Paradoxical pupil responses to isolated M-cone increments.

M-cone onsets appear dimmer than the background and elicit electroretinograms (ERGs) resembling the light offset response. We sought a corresponding anomalous pupillary light reflex (PLR) using a 4-primary ganzfeld as stimulator and pupillometer. Increments and decrements of white light were compared with M- and L-cone onsets and offsets using silent substitution. Luminance bias (LB) could be added to or subtracted from the cone-isolating stimuli. There was a normal PLR to L-cone increments, but the pupil constricted mainly to M-cone decrements. Changing LB produced a neutral point where on and off responses were balanced. The results reflect ERG and psychophysical studies. This observation may be linked to the antagonistic nature of the M-cone input to cone opponent mechanisms.

[1]  M. Gordijn,et al.  Melanopsin- and L-cone–induced pupil constriction is inhibited by S- and M-cones in humans , 2018, Proceedings of the National Academy of Sciences.

[2]  J. Kremers,et al.  Rod Electroretinograms Elicited by Silent Substitution Stimuli from the Light-Adapted Human Eye , 2016, Translational vision science & technology.

[3]  J. Kremers,et al.  A dim view of M-cone onsets. , 2016, Journal of the Optical Society of America. A, Optics, image science, and vision.

[4]  J. J. McAnany,et al.  Effect of stimulus size and luminance on the rod-, cone-, and melanopsin-mediated pupillary light reflex. , 2015, Journal of vision.

[5]  D. Brainard,et al.  Opponent melanopsin and S-cone signals in the human pupillary light response , 2014, Proceedings of the National Academy of Sciences.

[6]  J. Kremers,et al.  Incremental and decremental L- and M-cone-driven ERG responses: I. Square-wave pulse stimulation. , 2014, Journal of the Optical Society of America. A, Optics, image science, and vision.

[7]  J. D. Mollon,et al.  Can spatial resolution reveal individual differences in the L:M cone ratio? , 2013, Vision Research.

[8]  J. Yellott,et al.  A unified formula for light-adapted pupil size. , 2012, Journal of vision.

[9]  A. Kijlstra,et al.  Epidemiology of Ocular Toxoplasmosis , 2012, Ocular immunology and inflammation.

[10]  Paul R. Martin,et al.  Retinal connectivity and primate vision , 2010, Progress in Retinal and Eye Research.

[11]  M. Bradley,et al.  The pupil as a measure of emotional arousal and autonomic activation. , 2008, Psychophysiology.

[12]  T. Badea,et al.  Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision , 2008, Nature.

[13]  Jay Neitz,et al.  The L:M cone ratio in males of African descent with normal color vision. , 2008, Journal of vision.

[14]  J. Pokorny,et al.  Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells , 2007, Vision Research.

[15]  J. Pokorny,et al.  Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN , 2005, Nature.

[16]  J. L. Barbur,et al.  Comparison of pupil responses to luminance and colour in severe optic neuritis , 2004, Clinical Neurophysiology.

[17]  K. Yau,et al.  Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice , 2003, Science.

[18]  Jay Neitz,et al.  Estimates of L:M cone ratio from ERG flicker photometry and genetics. , 2002, Journal of vision.

[19]  R. Shapley,et al.  Space and Time Maps of Cone Photoreceptor Signals in Macaque Lateral Geniculate Nucleus , 2002, The Journal of Neuroscience.

[20]  A. Stockman,et al.  The spectral sensitivities of the middle- and long-wavelength-sensitive cones derived from measurements in observers of known genotype , 2000, Vision Research.

[21]  L Weiskrantz,et al.  Differential pupillary constriction and awareness in the absence of striate cortex. , 1999, Brain : a journal of neurology.

[22]  J L Barbur,et al.  Visual processing levels revealed by response latencies to changes in different visual attributes , 1998, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[23]  Paul D. Gamlin,et al.  Pupil responses to stimulus color, structure and light flux increments in the rhesus monkey , 1998, Vision Research.

[24]  P A Stanley,et al.  The effect of field of view size on steady-state pupil diameter. , 1995, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[25]  David J. Calkins,et al.  M and L cones in macaque fovea connect to midget ganglion cells by different numbers of excitatory synapses , 1994, Nature.

[26]  J. Werner,et al.  Spectral efficiency across the life span: flicker photometry and brightness matching. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[27]  D. Whitaker,et al.  Factors affecting light-adapted pupil size in normal human subjects. , 1994, Investigative ophthalmology & visual science.

[28]  Peter K. Kaiser,et al.  Sensation luminance: A new name to distinguish CIE luminance from luminance dependent on an individual's spectral sensitivity , 1988, Vision Research.

[29]  C. R. Ingling.  The spectral sensitivity of the opponent-color channels , 1977, Vision Research.

[30]  L. Benevento,et al.  An autoradiographic study of the projections of the pretectum in the rhesus monkey (macaca mulatta): evidence for sensorimotor links to the thalamus and oculomotor nuclei , 1977, Brain Research.

[31]  H. Bouma,et al.  Size of the Static Pupil as a Function of Wave-length and Luminosity of the Light Incident on the Human Eye , 1962, Nature.

[32]  F. Campbell.  Refractive Errors of the Human Eye , 1957, Nature.

[33]  H. Vries,et al.  Luminosity Curve of Trichromats , 1946, Nature.

[34]  B. H. Crawford.  The dependence of pupil size upon external light stimulus under static and variable conditions , 1936 .

[35]  S. Yasuda,et al.  Separation process of two-phase fluids , 2005, J. Vis..