Mitochondrial dynamics in model organisms: what yeasts, worms and flies have taught us about fusion and fission of mitochondria.

[1]  S. Rolland,et al.  The BCL-2–like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion , 2009, The Journal of cell biology.

[2]  Victor S. Van Laar,et al.  Mitochondrial dynamics in Parkinson's disease , 2009, Experimental Neurology.

[3]  J. Martinou,et al.  Role of mitofusin 2 mutations in the physiopathology of Charcot–Marie–Tooth disease type 2A , 2009, Experimental Neurology.

[4]  P. Reddy,et al.  Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease , 2009, Experimental Neurology.

[5]  Marc Liesa,et al.  Mitochondrial dynamics in mammalian health and disease. , 2009, Physiological reviews.

[6]  K. White,et al.  Inside an enigma: do mitochondria contribute to cell death in Drosophila? , 2009, Apoptosis.

[7]  B. Westermann Nitric Oxide Links Mitochondrial Fission to Alzheimer’s Disease , 2009, Science Signaling.

[8]  J. Blerkom Mitochondria in early mammalian development. , 2009 .

[9]  M. Karbowski,et al.  Mitochondrial fusion and division: Regulation and role in cell viability. , 2009, Seminars in cell & developmental biology.

[10]  J. McCaffery,et al.  Mitochondrial outer and inner membrane fusion requires a modified carrier protein , 2009, The Journal of cell biology.

[11]  A. Fire,et al.  CED-9 and mitochondrial homeostasis in C. elegans muscle , 2008, Journal of Cell Science.

[12]  Hansong Deng,et al.  The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila , 2008, Proceedings of the National Academy of Sciences.

[13]  M. Dunham,et al.  Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects , 2008, Cell Death and Differentiation.

[14]  S. Mitani,et al.  Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. , 2008, Molecular cell.

[15]  L. Saraíva,et al.  Mitochondria-dependent apoptosis in yeast. , 2008, Biochimica et biophysica acta.

[16]  R. Youle,et al.  Mitochondrial dynamics and apoptosis. , 2008, Genes & development.

[17]  R. Lill,et al.  Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases. , 2008, Annual review of biochemistry.

[18]  A. M. van der Bliek,et al.  The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. , 2008, Molecular biology of the cell.

[19]  Benedikt Westermann,et al.  Molecular Machinery of Mitochondrial Fusion and Fission* , 2008, Journal of Biological Chemistry.

[20]  M. Beal,et al.  Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery , 2008, Proceedings of the National Academy of Sciences.

[21]  S. Jakobs,et al.  The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae , 2008, The Journal of cell biology.

[22]  K. Mihara,et al.  An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in Caenorhabditis elegans. , 2008, Journal of biochemistry.

[23]  C. Mannella,et al.  The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals , 2008, PLoS genetics.

[24]  D. Wallace,et al.  The Molecular Mechanisms of OPA1-Mediated Optic Atrophy in Drosophila Model and Prospects for Antioxidant Treatment , 2008, PLoS genetics.

[25]  D. Chan,et al.  Functions and dysfunctions of mitochondrial dynamics , 2007, Nature Reviews Molecular Cell Biology.

[26]  Kara L. Cerveny,et al.  Regulation of mitochondrial fusion and division. , 2007, Trends in cell biology.

[27]  B. Westermann,et al.  Molecular machinery of mitochondrial dynamics in yeast , 2007, Biological chemistry.

[28]  K. Funato,et al.  Ethanol‐induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway , 2007, FEBS letters.

[29]  K. White,et al.  Mitochondrial disruption in Drosophila apoptosis. , 2007, Developmental cell.

[30]  R. Youle,et al.  Role of Mitochondrial Remodeling in Programmed Cell Death in Drosophila melanogaster , 2007, Developmental cell.

[31]  Matt Kaeberlein,et al.  Recent Developments in Yeast Aging , 2007, PLoS genetics.

[32]  J. Nunnari The machines that divide and fuse mitochondria , 2007, Annual review of biochemistry.

[33]  K. G. Hales,et al.  Roles for Drp1, a Dynamin-related Protein, and Milton, a Kinesin-associated Protein, in Mitochondrial Segregation, Unfurling, and Elongation During Drosophila Spermatogenesis , 2007, Fly.

[34]  D. Stojanovski,et al.  Mitochondrial morphology and distribution in mammalian cells , 2006, Biological chemistry.

[35]  M. Priault,et al.  Evaluation of the Roles of Apoptosis, Autophagy, and Mitophagy in the Loss of Plating Efficiency Induced by Bax Expression in Yeast* , 2006, Journal of Biological Chemistry.

[36]  Rachel M. Devay,et al.  Mitochondrial Inner-Membrane Fusion and Crista Maintenance Requires the Dynamin-Related GTPase Mgm1 , 2006, Cell.

