Is research on hormones and aging finished? No! Just started!

Levels of many hormones differ between older and younger persons. This has led to a popular hypothesis that these testing differences are “abnormal” in older people and therefore should be corrected (1–5). Beyond the research community, prescriptions of anabolic hormones such as growth hormone and testosterone have skyrocketed. However, whether these endocrine changes represent “normal aging” or progressive glandular disease, and whether there would be benefit to their correction is currently unresolved.

[1]  S. Bandinelli,et al.  Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. , 2007, Archives of internal medicine.

[2]  Federico Licastro,et al.  Endogenous sex hormones as risk factors for dementia in elderly men and women. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  I. Olkin,et al.  Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy Elderly , 2007, Annals of Internal Medicine.

[4]  P. Ponikowski,et al.  Anabolic Deficiency in Men With Chronic Heart Failure: Prevalence and Detrimental Impact on Survival , 2006, Circulation.

[5]  Claudio Cobelli,et al.  DHEA in elderly women and DHEA or testosterone in elderly men. , 2006, The New England journal of medicine.

[6]  L. Ferrucci,et al.  DHEAS levels and mortality in disabled older women: the Women's Health and Aging Study I. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[7]  L. Ferrucci,et al.  Phenotype of frailty: characterization in the women's health and aging studies. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[8]  J. Manson,et al.  Postmenopausal hormone therapy: new questions and the case for new clinical trials , 2006, Menopause.

[9]  T. Rantanen,et al.  Endogenous hormones, muscle strength, and risk of fall-related fractures in older women. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  Martin L. Lee,et al.  Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  L. Baum.  Sex, hormones, and Alzheimer's disease. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[12]  W. Aronow,et al.  Use of hormone replacement therapy by postmenopausal women after publication of the Women's Health Initiative Trial. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  Stephanie J. Fonda,et al.  Age, hormones, and cognitive functioning among middle-aged and elderly men: cross-sectional evidence from the Massachusetts Male Aging Study. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[14]  S. Bandinelli,et al.  The relationship between testosterone and molecular markers of inflammation in older men. , 2005, Journal of endocrinological investigation.

[15]  Y. Iwasaki,et al.  Dehydroepiandrosterone-sulfate inhibits nuclear factor-kappaB-dependent transcription in hepatocytes, possibly through antioxidant effect. , 2004, The Journal of clinical endocrinology and metabolism.

[16]  T. Perls.  Anti-aging quackery: human growth hormone and tricks of the trade--more dangerous than ever. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[17]  John Robbins,et al.  National cross sectional survey to determine whether the decision to delivery interval is critical in emergency caesarean section , 2004, BMJ : British Medical Journal.

[18]  D. Blazer,et al.  Testosterone and aging : clinical research directions , 2004 .

[19]  L. Ferrucci,et al.  Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. , 2003, The Journal of clinical endocrinology and metabolism.

[20]  C. Lang,et al.  Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. , 2003, Minerva endocrinologica.

[21]  H. Perry,et al.  Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. , 1997, Proceedings of the National Academy of Sciences of the United States of America.