Modification of reproductive function in the rat by 3-methylcholanthrene.

Repeated exposure of adult female Wistar rats to 3-methylcholanthrene (MC) (25 mg kg(-1) b.w., i.p., 2xwk, 1 mo) was associated with a significant increase in estrus cycle length. In addition, an increased frequency of females with constant diestrus and abnormal cycles was observed. Young females which had been exposed to MC prepubertally or whose parents had been treated with MC before and during mating also demonstrated cycle prolongation and an increased incidence of constant diestrus and abnormal cycles. These changes in female reproductive function were not associated with measurable changes in plasma sex hormone levels. In contrast, MC exposure in adult males was associated with significant reductions in circulating plasma testosterone levels. The present data also suggest that the offspring of parents who had been exposed repeatedly to MC before and during mating are also affected. Although the central nervous system in offspring of MC-treated parents appeared to be intact, their oral body temperature was significantly lower.

[1]  Robert W. Moore,et al.  Inhibition of testicular steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats: evidence that the key lesion occurs prior to or during pregnenolone formation. , 1990, Toxicology and applied pharmacology.

[2]  T. Umbreit,et al.  Alteration of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by estradiol and tamoxifen. , 1989, Toxicology.

[3]  J. Olson,et al.  Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. , 1989, Toxicology letters.

[4]  T. Umbreit,et al.  Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1988, Toxicology letters.

[5]  M. Romkes,et al.  Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. , 1988, Toxicology and applied pharmacology.

[6]  C. Spyraki,et al.  Behavioural and biochemical effects of haloperidol during the oestrous cycle of the rat , 1988, Neuropharmacology.

[7]  M. Romkes,et al.  Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic and uterine estrogen receptor levels in rats. , 1987, Toxicology and applied pharmacology.

[8]  P. Hornsby,et al.  Methylcholanthrene: a possible pseudosubstrate for adrenocortical 17 alpha-hydroxylase and aryl hydrocarbon hydroxylase. , 1986, Biochemical pharmacology.

[9]  R. Ebright,et al.  Binding of 2-hydroxybenzo(a)pyrene to estrogen receptors in rat cytosol. , 1986, Cancer research.

[10]  N. Schwartz,et al.  Measurement of serum steroid and gonadotropin levels and uterine and ovarian variables throughout 4 day and 5 day estrous cycles in the rat. , 1979, Biology of reproduction.

[11]  C. Spyraki,et al.  Implication of the estrous cycle on conditioned avoidance behavior in the rat , 1978, Physiology & Behavior.

[12]  D. Toft,et al.  A distinction between 3-methylcholanthrene and estrogen binding in the uterus. , 1972, Cancer research.

[13]  R. Moon,et al.  Anti-uterotrophic Response of Immature Mice to 3-Methylcholanthrene , 1969, Nature.

[14]  M. Marselos,et al.  Sexual differentiation in the induction of the class 3 aldehyde dehydrogenase. , 1993, Advances in experimental medicine and biology.

[15]  D. Benford,et al.  Drug metabolism from molecules to man , 1987 .