Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study

Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.

[1]  R. Eeles,et al.  A Review of Prostate Cancer Genome-Wide Association Studies (GWAS) , 2018, Cancer Epidemiology, Biomarkers & Prevention.

[2]  M. Kogevinas,et al.  Mediterranean Dietary Pattern is Associated with Low Risk of Aggressive Prostate Cancer: MCC‐Spain Study , 2018, The Journal of urology.

[3]  L. Rink,et al.  Zinc as a Gatekeeper of Immune Function , 2017, Nutrients.

[4]  V. Moreno,et al.  Risk Model for Prostate Cancer Using Environmental and Genetic Factors in the Spanish Multi-Case-Control (MCC) Study , 2017, Scientific Reports.

[5]  L. Serra-Majem,et al.  Reported Dietary Intake and Food Sources of Zinc, Selenium, and Vitamins A, E and C in the Spanish Population: Findings from the ANIBES Study † , 2017, Nutrients.

[6]  J. McKenney,et al.  Prostate cancer – major changes in the American Joint Committee on Cancer eighth edition cancer staging manual , 2017, CA: a cancer journal for clinicians.

[7]  J. King,et al.  A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations123 , 2016, The American journal of clinical nutrition.

[8]  R. Franklin,et al.  A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer. , 2016, Archives of biochemistry and biophysics.

[9]  R. Kittles,et al.  Zinc Intake and Risk of Prostate Cancer: Case-Control Study and Meta-Analysis , 2016, PLoS ONE.

[10]  B. Delahunt,et al.  The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System , 2015, The American journal of surgical pathology.

[11]  Vicente Martín,et al.  Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design. , 2015, Gaceta sanitaria.

[12]  L. Moreno,et al.  Factors that affect zinc bioavailability and losses in adult and elderly populations. , 2014, Nutrition reviews.

[13]  M. Hediger,et al.  Zinc transporters in prostate cancer. , 2013, Molecular aspects of medicine.

[14]  J. Ferlay,et al.  Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. , 2013, European journal of cancer.

[15]  L. Serra-Majem,et al.  The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network , 2012, British Journal of Nutrition.

[16]  R. Gibson.  A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status. , 2012, Advances in nutrition.

[17]  J. Marshall.  Diet and prostate cancer prevention , 2012, World Journal of Urology.

[18]  A. Wolk,et al.  Dietary zinc and prostate cancer survival in a Swedish cohort. , 2011, The American journal of clinical nutrition.

[19]  O. Bagasra,et al.  Differential zinc accumulation and expression of human zinc transporter 1 (hZIP1) in prostate glands. , 2010, Methods.

[20]  E. Fridman,et al.  New prospective for non‐invasive detection, grading, size evaluation, and tumor location of prostate cancer , 2010, The Prostate.

[21]  I. Thompson,et al.  American Journal of Epidemiology Original Contribution Diet, Supplement Use, and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial , 2022 .

[22]  N. Krebs,et al.  Zinc bioavailability and homeostasis. , 2010, The American journal of clinical nutrition.

[23]  V. Adhami,et al.  Dietary zinc and prostate cancer in the TRAMP mouse model. , 2010, Journal of medicinal food.

[24]  L. Serra-Majem,et al.  Dietary assessment methods for intakes of iron, calcium, selenium, zinc and iodine , 2009, British Journal of Nutrition.

[25]  Gert B. M. Mensink,et al.  Intake of selected nutrients from foods, from fortification and from supplements in various European countries , 2009, Food & nutrition research.

[26]  F. Grases,et al.  Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. , 2009, Molecular nutrition & food research.

[27]  J. Palmer,et al.  Vitamin and mineral use and risk of prostate cancer: the case–control surveillance study , 2009, Cancer Causes & Control.

[28]  U. Peters,et al.  Zinc Intake From Supplements and Diet and Prostate Cancer , 2009, Nutrition and cancer.

[29]  McGraw-Hill. Interamericana,et al.  TABLAS DE COMPOSICIÓN DE ALIMENTOS DEL CESNID , 2008 .

