Autologous serum eyedrops: literature review and implications for transfusion medicine specialists

Persistent corneal epithelial defects (CEDs) are caused by many diseases that are usually associated with decreased production of tears or reduced corneal sensitivity. Although surgical treatments are available for severe cases, CEDs are still difficult for ophthalmologists to treat.

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[2]  W. Sekundo,et al.  Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy. , 2006, American journal of ophthalmology.

[3]  T. Wedel,et al.  Corneal epitheliotrophic capacity of three different blood-derived preparations. , 2006, Investigative ophthalmology & visual science.

[4]  T. Wedel,et al.  Combination of serum eye drops with hydrogel bandage contact lenses in the treatment of persistent epithelial defects , 2006, Graefe's Archive for Clinical and Experimental Ophthalmology.

[5]  P. Prabhasawat,et al.  Sterility of non-preservative eye drops. , 2005, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

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[7]  T. Wedel,et al.  An optimised protocol for the production of autologous serum eyedrops , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[8]  K. Tsubota,et al.  The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study. , 2005, American journal of ophthalmology.

[9]  T. Wedel,et al.  Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: a potential agent for the treatment of ocular surface defects? , 2004, Transfusion.

[10]  G. Geerling,et al.  Autologous serum eye drops for ocular surface disorders , 2004, British Journal of Ophthalmology.

[11]  B. Seitz,et al.  [Sterility of non-preserved autologous serum drops for treatment of persistent corneal epithelial defects]. , 2004, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[12]  B. Seitz,et al.  Sterilitätskontrolle von unkonservierten Eigenserumtropfen bei therapieresistenten Hornhautepitheldefekten , 2004, Der Ophthalmologe.

[13]  D. Lam,et al.  The use of autologous serum tears in persistent corneal epithelial defects , 2004, Eye.

[14]  K. Tsubota,et al.  Autologous serum application in the treatment of neurotrophic keratopathy. , 2004, Ophthalmology.

[15]  K. Pesudovs,et al.  Comparison of autologous serum eye drops with conventional therapy in a randomised controlled crossover trial for ocular surface disease , 2004, British Journal of Ophthalmology.

[16]  H. Dua,et al.  A protocol for low contamination risk of autologous serum drops in the management of ocular surface disorders , 2004, British Journal of Ophthalmology.

[17]  D. Mccarty,et al.  In vivo effects of fluoroquinolones on rabbit corneas , 2003, Clinical & experimental ophthalmology.

[18]  K. Tsubota,et al.  Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease , 2003, Bone Marrow Transplantation.

[19]  C. Creuzot-Garcher,et al.  Treatment of Persistent Corneal Epithelial Defects by Autologous Serum , 2002 .

[20]  J. M. D. del Castillo,et al.  Treatment of Recurrent Corneal Erosions Using Autologous Serum , 2002, Cornea.

[21]  R. Gurny,et al.  Ocular tolerance of preservatives and alternatives. , 2002, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[22]  K. Tsubota,et al.  Treatment of Superior Limbic Keratoconjunctivitis by Application of Autologous Serum , 2001, Cornea.

[23]  H. Taylor,et al.  Controlled Study of the Use of Autologous Serum in Dry Eye Patients , 2001, Cornea.

[24]  J. Daniels,et al.  Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies , 2001, The British journal of ophthalmology.

[25]  U. Adiguzel,et al.  Effects of Topical Vitamin E on Keratocyte Apoptosis after Traditional Photorefractive Keratectomy , 2001, Ophthalmologica.

[26]  A. Lambiase,et al.  Topical treatment with nerve growth factor for neurotrophic keratitis. , 2000, Ophthalmology.

[27]  A. Vigorito,et al.  GVHD dry eyes treated with autologous serum tears , 2000, Bone Marrow Transplantation.

[28]  C. Sotozono,et al.  Growth factors: importance in wound healing and maintenance of transparency of the cornea , 2000, Progress in Retinal and Eye Research.

[29]  K. Tsubota,et al.  Treatment of persistent corneal epithelial defect by autologous serum application. , 1999, Ophthalmology.

[30]  S. Wilson,et al.  Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. , 1999, Investigative ophthalmology & visual science.

[31]  A. Lambiase,et al.  Topical treatment with nerve growth factor for corneal neurotrophic ulcers. , 1998, The New England journal of medicine.

[32]  K. Tsubota,et al.  Treatment of dry eye by autologous serum application in Sjögren’s syndrome , 1998, The British journal of ophthalmology.

[33]  C. Murphy,et al.  Synergistic effect of substance P with epidermal growth factor on epithelial migration in rabbit cornea. , 1997, Experimental eye research.

[34]  G. Bartley.  Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. , 1996, American journal of ophthalmology.

[35]  C. Murphy,et al.  Synergistic effects of substance P with insulin‐like growth factor‐1 on epithelial migration of the cornea , 1996, Journal of cellular physiology.

[36]  M. Boulton,et al.  The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes , 1996, Graefe's Archive for Clinical and Experimental Ophthalmology.

[37]  B. Holden,et al.  Fibronectin in the tear film. , 1996, Investigative ophthalmology & visual science.

[38]  M. Nakamura,et al.  Hyaluronan stimulates corneal epithelial migration. , 1991, Experimental eye research.

[39]  S. Kinoshita,et al.  The mechanism of accelerated corneal epithelial healing by human epidermal growth factor. , 1990, Investigative ophthalmology & visual science.

[40]  P. McDonnell,et al.  Immunoglobulin deposition in the cornea after application of autologous serum. , 1988, Archives of ophthalmology.

[41]  J. Belmont,et al.  Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. , 1984, Arthritis and rheumatism.

[42]  E. Manseau,et al.  Ulceration is correlated with degradation of fibrin and fibronectin at the corneal surface. , 1983, Investigative ophthalmology & visual science.

[43]  G. Stern,et al.  Effect of topical antibiotic solutions on corneal epithelial wound healing. , 1983, Archives of ophthalmology.

[44]  J. Lanigan,et al.  Fibronectin in healing rabbit corneal wounds. , 1981, Laboratory investigation; a journal of technical methods and pathology.

[45]  G. Smolin,et al.  Tretinoin and corneal epithelial wound healing. , 1979, Archives of ophthalmology.

[46]  J. Clarke,et al.  Medicine , 1907, Bristol medico-chirurgical journal.

[47]  K. Tsubota,et al.  Autologous serum eye drops for dry eye after LASIK. , 2006, Journal of refractive surgery.

[48]  M. Berry,et al.  Toxicity of antibiotics and antifungals on cultured human corneal cells: Effect of mixing, exposure and concentration , 1995, Eye.

[49]  R. J. Mack,et al.  An in vitro method which assesses corneal epithelial toxicity due to antineoplastic, preservative and antimicrobial agents. , 1989, Lens and eye toxicity research.