[37]  R. Youle,et al.  Role of Bax and Bak in mitochondrial morphogenesis , 2006, Nature.

[38]  D. Chan Mitochondrial fusion and fission in mammals. , 2006, Annual review of cell and developmental biology.

[39]  M. Beal,et al.  Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[40]  D. Chan Mitochondria: Dynamic Organelles in Disease, Aging, and Development , 2006, Cell.

[41]  Sunhong Kim,et al.  Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin , 2006, Nature.

[42]  Changan Jiang,et al.  Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin , 2006, Nature.

[43]  M. Freeman,et al.  Normal Mitochondrial Dynamics Requires Rhomboid-7 and Affects Drosophila Lifespan and Neuronal Function , 2006, Current Biology.

[44]  J. Hayashi,et al.  Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA. , 2006, Biochimica et biophysica acta.

[45]  A. Santel Get the balance right: mitofusins roles in health and disease. , 2006, Biochimica et biophysica acta.

[46]  V. Mils,et al.  Mitochondrial dynamics and disease, OPA1. , 2006, Biochimica et biophysica acta.

[47]  D. Logan Plant mitochondrial dynamics. , 2006, Biochimica et biophysica acta.

[48]  J. Martinou,et al.  Mitochondrial fission and apoptosis: an ongoing trial. , 2006, Biochimica et biophysica acta.

[49]  Colin Adrain,et al.  Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics. , 2006, Molecular cell.

[50]  J. Shaw,et al.  Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. , 2005, Annual review of genetics.

[51]  B. Westermann,et al.  Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. , 2005, Molecular biology of the cell.

[52]  H. Jungwirth,et al.  Yeast caspase 1 links messenger RNA stability to apoptosis in yeast , 2005, EMBO reports.

[53]  Emily M. Coonrod,et al.  The role of Fis1p–Mdv1p interactions in mitochondrial fission complex assembly , 2005, The Journal of cell biology.

[54]  J. McCaffery,et al.  Dnm1 forms spirals that are structurally tailored to fit mitochondria , 2005, The Journal of cell biology.

[55]  P. Verstreken,et al.  Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions , 2005, Neuron.

[56]  J. Hardwick,et al.  Viruses activate a genetically conserved cell death pathway in a unicellular organism , 2005, The Journal of cell biology.

[57]  Erik E. Griffin,et al.  The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria , 2005, The Journal of cell biology.

[58]  Robert S. Balaban,et al.  Mitochondria, Oxidants, and Aging , 2005, Cell.

[59]  R. Jagasia,et al.  DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans , 2005, Nature.

[60]  A. Hyman,et al.  Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast , 2005, The Journal of cell biology.

[61]  H. Jungwirth,et al.  Apoptosis in yeast. , 2004, Current opinion in microbiology.

[62]  Hyeong-Cheol Yang,et al.  Live Cell Imaging of Mitochondrial Movement along Actin Cables in Budding Yeast , 2004, Current Biology.

[63]  J. Pevsner,et al.  Mitochondrial fission proteins regulate programmed cell death in yeast. , 2004, Genes & development.

[64]  J. Shaw,et al.  Importance of mitochondrial dynamics during meiosis and sporulation. , 2004, Molecular biology of the cell.

[65]  J. McCaffery,et al.  Mitochondrial Fusion Intermediates Revealed in Vitro , 2004, Science.

[66]  R. Jensen,et al.  Ugo1p Links the Fzo1p and Mgm1p GTPases for Mitochondrial Fusion* , 2004, Journal of Biological Chemistry.

[67]  D. Pain,et al.  A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. , 2004, The Biochemical journal.

[68]  A. M. van der Bliek,et al.  Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria* , 2004, Journal of Biological Chemistry.

[69]  V. Reinke,et al.  Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans , 2003, Development.

[70]  J. Nunnari,et al.  The Division of Endosymbiotic Organelles , 2003, Science.

[71]  J. Martinou,et al.  hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery* , 2003, Journal of Biological Chemistry.

[72]  R. Jensen,et al.  Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion. , 2003, Biochemical and biophysical research communications.

[73]  M. McNiven,et al.  The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1 , 2003, Molecular and Cellular Biology.

[74]  A. Reichert,et al.  Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA* , 2003, Journal of Biological Chemistry.

[75]  B. Lemire,et al.  The role of mitochondria in the life of the nematode, Caenorhabditis elegans. , 2003, Biochimica et biophysica acta.

[76]  M. Herrler,et al.  Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells , 2003, Journal of Cell Science.

[77]  M. Freeman,et al.  Mitochondrial membrane remodelling regulated by a conserved rhomboid protease , 2003, Nature.

[78]  S. Hell,et al.  Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p , 2003, Journal of Cell Science.

[79]  T. Kirchhausen,et al.  Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. , 2003, Molecular biology of the cell.

[80]  G. Lenaers,et al.  Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis* , 2003, The Journal of Biological Chemistry.

