lncRNAs LINC01268, GAS5 and MALAT1 Correlate with Negative Prognostic Factors in Myelofibrosis , 2021, Cancers.
[9] R. Dahlstrom,et al. Challenges and opportunities , 2021, Foundations of a Sustainable Economy.
[10] Yisheng Wang,et al. RETRACTED ARTICLE: GAS5 knockdown alleviates spinal cord injury by reducing VAV1 expression via RNA binding protein CELF2 , 2021, Scientific Reports.
[11] Nadezhda T. Doncheva,et al. The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets , 2020, Nucleic Acids Res..
[12] D. Bennett,et al. Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia , 2021, PLoS genetics.
[13] Xiaochuan Sun,et al. Estrogen improved the regeneration of axons after subcortical axon injury via regulation of PI3K/Akt/CDK5/Tau pathway , 2020, Brain and behavior.
[14] F. Wang,et al. Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice , 2020, Brain and behavior.
[15] L. Lipovich,et al. The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers , 2019, Non-coding RNA.
[16] M. Bagherzadeh,et al. A Perspective to the Correlation Between Brain Insulin Resistance and Alzheimer: Medicinal Chemistry Approach. , 2019, Current diabetes reviews.
[17] Vahideh Hassan-Zadeh,et al. The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis , 2019, Clinical Rheumatology.
[18] B. Fiebich,et al. Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration , 2019, International journal of molecular sciences.
[19] N. Patel,et al. Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes. , 2019, Cell chemical biology.
[20] Y. Sun,et al. High expression of GAS5 promotes neuronal death after cerebral infarction by regulating miR-365a-3p. , 2018, European review for medical and pharmacological sciences.
[21] Xiaoting Li,et al. LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway. , 2018, Biochemical and biophysical research communications.
[22] M. Delgado-Rodríguez,et al. Systematic review and meta-analysis. , 2017, Medicina intensiva.
[23] Boyle,et al. Repurposing [ , 2018 .
[24] W. Lukiw,et al. Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain , 2017, Front. Immunol..
[25] Dev Mehta,et al. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015 , 2017, Expert opinion on investigational drugs.
[26] J. Mazar,et al. The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis through activation of BRCA1 and p53 in human neuroblastoma , 2016, Oncotarget.
[27] V. Davey,et al. Herbicide Exposure, Vietnam Service, and Hypertension Risk in Army Chemical Corps Veterans , 2016, Journal of occupational and environmental medicine.
[28] T. Kino,et al. Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases , 2016, Hormone and Metabolic Research.
[29] Gwyn T. Williams,et al. Reciprocal regulation of GAS 5 lncRNA levels and mTOR inhibitor action in prostate cancer cells , 2016 .
[30] N. Patel,et al. Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus , 2015, BBA clinical.
[31] H. Malkki. Alzheimer disease: Insulin resistance could be linked to risk of AD via reduced glucose uptake , 2015, Nature Reviews Neurology.
[32] Gwyn T. Williams,et al. Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells , 2015, The Prostate.
[33] J. Rinn,et al. Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution , 2015, Genome Biology.
[34] N. El-Sayed,et al. Possible role of resveratrol targeting estradiol and neprilysin pathways in lipopolysaccharide model of Alzheimer disease. , 2015, Advances in experimental medicine and biology.
[35] S. Martelossi,et al. Long noncoding RNA GAS5: a novel marker involved in glucocorticoid response. , 2015, Current molecular medicine.
[36] C. Qin,et al. The miR-545/374a Cluster Encoded in the Ftx lncRNA is Overexpressed in HBV-Related Hepatocellular Carcinoma and Promotes Tumorigenesis and Tumor Progression , 2014, PloS one.
[37] M. Schuler,et al. Prognostic Impact of Bcl-2 Depends on Tumor Histology and Expression of MALAT-1 lncRNA in Non–Small-Cell Lung Cancer , 2014, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[38] Qin Chen,et al. lncRNA H19/miR‐675 axis represses prostate cancer metastasis by targeting TGFBI , 2014, The FEBS journal.
[39] P. Moreira,et al. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia , 2014, Front. Endocrinol..
[40] S. Ferreira,et al. Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease , 2014, Diabetes.
[41] S. Arnold,et al. Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease , 2014, Diabetes.
[42] R. Stahel,et al. GAS5 long non-coding RNA in malignant pleural mesothelioma , 2014, Molecular Cancer.
[43] Jie Yao,et al. LncRNA TSLC1-AS1 is a novel tumor suppressor in glioma. , 2014, International journal of clinical and experimental pathology.
[44] C. DeCarli,et al. Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy , 2014, Neurology.
