T-cell receptor degeneracy: the dog that did not bark. Adaptation of the self-reactive T-cell response to limit autoimmune disease.

[1]  D. Wraith,et al.  Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo 1 , 2003, The Journal of Immunology.

[2]  Y. Belkaid,et al.  CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity , 2002, Nature.

[3]  M. A. Curotto de Lafaille,et al.  CD4(+) regulatory T cells in autoimmunity and allergy. , 2002, Current opinion in immunology.

[4]  J. Weinstock,et al.  CD4+ TCR Repertoire Heterogeneity in Schistosoma mansoni-Induced Granulomas1 , 2002, The Journal of Immunology.

[5]  G. B. Cohen,et al.  Examination of the highly diverse CD4+ T-cell repertoire directed against an influenza peptide: a step towards TCR proteomics , 2002, Immunogenetics.

[6]  Lindsay B. Nicholson,et al.  Reduced Self-Reactivity of an Autoreactive T Cell After Activation with Cross-reactive Non–Self-Ligand , 2002, The Journal of experimental medicine.

[7]  Mark S. Anderson,et al.  Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein , 2002, Science.

[8]  J. Bach,et al.  The effect of infections on susceptibility to autoimmune and allergic diseases. , 2002, The New England journal of medicine.

[9]  E. Unanue,et al.  Cutting Edge: The Relative Distribution of T Cells Responding to Chemically Dominant or Minor Epitopes of Lysozyme Is Not Affected by CD40-CD40 Ligand and B7-CD28-CTLA-4 Costimulatory Pathways1 , 2002, The Journal of Immunology.

[10]  D. Wraith,et al.  Selection and fine-tuning of the autoimmune T-cell repertoire , 2002, Nature Reviews Immunology.

[11]  E. Unanue,et al.  Cutting Edge: Chemical Dominance Does Not Relate to Immunodominance: Studies of the CD4+ T Cell Response to a Model Antigen , 2002, The Journal of Immunology.

[12]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[13]  F. Powrie,et al.  Regulatory T cells in the control of immune pathology , 2001, Nature Immunology.

[14]  Sayuri Yamazaki,et al.  Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.

[15]  K. Hogquist.  Signal strength in thymic selection and lineage commitment. , 2001, Current opinion in immunology.

[16]  E. Ward,et al.  Negative Selection during the Peripheral Immune Response to Antigen , 2001, The Journal of experimental medicine.

[17]  J. Kappler,et al.  T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo , 2000, The Journal of experimental medicine.

[18]  P. Romero,et al.  OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway , 2000, Nature Immunology.

[19]  P. Delves,et al.  The Immune System , 2000 .

[20]  L. Nicholson,et al.  Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity. , 2000, Cellular immunology.

[21]  M. Davis,et al.  A kinetic basis for T cell receptor repertoire selection during an immune response. , 1999, Immunity.

[22]  D. Busch,et al.  T Cell Affinity Maturation by Selective Expansion during Infection , 1999, The Journal of experimental medicine.

[23]  D. Mason,et al.  A very high level of crossreactivity is an essential feature of the T-cell receptor. , 1998, Immunology today.

[24]  Alessandro Sette,et al.  Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection , 1998, The Journal of experimental medicine.

[25]  César Milstein,et al.  Monitoring and interpreting the intrinsic features of somatic hypermutation , 1998, Immunological reviews.

[26]  R. Houghten,et al.  Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. , 1998, Journal of immunology.

[27]  A. Sette,et al.  Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[28]  M. Croft,et al.  Augmentation of naive, Th1 and Th2 effector CD4 Responses by IL‐6, IL‐1 and TNF , 1998, European journal of immunology.

[29]  Hervé Groux,et al.  A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.

[30]  Bernhard Hemmer,et al.  Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone , 1997, The Journal of experimental medicine.

[31]  Z. Grossman,et al.  Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. D. de Vries,et al.  Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells , 1996, The Journal of experimental medicine.

[33]  J. Berzofsky,et al.  Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[34]  P. Allen,et al.  Essential flexibility in the T-cell recognition of antigen , 1996, Nature.

[35]  M. Cohn,et al.  Two signal models of lymphocyte activation? , 1993, Immunology today.

[36]  Z. Grossman,et al.  Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[37]  A. Suhrbier,et al.  Role of single amino acids in the recognition of a T cell epitope. , 1991, Journal of Immunology.

[38]  L. Hood,et al.  RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[39]  H. Ploegh,et al.  The cell biology of antigen presentation. , 2002, Experimental cell research.

[40]  E. Shevach.  Regulatory T cells in autoimmmunity*. , 2000, Annual review of immunology.

[41]  Z Reich,et al.  Ligand recognition by alpha beta T cell receptors. , 1998, Annual review of immunology.

[42]  V. Kuchroo,et al.  Pathogenic versus protective repertoires in autoimmune disease: Tuning the balance , 1998 .

[43]  R. Phillips,et al.  Escape of human immunodeficiency virus from immune control. , 1997, Annual review of immunology.

[44]  P. Matzinger.  Tolerance, danger, and the extended family. , 1994, Annual review of immunology.

[45]  P. Beverley,et al.  Is T-cell memory maintained by crossreactive stimulation? , 1990, Immunology today.

[46]  D. Green,et al.  Immunoregulatory T-cell pathways. , 1983, Annual review of immunology.