Receptor activator of nuclear ??B ligand and osteoprotegerin: where are we now and what about future treatment uses?
暂无分享,去创建一个
E. Schwarz | R. O’Keefe | L. Xing | C. Ritchlin | R. Looney | Regis J O Keefe | R. Looney
[1] Colin R Dunstan,et al. A Single‐Dose Placebo‐Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[2] P. Cohen. Self-arthrocentesis in a man with joint pain. , 2004, Arthritis and rheumatism.
[3] E. Schwarz,et al. RANK Signaling Is Not Required for TNFα‐Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα‐Mediated Inflammatory Arthritis , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[4] L. Frommelt,et al. Receptor activator of nuclear factor κB ligand is expressed in resident and inflammatory cells in aseptic and septic prosthesis loosening , 2003, Scandinavian journal of rheumatology.
[5] Mary L Bouxsein,et al. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. , 2003, The New England journal of medicine.
[6] David L. Lacey,et al. Osteoclast differentiation and activation , 2003, Nature.
[7] E. Schwarz,et al. Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. , 2003, The Journal of clinical investigation.
[8] J. Risteli,et al. Two year randomized controlled trial of etidronate in rheumatoid arthritis: changes in serum aminoterminal telopeptides correlate with radiographic progression of disease. , 2003, The Journal of rheumatology.
[9] Steven W. Martin,et al. A Phase I study of AMGN‐0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases , 2003, Cancer.
[10] E. Schwarz,et al. Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone , 2003 .
[11] L. Joosten,et al. Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. , 2002, Arthritis and rheumatism.
[12] T. Martin,et al. Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. , 2002, The American journal of pathology.
[13] Kirk E. Smith,et al. Recombinant Adeno-Associated Virus-Mediated Osteoprotegerin Gene Therapy Inhibits Wear Debris-Induced Osteolysis , 2002, The Journal of bone and joint surgery. American volume.
[14] G. Kollias,et al. Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. , 2002, Arthritis and rheumatism.
[15] E. Schwarz,et al. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
[16] Y. Iwamoto,et al. Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells , 2002, Annals of the rheumatic diseases.
[17] A. Boskey,et al. In Vivo RANK Signaling Blockade Using the Receptor Activator of NF‐κB:Fc Effectively Prevents and Ameliorates Wear Debris‐Induced Osteolysis via Osteoclast Depletion Without Inhibiting Osteogenesis , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[18] A R Pettit,et al. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. , 2001, The American journal of pathology.
[19] P. Kostenuik,et al. Printed in U.S.A. Copyright © 2001 by The Endocrine Society OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats , 2022 .
[20] D. Howie,et al. The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis. , 2001, The Journal of bone and joint surgery. British volume.
[21] P. Kostenuik,et al. Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. , 2001, Cancer research.
[22] A. Mizokami,et al. Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. , 2001, The Journal of clinical investigation.
[23] Paul J. Williams,et al. Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. , 2001, Cancer research.
[24] A. Nakanishi,et al. The Effect of a Single Dose of Osteoprotegerin in Postmenopausal Women , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[25] S. Takeshita,et al. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. , 2000, The Journal of clinical investigation.
[26] E. Schwarz,et al. Breakthrough in bone: the molecular mechanism of osteoclast/osteoblast coupling revealed , 2000 .
[27] S. Teitelbaum,et al. Bone resorption by osteoclasts. , 2000, Science.
[28] T. Martin,et al. Expression of osteoclast differentiation factor at sites of bone erosion in collagen-induced arthritis. , 2000, Arthritis and rheumatism.
[29] P. Kostenuik,et al. Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. , 2000, Cancer research.
[30] Kozo Nakamura,et al. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[31] S. Goldring,et al. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. , 2000, Arthritis and rheumatism.
[32] Sundeep Khosla,et al. The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[33] Josef M. Penninger,et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand , 1999, Nature.
[34] W. Dougall,et al. RANK is essential for osteoclast and lymph node development. , 1999, Genes & development.
[35] S. Morony,et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis , 1999, Nature.
[36] S. Morony,et al. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. , 1998, Genes & development.
[37] D. Lacey,et al. Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation , 1998, Cell.
[38] R. Dubose,et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function , 1997, Nature.
[39] H. Rubash,et al. The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. , 1997, Clinical orthopaedics and related research.
[40] G Shimamoto,et al. Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density , 1997, Cell.
[41] W. Harris,et al. The problem is osteolysis. , 1995, Clinical orthopaedics and related research.
[42] S. Ralston,et al. Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis. , 1989, Annals of the rheumatic diseases.
[43] E. Schwarz,et al. Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice , 2004 .