Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 Expression Using Targeted Contrast‐Enhanced High‐Frequency Ultrasonography

The aim of our study was to investigate the use of targeted contrast‐enhanced high‐frequency ultrasonography for molecular imaging of vascular endothelial growth factor receptor 2 (VEGFR2) expression on tumor vascular endothelium in murine models of breast cancer.

[1]  Marcela Brissova,et al.  Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. , 2004, Diabetes.

[2]  E Biganzoli,et al.  Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

[3]  Jonathan R. Lindner,et al.  Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to &agr;v-Integrins , 2003, Circulation.

[4]  M. van Glabbeke,et al.  New guidelines to evaluate the response to treatment in solid tumors , 2000, Journal of the National Cancer Institute.

[5]  Jonathan R. Lindner,et al.  Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to &agr;v&bgr;3 , 2003 .

[6]  William R Wagner,et al.  Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. , 2005, Cancer research.

[7]  Julie Morris,et al.  Assessment of Vascularity in Histological Sections: Effects of Methodology and Value as an Index of Angiogenesis in Breast Tumours , 1998, The Histochemical Journal.

[8]  Jiri Sklenar,et al.  Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. , 2003, Circulation.

[9]  J. Minna,et al.  Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. , 2000, Cancer research.

[10]  T. McShane,et al.  Development and Use of Biomarkers in Oncology Drug Development , 2004, Toxicologic pathology.

[11]  M Van Glabbeke,et al.  New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. , 2000, Journal of the National Cancer Institute.

[12]  Frank D Sistare,et al.  Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity , 2004, Toxicologic pathology.

[13]  Thomas Boehm,et al.  Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance , 1997, Nature.

[14]  Olivier Lucidarme,et al.  Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. , 2006, Radiology.

[15]  J. Folkman.  What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.