[81]  S. Jakobs,et al.  The inner membrane protein Mdm33 controls mitochondrial morphology in yeast , 2003, The Journal of cell biology.

[82]  J. Nunnari,et al.  The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion , 2003, The Journal of cell biology.

[83]  A. Santel,et al.  Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn , 2002, Mechanisms of Development.

[84]  Erik M. Jorgensen,et al.  The art and design of genetic screens: Caenorhabditis elegans , 2002, Nature Reviews Genetics.

[85]  A. Lombès,et al.  Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. , 2002, Journal of cell science.

[86]  Stefan Fritz,et al.  Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. , 2002, Molecular biology of the cell.

[87]  Daniel St Johnston,et al.  The art and design of genetic screens: Drosophila melanogaster , 2002, Nature Reviews Genetics.

[88]  R. Jensen,et al.  UGO1 Encodes an Outer Membrane Protein Required for Mitochondrial Fusion , 2001, The Journal of cell biology.

[89]  W. Neupert,et al.  Connection of the Mitochondrial Outer and Inner Membranes by Fzo1 Is Critical for Organellar Fusion , 2001, The Journal of cell biology.

[90]  Kara L. Cerveny,et al.  Yeast mitochondrial dynamics: Fusion, division, segregation, and shape , 2000, Microscopy research and technique.

[91]  J. Shaw,et al.  The Dynamin-Related Gtpase, Mgm1p, Is an Intermembrane Space Protein Required for Maintenance of Fusion Competent Mitochondria , 2000, The Journal of cell biology.

[92]  J. Shaw,et al.  Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p , 2000, The Journal of cell biology.

[93]  J. Nunnari,et al.  Mdv1p Is a Wd Repeat Protein That Interacts with the Dynamin-Related Gtpase, Dnm1p, to Trigger Mitochondrial Division , 2000, The Journal of cell biology.

[94]  R. Jensen,et al.  Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape , 1999, The Journal of cell biology.

[95]  A. M. van der Bliek,et al.  C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. , 1999, Molecular cell.

[96]  J. Shaw,et al.  The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast , 1999, Nature Cell Biology.

[97]  M. Saraste Oxidative phosphorylation at the fin de siècle. , 1999, Science.

[98]  J. Thatcher,et al.  Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p , 1998, The Journal of cell biology.

[99]  J. Thatcher,et al.  The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast , 1998, The Journal of cell biology.

[100]  J C Reed,et al.  Mitochondria and apoptosis. , 1998, Science.

[101]  W. Neupert,et al.  Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae* , 1998, Journal of Biological Chemistry.

[102]  M. Fuller,et al.  Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis. , 1998, Seminars in cell & developmental biology.

[103]  K. G. Hales,et al.  Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase , 1997, Cell.

[104]  A. Murray,et al.  Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. , 1997, Molecular biology of the cell.

[105]  L. Avery,et al.  The genetics of feeding in Caenorhabditis elegans. , 1993, Genetics.

[106]  W. L. Fangman,et al.  Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin. , 1992, Genes & development.

[107]  T. Kuroiwa,et al.  Fluorescence microscopic studies of mitochondrial nucleoids during meiosis and sporulation in the yeast, Saccharomyces cerevisiae. , 1984, Journal of cell science.

[108]  K. Tokuyasu Dynamics of spermiogenesis in Drosophila melanogaster. VI. Significance of "onion" nebenkern formation. , 1975, Journal of ultrastructure research.

[109]  H P Hoffmann,et al.  Mitochondrion of Yeast: Ultrastructural Evidence for One Giant, Branched Organelle per Cell , 1973, Science.

[110]  T. Nyström,et al.  Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models , 2007, Nature Cell Biology.

[111]  Rowland H. Davis,et al.  The age of model organisms , 2004, Nature Reviews Genetics.

[112]  J. G. Kuenen,et al.  Effects of growth conditions on mitochondrial morphology inSaccharomyces cerevisiae , 2004, Antonie van Leeuwenhoek.

[113]  V. Skulachev,et al.  Mitochondrial filaments and clusters as intracellular power-transmitting cables. , 2001, Trends in biochemical sciences.

[114]  J. Shaw,et al.  Mitochondrial dynamics in yeast. , 1998, Annual review of cell and developmental biology.

[115]  L. Guarente,et al.  Aging in Saccharomyces cerevisiae. , 1998, Annual review of microbiology.

[116]  L. Pon,et al.  Mitochondrial inheritance: cell cycle and actin cable dependence of polarized mitochondrial movements in Saccharomyces cerevisiae. , 1997, Cell motility and the cytoskeleton.

[117]  J. Bereiter-Hahn,et al.  Behavior of mitochondria in the living cell. , 1990, International review of cytology.

[118]  W. Wood The Nematode Caenorhabditis elegans , 1988 .

[119]  J. Broach,et al.  The Molecular biology of the yeast saccharomyces, life cycle and inheritance , 1981 .