The effects of long-term ovariectomy and estrogen replacement therapy on learning and memory in monkeys (Macaca fascicularis).

This study determined the effects of estrogen loss and replacement therapy on learning and memory function in monkeys (Macaca fascicularis). The ability to learn, remember, and perform reversals of object discriminations and the accuracy on a spatial delayed response task were found to be comparable in young adult surgically menopausal monkeys receiving estrogen or placebo treatment for 5 or 16 months. Learning and memory abilities were comparable with baseline values following 2, 12, or 24 months of ovariectomy in monkeys. Pre- and postoperative injections of scopolamine in a subset of monkeys revealed only subtle increases in sensitivity on the delayed response task following ovariectomy. These observations in surgically menopausal monkeys have some parallels with those made in surgically menopausal women and suggest that, in the absence of other confounding factors, certain aspects of learning and memory may not be influenced by estrogen in primates.

[1]  R. Gibbs.  Estrogen Replacement Enhances Acquisition of a Spatial Memory Task and Reduces Deficits Associated with Hippocampal Muscarinic Receptor Inhibition , 1999, Hormones and Behavior.

[2]  V. Denenberg,et al.  Estradiol facilitates performance as working memory load increases , 1999, Psychoneuroendocrinology.

[3]  K. Beck,et al.  Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters , 1998, Hormones and Behavior.

[4]  R. Gibbs.  Impairment of Basal Forebrain Cholinergic Neurons Associated with Aging and Long-Term Loss of Ovarian Function , 1998, Experimental Neurology.

[5]  G. Dohanich,et al.  Estrogen Improves Performance of Reinforced T-Maze Alternation and Prevents the Amnestic Effects of Scopolamine Administered Systemically or Intrahippocampally , 1998, Neurobiology of Learning and Memory.

[6]  K. Yaffe,et al.  Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. , 1998, JAMA.

[7]  H Helenius,et al.  The Effect of Short‐Term Estrogen Replacement Therapy on Cognition: A Randomized, Double‐Blind, Cross‐Over Trial in Postmenopausal Women , 1998, Obstetrics and gynecology.

[8]  S. Resnick,et al.  Estrogen replacement therapy and longitudinal decline in visual memory , 1997, Neurology.

[9]  M. Rice,et al.  Estrogen replacement therapy and cognitive function in postmenopausal women without dementia. , 1997, The American journal of medicine.

[10]  M. Packard,et al.  Posttraining Estradiol Injections Enhance Memory in Ovariectomized Rats: Cholinergic Blockade and Synergism , 1997, Neurobiology of Learning and Memory.

[11]  P. Rapp,et al.  Reproductive senescence predicts cognitive decline in aged female monkeys , 1997, Neuroreport.

[12]  C. Singer,et al.  The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague-Dawley rat , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  P S Goldman-Rakic,et al.  Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[14]  L. Means,et al.  Estrogen affects performance of ovariectomized rats in a two-choice water-escape working memory task , 1996, Psychoneuroendocrinology.

[15]  F. Gengo,et al.  Possible acceleration of age effects on cognition following menopause. , 1995, Journal of psychiatric research.

[16]  V. Luine,et al.  Effects of estradiol on radial arm maze performance of young and aged rats. , 1994, Behavioral and neural biology.

[17]  R. Gibbs.  Estrogen and Nerve Growth Factor‐related Systems in Brain , 1994, Annals of the New York Academy of Sciences.

[18]  B. Sherwin.  Estrogenic Effects on Memory in Women a , 1994, Annals of the New York Academy of Sciences.

[19]  G. Dohanich,et al.  Estrogen and estrogen-progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats. , 1994, Behavioral neuroscience.

[20]  N. Hagino,et al.  Evaluation of estrogen treatment in female patients with dementia of the Alzheimer type. , 1994, Endocrine journal.

[21]  B. Sherwin,et al.  Estrogen Use and Verbal Memory in Healthy Postmenopausal Women , 1994, Obstetrics and gynecology.

[22]  W. Millard,et al.  Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats , 1994, Brain Research.

[23]  A. Oldenhave,et al.  Pathogenesis of climacteric complaints: ready for the change? , 1994, The Lancet.

[24]  ML Voytko,et al.  Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents] , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  A. Arnsten,et al.  Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine , 1993, Neurobiology of Aging.

[26]  M. Voytko.  Cognitive changes during normal aging in monkeys assessed with an automated test apparatus , 1993, Neurobiology of Aging.

