论文信息 - Microwave‐Accelerated Dimroth Rearrangement for the Synthesis of 4‐Anilino‐6‐nitroquinazolines. Application to an Efficient Synthesis of a Microtubule Destabilizing Agent.

Microwave‐Accelerated Dimroth Rearrangement for the Synthesis of 4‐Anilino‐6‐nitroquinazolines. Application to an Efficient Synthesis of a Microtubule Destabilizing Agent.

A variety of substituted anilines is applied to the reaction with cyanophenyl dimethylimidoformamide substrates (I) and (VIII) under microwave-assisted conditions and atmospheric pressure to afford the desired 4-anilinoquinazolines (III) or (IX).

[1] C. Corbière,et al. Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent , 2010 .