Goals and Analytical Methodologies for Protein Disposition Studies

This chapter will present an overview of the goals of protein disposition studies and some of the analytical tools used to achieve those goals. The examples cited in the goals portion of this chapter will be briefly presented since these will be explored in greater depth in the ensuing chapters. Analytical issues are of major concern in protein disposition studies since many of the standard protein analysis methods do not individually provide a positive identification of the analyte. The question of which existing methodologies and analytical technologies are most productive will be addressed.