[45] Gwyn T. Williams,et al. Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy , 2014, Breast Cancer Research and Treatment.
[46] M. Mourtada-Maarabouni,et al. Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. , 2013, Biochimica et biophysica acta.
[47] N. Akimitsu,et al. The RNA Degradation Pathway Regulates the Function of GAS5 a Non-Coding RNA in Mammalian Cells , 2013, PloS one.
[48] R. L. Allison. The long road ahead. , 2013, South Dakota medicine : the journal of the South Dakota State Medical Association.
[49] S. Craft. Alzheimer disease: Insulin resistance and AD—extending the translational path , 2012, Nature Reviews Neurology.
[50] P. Bickford,et al. Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform* , 2012, The Journal of Biological Chemistry.
[51] K. Nakashima,et al. [The Rotterdam study]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.
[52] R. Morishita,et al. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. , 2011, Current aging science.
[53] R. Morishita,et al. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. , 2011, Molecular bioSystems.
[54] George Perry,et al. Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease? , 2011, Ageing Research Reviews.
[55] M. Schachner,et al. Expression of the snoRNA host gene gas5 in the hippocampus is upregulated by age and psychogenic stress and correlates with reduced novelty‐induced behavior in C57BL/6 mice , 2010, Hippocampus.
[56] Rajeev Prabhakar,et al. Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study. , 2010, Biochemistry.
[57] Han K. Kang,et al. Mortality patterns of Army Chemical Corps veterans who were occupationally exposed to herbicides in Vietnam. , 2010, Annals of epidemiology.
[58] G. Chrousos,et al. Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor , 2010, Science Signaling.
[59] 松崎 尊信. Insulin resistance is associated with the pathology of Alzheimer's disease : the Hisayama study , 2010 .
[60] R. Castellani,et al. Alzheimer disease. , 2010, Disease-a-month : DM.
[61] I. Grundke‐Iqbal,et al. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. , 2009, The American journal of pathology.
[62] A. Hofman,et al. Insulin metabolism and the risk of Alzheimer's disease: The Rotterdam Study , 2009, Alzheimer's & Dementia.
[63] J. Moriguti,et al. (Pre)diabetes, brain aging, and cognition. , 2009, Biochimica et biophysica acta.
[64] M. Mourtada-Maarabouni,et al. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer , 2009, Oncogene.
[65] H. Kuo,et al. Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis , 2009, PloS one.
[66] V. Haroutunian,et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology , 2008, Neurology.
[67] J. Michalek,et al. Diabetes and Cancer in Veterans of Operation Ranch Hand After Adjustment for Calendar Period, Days of Spraying, and Time Spent in Southeast Asia , 2008, Journal of occupational and environmental medicine.
[68] R. Sidman,et al. TLR8: An Innate Immune Receptor in Brain, Neurons and Axons , 2007, Cell cycle.
[69] Eric M Reiman,et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. , 2007, Physiological genomics.
[70] R. Sidman,et al. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis , 2006, The Journal of cell biology.
[71] P. Riederer,et al. Alzheimer‐like changes in protein kinase B and glycogen synthase kinase‐3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway , 2006, Journal of neurochemistry.
[72] K. Ashe,et al. Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) , 2005, The Journal of Neuroscience.
[73] I. Grundke‐Iqbal,et al. Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations* , 2004, Journal of Biological Chemistry.
[74] D. Bennett,et al. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. , 2004, Archives of neurology.
[75] Paul Pavlidis,et al. Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. , 2004, Learning & memory.
[76] J. Michalek,et al. Serum dioxin and cognitive functioning among veterans of Operation Ranch Hand. , 2001, Neurotoxicology.
[77] L. Philipson,et al. The gas 5 gene shows four alternative splicing patterns without coding for a protein. , 2000, Gene.
[78] J. Steitz,et al. Classification of gas5 as a Multi-Small-Nucleolar-RNA (snoRNA) Host Gene and a Member of the 5′-Terminal Oligopyrimidine Gene Family Reveals Common Features of snoRNA Host Genes , 1998, Molecular and Cellular Biology.
[79] G. Henriksen,et al. Serum Dioxin and Diabetes Mellitus in Veterans of Operation Ranch Hand , 1997, Epidemiology.
[80] Julia M. Goodfellow,et al. Molecular dynamics study , 1997 .
[81] E. Coccia,et al. Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development , 1992 .
[82] E. Coccia,et al. Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. , 1992, Molecular and cellular biology.
[83] S. Katsuki. [Hisayama study]. , 1971, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.
[84] Y. Oshika,et al. P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo. , 1996, British Journal of Cancer.