Molecular mechanisms involved in NAFLD progression
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[1] Raj Vuppalanchi,et al. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management , 2009, Hepatology.
[2] Philippe Giral,et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. , 2008, Gastroenterology.
[3] H. Miller,et al. Safety of Statin Therapy in Patients with Preexisting Liver Disease , 2008, Pharmacotherapy.
[4] M. Permutt,et al. Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis , 2008, Diabetes.
[5] L. N. Valenti,et al. Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis , 2007, Diabetes.
[6] Defeng Wu,et al. Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha–induced liver injury through activation of mitogen‐activated protein kinases in mice , 2008, Hepatology.
[7] M. Nishizawa,et al. Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes. , 2008, Nitric oxide : biology and chemistry.
[8] In-kyu Lee,et al. Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP , 2008, Diabetes.
[9] Kun Wook Chung,et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytess⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of three figures. Published, JLR Papers in Press, October 18, 2007. , 2008, Journal of Lipid Research.
[10] Guoheng Xu,et al. Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-α in Primary Rat Adipocytes , 2008, Molecular Pharmacology.
[11] Y. Hui,et al. Effect of peroxisome proliferator‐activated receptors‐γ and co‐activator‐1α genetic polymorphisms on plasma adiponectin levels and susceptibility of non‐alcoholic fatty liver disease in Chinese people , 2007, Liver international : official journal of the International Association for the Study of the Liver.
[12] José Rodrigo Pauli,et al. Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet. , 2008, Metabolism: clinical and experimental.
[13] J. George,et al. Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. , 2008, Molecular pharmaceutics.
[14] M. Cabana,et al. Probiotic and prebiotic influence beyond the intestinal tract. , 2007, Nutrition reviews.
[15] P. Iynedjian,et al. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. , 2007, Biochemical and biophysical research communications.
[16] B. Neuschwander‐Tetri,et al. The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis , 2007, Hepatology.
[17] K. Cusi,et al. Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis. , 2007, Journal of hepatology.
[18] Y. Chawla,et al. Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions. , 2007, Annals of hepatology.
[19] R. DePinho,et al. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. , 2007, Cell metabolism.
[20] Jongsoon Lee,et al. The role of GSK3 in glucose homeostasis and the development of insulin resistance. , 2007, Diabetes research and clinical practice.
[21] K. Kotoh,et al. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. , 2007, International journal of molecular medicine.
[22] A. Fukamizu,et al. Foxo1 links insulin signaling to C/EBPα and regulates gluconeogenesis during liver development , 2007, The EMBO journal.
[23] N. Cherrington,et al. Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis , 2007, Journal of biochemical and molecular toxicology.
[24] J. Hoofnagle,et al. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis , 2007, Hepatology.
[25] Peter W Angus,et al. Liver fibrosis: a balance of ACEs? , 2007, Clinical science.
[26] E. Distrutti,et al. Targeting farnesoid X receptor for liver and metabolic disorders. , 2007, Trends in molecular medicine.
[27] Jordi Muntané,et al. Mecanismos de lesión hepatocelular , 2007 .
[28] M. Başkol,et al. Oxidative stress and antioxidant defenses in serum of patients with non-alcoholic steatohepatitis. , 2007, Clinical biochemistry.
[29] M. Holmqvist,et al. Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study. , 2007, Journal of hepatology.
[30] Y. Zick,et al. Common Inhibitory Serine Sites Phosphorylated by IRS-1 Kinases, Triggered by Insulin and Inducers of Insulin Resistance* , 2007, Journal of Biological Chemistry.
[31] G. Tarantino,et al. A prospective study of acute drug‐induced liver injury in patients suffering from non‐alcoholic fatty liver disease , 2007, Hepatology research : the official journal of the Japan Society of Hepatology.
[32] S. McCall,et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.
[33] Hui-yu Liu,et al. Prolonged Treatment of Primary Hepatocytes with Oleate Induces Insulin Resistance through p38 Mitogen-activated Protein Kinase* , 2007, Journal of Biological Chemistry.
[34] T. Saibara,et al. The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population. , 2007, Journal of hepatology.
[35] R. Ahima,et al. Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide. , 2007, Gastroenterology.
[36] D. Adams,et al. The Role of Cytokines and Chemokines in the Development of Steatohepatitis , 2007, Seminars in liver disease.