[27]  E. Barrett-Connor,et al.  Estrogen replacement therapy and cognitive function in older women. , 1993, JAMA.

[28]  B. Sherwin,et al.  Effects of estrogen on memory function in surgically menopausal women , 1992, Psychoneuroendocrinology.

[29]  S. Manuck,et al.  Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. , 1990, Arteriosclerosis.

[30]  S. E. Rankin,et al.  Effects on bone of surgical menopause and estrogen therapy with or without progesterone replacement in cynomolgus monkeys. , 1990, American journal of obstetrics and gynecology.

[31]  B. Sherwin,et al.  Estrogen and Cognitive Functioning in Surgically Menopausal Women a , 1990 .

[32]  B. Sherwin,et al.  Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women , 1988, Psychoneuroendocrinology.

[33]  L. Fitten,et al.  Oral tacrine administration in middle-aged monkeys: Effects on discrimination learning , 1988, Neurobiology of Aging.

[34]  T. Hassard,et al.  Researching the symptoms of menopause: an exercise in methodology. , 1988, Maturitas.

[35]  C. A. O'Malley,et al.  Effects of ovariectomy and estradiol benzoate on high affinity choline uptake, ACh synthesis, and release from rat cerebral cortical synaptosomes , 1987, Brain Research.

[36]  S. Hamburger,et al.  Characteristics of menopausal women seeking assistance. , 1987 .

[37]  H. Fillit,et al.  Observations in a preliminary open trial of estradiol therapy for senile dementia-alzheimer's type , 1986, Psychoneuroendocrinology.

[38]  C. FernándezdelCastilloS.  Gynecology and Obstetrics , 1986 .

[39]  M. Voytko.  Visual learning and retention examined with reversible cold lesions of the anterior temporal lobe , 1986, Behavioural Brain Research.

[40]  M. Voytko.  Cooling orbital frontal cortex disrupts matching-to-sample and visual discrimination learning in monkeys , 1985 .

[41]  L. C. Miller,et al.  Bone measurement by enhanced contrast image analysis: ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis. , 1985, American journal of physical anthropology.

[42]  T. Clarkson,et al.  Ovariectomy, Social Status, and Atherosclerosis in Cynomolgus Monkeys , 1985, Arteriosclerosis.

[43]  L. Squire,et al.  Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia. , 1985, Behavioral neuroscience.

[44]  M. Schiffer,et al.  CONTRACTION STRESS TEST BY BREAST STIMULATION AS PART OF ANTEPARTUM MONITORING , 1985, Acta obstetricia et gynecologica Scandinavica.

[45]  M. Mishkin.  A memory system in the monkey. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[46]  H. E. Rosvold,et al.  Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. , 1979, Science.

[47]  A. L. Goodman,et al.  Composite Pattern of Circulating LH, FSH, Estradiol, and Progesterone during the Menstrual Cycle in Cynomolgus Monkeys , 1977, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[48]  P. Fedor-Freybergh.  THE INFLUENCE OF OESTROGENS ON THE WELLBEING AND MENTAL PERFORMANCE IN CLIMACTERIC AND POSTMENOPAUSAL WOMEN , 1977, Acta obstetricia et gynecologica Scandinavica. Supplement.

[49]  W. Collins,et al.  Hormonal profiles after the menopause. , 1976, British medical journal.

[50]  R. Bartus,et al.  Short-term memory in the rhesus monkey: Disruption from the anti-cholinergic scopolamine , 1976, Pharmacology Biochemistry and Behavior.

[51]  H. Kopera.  Estrogens and Psychic Functions , 1973 .

[52]  H. E. Rosvold,et al.  Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. , 1970, Experimental neurology.

[53]  J. Biehl,et al.  Effect of Isoniazid on Vitamin B6 Metabolism; Its Possible Significance in Producing Isoniazid Neuritis.∗ , 1954, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[54]  B. Caldwell.  An evaluation of psychological effects of sex hormone administration in aged women. II. Results of therapy after eighteen months. , 1952, Journal of gerontology.

[55]  HighWire Press.  Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[56]  Nambara Toshio,et al.  In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type). , 1989 .

[57]  B. Hackman,et al.  Replacement therapy and piperazine oestrone sulphate ('Harmogen') and its effect on memory. , 1976, Current medical research and opinion.

[58]  R. Punnonen,et al.  The effect of castration and peroral estrogen therapy on some psychological functions. , 1975, Frontiers of hormone research.