Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

[1]  J. Zheng,et al.  Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. , 1991, Science.

[2]  J. Pines,et al.  Cyclins and their associated cyclin-dependent kinases in the human cell cycle. , 1993, Biochemical Society transactions.

[3]  J. Harper,et al.  Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. , 1993, Molecular biology of the cell.

[4]  B. Franza,et al.  cdc2 phosphorylation is required for its interaction with cyclin. , 1991 .

[5]  S. Reed,et al.  Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast , 1991, Cell.

[6]  W. Kabsch,et al.  Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features , 1983, Biopolymers.

[7]  M. Ewen,et al.  A‐ and B‐type cyclins differentially modulate substrate specificity of cyclin‐cdk complexes. , 1993, The EMBO journal.

[8]  F. Zindy,et al.  Localization of cyclin A at the sites of cellular DNA replication. , 1993, Experimental cell research.

[9]  James M. Roberts,et al.  Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals , 1994, Cell.

[10]  B. Lee,et al.  The interpretation of protein structures: estimation of static accessibility. , 1971, Journal of molecular biology.

[11]  R. Hjelm Resolution of Time-of-Flight Small-Angle Neutron Diffractometers , 1987 .

[12]  David O. Morgan,et al.  A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase , 1994, Cell.

[13]  T. Hunt,et al.  Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. , 1992, Molecular biology of the cell.

[14]  S. Kim,et al.  Purification and crystallization of human cyclin-dependent kinase 2. , 1993, Journal of molecular biology.

[15]  P. Fitzgerald MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement , 1988 .

[16]  David M. Livingston,et al.  Functional interactions of the retinoblastoma protein with mammalian D-type cyclins , 1993, Cell.

[17]  Tony Hunter,et al.  Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2 , 1989, Cell.

[18]  D. Knighton,et al.  A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites , 1993, Molecular and cellular biology.

[19]  S. Reed,et al.  A family of cyclin homologs that control the G1 phase in yeast. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[20]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[21]  Nguyen-Huu Xuong,et al.  Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor , 1993 .

[22]  P. Fitzgerald,et al.  Molecular replacement , 1992 .

[23]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[24]  B. Kemp,et al.  Insights into autoregulation from the crystal structure of twitchin kinase , 1994, Nature.

[25]  Don C. Wiley,et al.  Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen , 1994, Nature.

[26]  J. Maller,et al.  Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells , 1989, Molecular and cellular biology.

[27]  Sung-Hou Kim,et al.  Crystal structure of cyclin-dependent kinase 2 , 1993, Nature.

[28]  B. Dynlacht,et al.  Differential regulation of E2F transactivation by cyclin/cdk2 complexes. , 1994, Genes & development.

[29]  T. Hunt,et al.  Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region. , 1990, Genes & development.

[30]  K. Sharp,et al.  Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons , 1991, Proteins.

[31]  E. Lees,et al.  Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase , 1993, Molecular and cellular biology.

[32]  Susan S. Taylor,et al.  Three protein kinase structures define a common motif. , 1994, Structure.

[33]  J. Pines,et al.  The cell cycle kinases. , 1994, Seminars in cancer biology.

[34]  M. Solomon,et al.  Activation of the various cyclin/cdc2 protein kinases. , 1993, Current opinion in cell biology.

[35]  C. Sherr G1 phase progression: Cycling on cue , 1994, Cell.

[36]  J. Sack,et al.  CHAIN — A crystallographic modeling program , 1988 .

[37]  James M. Roberts,et al.  Rules to replicate by , 1994, Cell.

[38]  D. Morgan,et al.  Activation of human cyclin-dependent kinases in vitro. , 1992, Molecular biology of the cell.

[39]  David O. Morgan,et al.  Principles of CDK regulation , 1995, Nature.

[40]  S. Hubbard,et al.  Crystal structure of the tyrosine kinase domain of the human insulin receptor , 1994, Nature.

[41]  M. Kirschner,et al.  Mitosis in transition , 1994, Cell.

[42]  Elizabeth J. Goldsmith,et al.  Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution , 1994, Nature.

[43]  Brian W. Matthews,et al.  An efficient general-purpose least-squares refinement program for macromolecular structures , 1987 .

[44]  E. Nigg,et al.  Targets of cyclin-dependent protein kinases. , 1993, Current opinion in cell biology.

[45]  R M Sweet,et al.  Crystal structure of casein kinase‐1, a phosphate‐directed protein kinase. , 1995, The EMBO journal.

[46]  Randy J. Read,et al.  Experiences with a new translation-function program , 1987 .