[37] M. C. Archer,et al. Celecoxib Decreases Fatty Acid Synthase Expression via Down-Regulation of c-Jun N-Terminal Kinase-1 , 2007, Experimental biology and medicine.
[38] Hirokazu Takahashi,et al. Telmisartan, An Angiotensin II Type 1 Receptor Blocker, Controls Progress of Nonalcoholic Steatohepatitis in Rats , 2007, Digestive Diseases and Sciences.
[39] R. Ersoy,et al. Effects of vitamin E treatment on peroxisome proliferator‐activated receptor‐α expression and insulin resistance in patients with non‐alcoholic steatohepatitis: results of a pilot study , 2007 .
[40] C. Corporeau,et al. Long-chain n-3 polyunsaturated fatty acids dissociate phosphorylation of Akt from phosphatidylinositol 3'-kinase activity in rats. , 2007, American journal of physiology. Endocrinology and metabolism.
[41] K. Nakao,et al. Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes. , 2007, American journal of physiology. Endocrinology and metabolism.
[42] G. Shulman,et al. Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease , 2007 .
[43] C. McClain,et al. Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. , 2007, The Journal of nutritional biochemistry.
[44] R. Merriman,et al. Medical treatment of non-alcoholic steatohepatitis. , 2007, Clinics in liver disease.
[45] M. Permutt,et al. Inhibition of Foxo1 Protects Pancreatic Islet ® -Cells Against Fatty Acid and ER-Stress Induced Apoptosis , 2007 .
[46] R. Ersoy,et al. Effects of vitamin E treatment on peroxisome proliferator-activated receptor-alpha expression and insulin resistance in patients with non-alcoholic steatohepatitis: results of a pilot study. , 2007, Internal medicine journal.
[47] A. Federico,et al. The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study , 2007, Digestive Diseases and Sciences.
[48] A. Aljada,et al. Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects , 2007, Diabetologia.
[49] M. Wright. The impact of pregnane X receptor activation on liver fibrosis. , 2006, Biochemical Society transactions.
[50] A. Gerbes,et al. Role of Kupffer cells in host defense and liver disease , 2006, Liver international : official journal of the International Association for the Study of the Liver.
[51] A. Diehl,et al. PPARγ Agonists Prevent TGFβ1/Smad3-Signaling in Human Hepatic Stellate Cells , 2006 .
[52] J. Sicklick,et al. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice , 2006, Hepatology.
[53] L. Malaguarnera,et al. Chitotriosidase: the yin and yang , 2006, Cellular and Molecular Life Sciences CMLS.
[54] M. Quon,et al. PKCδ-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function , 2006 .
[55] A. Fukamizu,et al. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. , 2006, The Journal of clinical investigation.
[56] G. Svegliati-Baroni,et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. , 2006, The American journal of pathology.
[57] R. Marco,et al. Potential Role of Chitotriosidase Gene in Nonalcoholic Fatty Liver Disease Evolution , 2006, The American Journal of Gastroenterology.
[58] J. Fernandez-Checa,et al. Mitochondrial glutathione: Hepatocellular survival–death switch , 2006, Journal of gastroenterology and hepatology.
[59] M. Karin,et al. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[60] F. Nicoletti,et al. Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease , 2006, Gut.
[61] G. Shulman,et al. Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action , 2006, Diabetes.
[62] N. Chalasani,et al. Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study. , 2006, The Journal of clinical endocrinology and metabolism.
[63] J. Perkins. Saying “yes” to obese living liver donors: Short‐term intensive treatment for donors with hepatic steatosis in living‐donor liver transplantation. Nakamuta M, Morizono S, Soejiima Y, Yoshizumi T, Aishima S, Takasugi S, et al. Transplantation 2005;80:608–612. , 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
[64] David A. Brenner,et al. Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways , 2006 .
[65] Jawed Alam,et al. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. , 2006, Physiological reviews.
[66] Jeanne M Clark,et al. The Epidemiology of Nonalcoholic Fatty Liver Disease in Adults , 2006, Journal of clinical gastroenterology.
[67] A. McCullough. Pathophysiology of nonalcoholic steatohepatitis. , 2006, Journal of clinical gastroenterology.
