Formulation of artemisinin tablets

Abstract Since artemisinin is known to be absorbed very fast from gastrointestinal fluid, while its solubility is very low, the formulation of the dosage form may be an important factor that might limit absorption after oral administration. The purpose of this investigation was to study the influences of some formulation variables on the time required to achieve a fast and complete dissolution of artemisinin. An experimental design that generated a maximum of information for a minimum of experimental work was used. The response selected for the factorial design was the time required for dissolution of 50% of the content ( T 50 ), determined with a previous described two phase partition-dissolution method.