Validation of a biomechanical heart model using animal data with acute myocardial infarction

In this paper, we validate a biomechanical heart model with animal data providing a controlled infarct condition with a follow-up over several weeks. First, we set up the personalized model using data coming from the healthy animal, and we show that the simulations compare accurately with the measured data, both for the tissue motion and for the blood pressures. Then, we demonstrate that we can also adequately represent the behavior of the acutely infarcted heart by changing only the parameters directly related to the pathology, and to the physiological state of the subject during the exams.