[68] Jacqueline Capeau,et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. , 2006, European cytokine network.
[69] T. Okumura,et al. Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. , 2006, Biochemical and biophysical research communications.
[70] C. McClain,et al. Glutathione‐enhancing agents protect against steatohepatitis in a dietary model , 2006, Journal of biochemical and molecular toxicology.
[71] D. Pessayre,et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. , 2006, Mitochondrion.
[72] M. Czaja,et al. Jnk1 but not jnk2 promotes the development of steatohepatitis in mice , 2006, Hepatology.
[73] M. Quon,et al. PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function. , 2006, Biochemical and biophysical research communications.
[74] C. Day. From fat to inflammation. , 2006, Gastroenterology.
[75] R. Schwabe,et al. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. , 2006, American journal of physiology. Gastrointestinal and liver physiology.
[76] P. Portincasa,et al. Current pharmacological treatment of nonalcoholic fatty liver. , 2006, Current medicinal chemistry.
[77] E. Novo,et al. Nrf1 gene expression in the liver: a single gene linking oxidative stress to NAFLD, NASH and hepatic tumours. , 2005, Journal of hepatology.
[78] A. di Sario,et al. Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats. , 2005, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
[79] G. Marchesini,et al. Insulin resistance: A metabolic pathway to chronic liver disease , 2005, Hepatology.
[80] B. Dahiyat,et al. JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes* , 2005, Journal of Biological Chemistry.
[81] B. Sharma,et al. Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH). , 2005, Hepatology research : the official journal of the Japan Society of Hepatology.
[82] C. Kahn,et al. Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. , 2005, Hepatology research : the official journal of the Japan Society of Hepatology.
[83] A. Diehl. Lessons from animal models of NASH. , 2005, Hepatology research : the official journal of the Japan Society of Hepatology.
[84] K. Lindor,et al. Nonalcoholic fatty liver disease , 2005, Canadian Medical Association Journal.
[85] A. Scuto,et al. Action of prolactin, IFN-γ, TNF-α and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages , 2005 .
[86] Shuli Wang,et al. Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD) , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[87] C. De Simone,et al. Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases , 2005, Journal of clinical gastroenterology.
[88] B. Schreiber,et al. PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes , 2005 .
[89] L. N. Valenti,et al. Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes* , 2005, Journal of Biological Chemistry.
[90] A. Scuto,et al. Effect of interferon-γ, interleukin-10, lipopolysaccharide and tumor necrosis factor-α on chitotriosidase synthesis in human macrophages , 2005 .
[91] K. Nakao,et al. [Role of PPARs in the pathophysiology of nonalcoholoic fatty liver disease]. , 2005, Nihon rinsho. Japanese journal of clinical medicine.
[92] M. Malaguarnera,et al. Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. , 2005, Journal of hepatology.
[93] M. Czaja,et al. Hepatocyte CYP2E1 Overexpression and Steatohepatitis Lead to Impaired Hepatic Insulin Signaling* , 2005, Journal of Biological Chemistry.
[94] Candy S. Lee,et al. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[95] E. Ferrannini,et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms , 2005, Diabetologia.
[96] P. Prada,et al. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. , 2005, Endocrinology.
[97] A. Cederbaum,et al. Protein Kinase C Signaling as a Survival Pathway against CYP2E1-Derived Oxidative Stress and Toxicity in HepG2 Cells , 2005, Journal of Pharmacology and Experimental Therapeutics.
[98] G. Rice,et al. Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. , 2005, Endocrinology.
[99] S. Shoelson,et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB , 2005, Nature Medicine.
[100] A. Hevener,et al. IKK-β links inflammation to obesity-induced insulin resistance , 2005, Nature Medicine.
[101] A. Scuto,et al. Action of prolactin, IFN-gamma, TNF-alpha and LPS on heme oxygenase-1 expression and VEGF release in human monocytes/macrophages. , 2005, International immunopharmacology.
[102] A. Scuto,et al. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages. , 2005, Clinical chemistry and laboratory medicine.
[103] K. Kotoh,et al. Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. , 2005, International journal of molecular medicine.
[104] S. Shoelson,et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. , 2005, Nature medicine.
[105] B. Schreiber,et al. PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. , 2005, American journal of physiology. Endocrinology and metabolism.
