Slow transitions and hysteretic behavior in enzymes.

PERSPECTIVES AND SUMMARY . INTRODUCTION . SOME TIME RANGES FOR DIFFERENT PROCESSES . . SOME PROPOSED MECHANISMS FOR HYSTERETIC BEHAVIOR . . Monomeric Enzymes . �%{yc:n�:rn:E!'; ;;,:i;:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: Ligand Off Rates . ANALYSIS OF HYSTERETIC BEHAVIOR .. Evaluation o[ k . The Use o[ the Full Time Course o[ the Reaction .. The Effect o[ Ligand or Substrate Concentratioll all k . . Variatioll o[ V I and vf with Substrate Concentration: Lags or Bursts .. CONCLUSIONS .