High Resolution Regional Elasticity Mapping of the Human Prostate

What is it that the clinician "feels" during a digital rectal examination? To answer this question, it is necessary to measure the elastic properties of the prostate and verify the stiffness values with histological examination. Therefore, we devised an Elasticity Mapping System to evaluate the elastic properties of various histopathological grades of prostate cancer in relation to benign prostatic hyperplasia (BPH) and normal tissue. The system consists of a micro tactile sensor, a three-axis (XYZ) with one (fine Z) micromanipulation stage, a stereoscope camera and a measurement chamber. Using this methodology we mapped the elasticity of human prostate cancer (CaP) and it was obviously observed that the node was significantly harder than surrounding normal tissues and had some textures.

[1]  Sadao Omata,et al.  Fabrication of micro tactile sensor for the measurement of micro-scale local elasticity , 2004 .

[2]  Sadao Omata,et al.  New tactile sensor like the human hand and its applications , 1992 .

[3]  Christos E. Constantinou,et al.  Analysis of the relative biomechanical effects of α1 and α2 antagonists in modifying the compliance of the prostate and micturition parameters of the hormonally manipulated male rat , 1996 .

[4]  G. Gladwell,et al.  The contact-impedance meter-3 , 1968 .

[5]  S Omata,et al.  Analysis of the relative biomechanical effects of alpha 1 and alpha 2 antagonists in modifying the compliance of the prostate and micturition parameters of the hormonally manipulated male rat. , 1996, Neurourology and urodynamics.

[6]  S. Omata,et al.  Development of Tactile Mapping system for the stiffness characterization of tissue slice using novel tactile sensing technology , 2005 .

[7]  C. Constantinou,et al.  Modeling of micturition characteristics based on prostatic stiffness modulation induced using hormones and adrenergic antagonists , 1995, IEEE Transactions on Biomedical Engineering.

[8]  S Omata,et al.  Chronology and urodynamic characterization of micturition in neurohormonally induced experimental prostate growth in the rat , 1998, Neurourology and urodynamics.

[9]  Y. Murayama,et al.  Considerations in the design and sensitivity optimization of the micro tactile sensor , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[10]  S. Omata,et al.  Micro-mechanical sensing platform for the characterization of the elastic properties of the ovum via uniaxial measurement. , 2004, Journal of biomechanics.