[106] C. McClain,et al. S‐adenosylhomocysteine sensitizes to TNF‐α hepatotoxicity in mice and liver cells: A possible etiological factor in alcoholic liver disease , 2004, Hepatology.
[107] H. Cortez‐Pinto,et al. Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients , 2004, The American Journal of Gastroenterology.
[108] A. Lonardo,et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver , 2004, Hepatology.
[109] K. Iizuka,et al. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[110] T. Saibara,et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. , 2004, Journal of hepatology.
[111] K. Lindor,et al. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction , 2004, Hepatology.
[112] R. Rodrigo,et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. , 2004, Clinical science.
[113] A. Sonsuz,et al. N‐Acetylcysteine in The Treatment Of Non‐Alcoholic Steatohepatitis , 2003, Journal of gastroenterology and hepatology.
[114] Jay D. Horton,et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[115] Seungho Wang,et al. Temporal and spatial assembly of lipid droplet-associated proteins in 3T3-L1 preadipocytes , 2003, Histochemistry and Cell Biology.
[116] M. Reitman,et al. Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass* , 2003, Journal of Biological Chemistry.
[117] R. Potter,et al. The heme oxygenase system: its role in liver inflammation. , 2003, Current drug targets. Cardiovascular & haematological disorders.
[118] S. Wakil,et al. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[119] M. Koruk,et al. Serum Lipids, Lipoproteins and Apolipoproteins Levels in Patients With Nonalcoholic Steatohepatitis , 2003, Journal of clinical gastroenterology.
[120] Z. Dong,et al. Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases* , 2003, Journal of Biological Chemistry.
[121] A. Moser,et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease , 2003, Hepatology.
[122] M. White,et al. c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade* , 2003, The Journal of Biological Chemistry.
[123] Jianping Ye,et al. Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210 , 2002, The Journal of Biological Chemistry.
[124] N. Abraham,et al. Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells. , 2002, International journal of molecular medicine.
[125] Naresh Kumar,et al. Metformin enhances insulin signalling in insulin‐dependent and ‐independent pathways in insulin resistant muscle cells , 2002, British journal of pharmacology.
[126] I. G. Fantus,et al. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-δ , 2002 .
[127] M. White,et al. IRS proteins and the common path to diabetes. , 2002, American journal of physiology. Endocrinology and metabolism.
[128] R. Sears,et al. Insulin Inhibits Hepatocellular Glucose Production by Utilizing Liver-enriched Transcriptional Inhibitory Protein to Disrupt the Association of CREB-binding Protein and RNA Polymerase II with the Phosphoenolpyruvate Carboxykinase Gene Promoter* , 2002, The Journal of Biological Chemistry.
[129] A. Lonardo,et al. Apolipoprotein synthesis in nonalcoholic steatohepatitis , 2002, Hepatology.
[130] M. Weltman,et al. HFE mutations, hepatic iron, and fibrosis: Ethnic‐specific association of NASH with C282Y but not with fibrotic severity , 2002, Hepatology.
[131] Joseph L Goldstein,et al. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. , 2002, The Journal of clinical investigation.
[132] H. Yamashita,et al. Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription , 2002, The Journal of Biological Chemistry.
[133] R. Karim,et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome , 2002, Hepatology.
[134] I. G. Fantus,et al. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. , 2002, American journal of physiology. Endocrinology and metabolism.
[135] J. Maher. Alcoholic steatosis and steatohepatitis. , 2002, Seminars in gastrointestinal disease.
[136] Jianping Ye,et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. , 2002, The Journal of biological chemistry.
[137] C. Kahn,et al. Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.
[138] I. Leclercq,et al. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[139] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[140] G. Sesti,et al. Defects of the insulin receptor substrate (IRS) system in human metabolic disorders , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[141] M. Sakurai,et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[142] Shelly C. Lu,et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[143] J. Clore,et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. , 2001, Gastroenterology.
[144] Martin M. Matzuk,et al. Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2 , 2001, Science.
[145] M. Cheung,et al. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. , 2001, Journal of lipid research.
[146] B. Jude,et al. PPARα Agonists Inhibit Tissue Factor Expression in Human Monocytes and Macrophages , 2001 .