[30]  C. la Vecchia,et al.  Dietary zinc and prostate cancer risk: a case-control study from Italy. , 2007, European urology.

[31]  A. Wolk.  Editorial comment on: Dietary zinc and prostate cancer risk: a case-control study from Italy. , 2007, European urology.

[32]  R. Franklin,et al.  Zinc as an anti-tumor agent in prostate cancer and in other cancers. , 2007, Archives of biochemistry and biophysics.

[33]  R. Franklin,et al.  The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots , 2006, Molecular Cancer.

[34]  D. Altshuler,et al.  Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort. , 2006, Journal of the National Cancer Institute.

[35]  O. Bagasra,et al.  Zinc and Prostate Cancer: A Critical Scientific, Medical, and Public Interest Issue (United States) , 2005, Cancer Causes & Control.

[36]  O. Bagasra,et al.  hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer , 2005, Molecular Cancer.

[37]  P. Galan,et al.  Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial , 2005, International journal of cancer.

[38]  Matthias Egger,et al.  Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis , 2004, The Lancet.

[39]  C. Krone,et al.  Re: Zinc supplement use and risk of prostate cancer. , 2003, Journal of the National Cancer Institute.

[40]  W. Willett,et al.  Zinc supplement use and risk of prostate cancer. , 2003, Journal of the National Cancer Institute.

[41]  J. Epstein,et al.  Gleason score 2-4 adenocarcinoma of the prostate on needle biopsy: a diagnosis that should not be made. , 2000, The American journal of surgical pathology.

[42]  Y. Kondo,et al.  Modulation of telomerase activity by zinc in human prostatic and renal cancer cells. , 2000, Biochemical pharmacology.

[43]  関澤 純,et al.  IPCS (International Programme on Chemical Safety : 国際化学物質安全性計画) , 1999 .

[44]  J. Stanford,et al.  Vitamin and mineral supplement use is associated with reduced risk of prostate cancer. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[45]  M. Spitz,et al.  Case-control study of diet and prostate cancer in China , 1998, Cancer Causes & Control.

[46]  H. Adami,et al.  Energy, nutrient intake and prostate cancer risk: a population‐based case‐control study in Sweden , 1996, International journal of cancer.

[47]  W. Willett,et al.  Development and validation of a food frequency questionnaire in Spain. , 1993, International journal of epidemiology.

[48]  T. French,et al.  Adult dietary intake and prostate cancer risk in Utah: a case-control study with special emphasis on aggressive tumors , 1991, Cancer Causes & Control.

[49]  J. Hankin,et al.  Diet and prostatic cancer: a case-control study in Hawaii. , 1988, American journal of epidemiology.

[50]  R. Chandra.  Excessive intake of zinc impairs immune responses. , 1984, JAMA.

[51]  J. King,et al.  Biomarkers of Nutrition for Development (BOND)-Zinc Review. , 2016, The Journal of nutrition.

[52]  H. Sandstead.  Chapter 61 – Zinc , 2015 .

[53]  R. Franklin,et al.  Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer. , 2005, Frontiers in bioscience : a journal and virtual library.

[54]  M. Tan,et al.  Role of zinc in the pathogenesis and treatment of prostate cancer: critical issues to resolve , 2004, Prostate Cancer and Prostatic Diseases.

[55]  W. Willett,et al.  Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[56]  D. Bishop,et al.  A case-control study of diet and prostate cancer. , 1997, British Journal of Cancer.

[57]  D. S. Coffey,et al.  Telomerase activity: a prevalent marker of malignant human prostate tissue. , 1996, Cancer research.

[58]  K. Shadan,et al.  Available online: , 2012 .

[59]  Robert M. Russell,et al.  Dietary Reference Intakes for Vitamin A , Vitamin K , Arsenic , Boron , Chromium , Copper , Iodine , Iron , Manganese , Molybdenum , Nickel , Silver , Vanadium , and Zinc , 2022 .