Prenatal stress and cognitive development and temperament in infants

Studies in rodents and nonhuman primates indicate that maternal stress during pregnancy can influence the developing fetus, resulting in delay of motor and cognitive development and impaired adaptation to stressful situations. These effects may be mediated by the hypothalamic-pituitary-adrenal (HPA) axis. We examined whether stress during pregnancy predicted developmental outcome of human infants in a prospective design. Self-report data about daily hassles and pregnancy-specific anxiety and salivary cortisol levels were collected in nulliparous pregnant women. Dependent measures were scores on the Bayley Scales of Infant Development and on temperamental questionnaires at 3 and 8 months. Pregnancy-specific anxiety in mid pregnancy predicted lower mental and motor developmental scores at 8 months. Early morning values of cortisol in late pregnancy were negatively related to both mental and motor development at 3 months and motor development at 8 months. Pregnancy-specific anxiety explained 7% of the variance of test-affectivity and goal-directedness at 8 months. Increased maternal stress during pregnancy seems to be one of the determinants of temperamental variation and delay of development of infants and may be a risk factor for developing psychopathology later in life.

[1]  G. Sackett,et al.  Maternal Exposure to Stress during Pregnancy: Its Significance for Infant Behavior in Pigtail Macaques (Macaca nemestrina) , 1995 .

[2]  M. Le Moal,et al.  Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion , 1997, The Journal of Neuroscience.

[3]  R. Sapolsky.  The Importance of a Well-Groomed Child , 1997, Science.

[4]  G. Keshet,et al.  Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats. , 1996, Developmental psychobiology.

[5]  B. V. D. Bergh.  Maternal emotions during pregnancy and fetal and neonatal behavior , 1991 .

[6]  S. Rimm-Kaufman,et al.  Prenatal stress alters brain biogenic amine levels in primates , 1998, Development and Psychopathology.

[7]  J. Feldon,et al.  Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats , 1986, Physiology & Behavior.

[8]  O. Pryds,et al.  PRENATAL STRESSORS OF HUMAN LIFE AFFECT FETAL BRAIN DEVELOPMENT , 1994, Developmental medicine and child neurology.

[9]  A. Clarke,et al.  Prenatal stress has long-term effects on behavioral responses to stress in juvenile rhesus monkeys. , 1993, Developmental psychobiology.

[10]  M. Le Moal,et al.  Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[11]  N. Kalin,et al.  Prenatal stress potentiates stress-induced behavior and reduces the propensity to play in juvenile rats , 1992, Physiology & Behavior.

[12]  Mary L. Schneider.  Delayed Object Permanence Development in Prenatally Stressed Rhesus Monkey Infants (Macaca Mulatta) , 1992 .

[13]  R. Sapolsky,et al.  Hippocampal damage associated with prolonged glucocorticoid exposure in primates , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[14]  G. Lubach,et al.  Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. , 1999, Child development.

[15]  P. Piazza,et al.  Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers , 1992, Brain Research.

[16]  K. Fuxe,et al.  Prenatal development of glucocorticoid receptor gene expression and immunoreactivity in the rat brain and pituitary gland: a combined in situ hybridization and immunocytochemical analysis. , 1993, Neuroendocrinology.

[17]  T. Gray,et al.  Peptide injections into the amygdala of conscious rats: effects on blood pressure, heart rate and plasma catecholamines , 1988, Regulatory Peptides.

[18]  Mary L. Schneider,et al.  The effect of mild stress during pregnancy on birthweight and neuromotor maturation in rhesus monkey infants () , 1992 .

[19]  D. DeSantis,et al.  The mother-litter relationship in developmental rat studies: cannibalism vs caring. , 1984, Developmental psychobiology.

[20]  C. Coe,et al.  Repeated Social Stress during Pregnancy Impairs Neuromotor Development of the Primate Infant , 1993, Journal of developmental and behavioral pediatrics : JDBP.

[21]  M. Weinstock.  Does Prenatal Stress Impair Coping and Regulation of Hypothalamic-Pituitary-Adrenal Axis? , 1997, Neuroscience & Biobehavioral Reviews.

[22]  N. Bayley.  Manual for the Bayley Scales of Infant Development , 1969 .

[23]  A. Huizink.  Prenatal stress and its effect on infant development , 2000 .

[24]  A. Azzaro,et al.  Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces , 1995, Brain Research.

[25]  D. Abbott,et al.  Long-term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys. , 1994, Developmental psychobiology.

[26]  Shakti Sharma,et al.  Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. , 1995, Brain research. Developmental brain research.

[27]  I. Weiner,et al.  Differential Effects of Prenatal Stress in Two Inbred Strains of Rats , 1998, Pharmacology Biochemistry and Behavior.

[28]  S. Shelton,et al.  Neurotoxicity of Glucocorticoids in the Primate Brain , 1994, Hormones and Behavior.

[29]  M. Pagel,et al.  Psychosocial influences on new born outcomes: a controlled prospective study. , 1990, Social science & medicine.

[30]  J. Bates,et al.  Measurement of infant difficultness. , 1979, Child development.

[31]  M. Meaney,et al.  The Role of Early Environmental Events in Regulating Neuroendocrine Development: Moms, Pups, Stress, and Glucocorticoid Receptors , 1996, Annals of the New York Academy of Sciences.

[32]  B. L. Smith,et al.  The effects of prenatal stress on rat offsprings' learning ability. , 1981, The Journal of psychology.

[33]  Aviva Wakshlak,et al.  Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress , 1990, Physiology & Behavior.

[34]  H. Simon,et al.  Prenatal Stress Increases the Hypothalamo‐Pituitary‐Adrenal Axis Response in Young and Adult Rats , 1994, Journal of neuroendocrinology.

[35]  R. Poulton,et al.  Prevalence and correlates of cannabis use and dependence in young New Zealanders. , 1997, The New Zealand medical journal.

[36]  A J Ferreira,et al.  EMOTIONAL FACTORS IN PRENATAL ENVIRONMENT A Review , 1965, The Journal of nervous and mental disease.

[37]  J. Stern,et al.  Failure of severe maternal stress or ACTH during pregnancy to affect emotionality of male rat offspring: implications of litter effects for prenatal studies. , 1979, Developmental psychobiology.

[38]  H. Simon,et al.  Long-term effects of prenatal stress and handling on metabolic parameters: relationship to corticosterone secretion response , 1996, Brain Research.

[39]  B. McEwen,et al.  Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat , 1992, Brain Research.

[40]  M. Le Moal,et al.  Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress , 1996, The Journal of Neuroscience.

[41]  M. Weinstock,et al.  Prenatal stress effects on functional development of the offspring. , 1988, Progress in brain research.

[42]  D. Men,et al.  Effect of prenatal stress on plasma corticosterone and catecholamines in response to footshock in rats , 1998, Physiology & Behavior.

[43]  Y. Ichitani,et al.  Maternal stress induces synaptic loss and developmental disabilities of offspring , 1998, International Journal of Developmental Neuroscience.