[147] R. Rozen,et al. Polymorphisms in the Methylenetetrahydrofolate Reductase Gene , 2001, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.
[148] J. Reddy,et al. Peroxisomal β-Oxidation and Steatohepatitis , 2001 .
[149] E. Brunt. Nonalcoholic Steatohepatitis: Definition and Pathology , 2001, Seminars in liver disease.
[150] R. Rozen,et al. Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. , 2001, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.
[151] M. Rao,et al. Peroxisomal beta-oxidation and steatohepatitis. , 2001, Seminars in liver disease.
[152] D. Pessayre,et al. Mitochondria in Steatohepatitis , 2001, Seminars in liver disease.
[153] G. Marchesini,et al. Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis. , 2000, Metabolism: clinical and experimental.
[154] M. Tirmenstein,et al. Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions. , 2000, Chemico-biological interactions.
[155] Z. Halpern,et al. NASH: Can we iron out the pathogenesis? , 2000, Gastroenterology.
[156] I. Leclercq,et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. , 2000, The Journal of clinical investigation.
[157] M. Kasuga,et al. Role of SNAP23 in Insulin-induced Translocation of GLUT4 in 3T3-L1 Adipocytes , 2000, The Journal of Biological Chemistry.
[158] S. Chirala,et al. The subcellular localization of acetyl-CoA carboxylase 2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[159] G. Shulman,et al. On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .
[160] M. Suematsu,et al. The heme oxygenase–carbon monoxide system: u regulator of hepatobiliary function , 2000, Hepatology.
[161] Jay D. Horton,et al. Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus* , 1999, The Journal of Biological Chemistry.
[162] B. Spiegelman,et al. Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism , 1999, Molecular and Cellular Biology.
[163] G. Serrero,et al. Adipose Differentiation Related Protein (ADRP) Expressed in Transfected COS-7 Cells Selectively Stimulates Long Chain Fatty Acid Uptake* , 1999, The Journal of Biological Chemistry.
[164] F. Folli,et al. Insulin and insulin‐like growth factor‐1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways , 1999, Hepatology.
[165] J. Björkegren,et al. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. , 1999, The Journal of clinical investigation.
[166] C. Kahn,et al. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. , 1999, The Journal of clinical investigation.
[167] C. D. de Vries,et al. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. , 1999, Arteriosclerosis, thrombosis, and vascular biology.
[168] V. P. Chacko,et al. Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion* , 1999, The Journal of Biological Chemistry.
[169] L. Olson,et al. Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization , 1998, Mammalian Genome.
[170] D. Accili,et al. Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes* , 1998, The Journal of Biological Chemistry.
[171] C. Fan,et al. Steatohepatitis, Spontaneous Peroxisome Proliferation and Liver Tumors in Mice Lacking Peroxisomal Fatty Acyl-CoA Oxidase , 1998, The Journal of Biological Chemistry.
[172] W. Fiers,et al. Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines. , 1998, Journal of lipid research.
[173] B. Spiegelman,et al. ADD1/SREBP1 activates PPARγ through the production of endogenous ligand , 1998 .
[174] M. Ingelman-Sundberg,et al. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis , 1998, Hepatology.
[175] B. Spiegelman,et al. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[176] N. Kaplowitz,et al. Mitochondrial glutathione: importance and transport. , 1998, Seminars in liver disease.
[177] F. Corrales,et al. Interaction of liver methionine adenosyltransferase with hydroxyl radical , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[178] G. Poli,et al. The lipid peroxidation end product 4‐hydroxy‐2,3‐nonenal up‐regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis 1 , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[179] J. Goldstein,et al. The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.
[180] M. C. Ellis,et al. A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis , 1996, Nature Genetics.
[181] A. Varki,et al. Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[182] C. Trautwein,et al. Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis? , 1994, Hepatology.
[183] W. Fiers,et al. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. , 1992, The Journal of biological chemistry.
[184] S. Friedman. Cellular Sources of Collagen and Regulation of Collagen Production in Liver , 1990, Seminars in liver disease.
[185] M. Maines. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[186] J. Mato,et al. S‐adenosyl‐L‐methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis , 1988, Hepatology.
[187] F. Schaffner,et al. Nonalcoholic fatty liver disease. , 1986, Progress in liver diseases.