Caging NLRP3 tames inflammasome activity

[1]  Hao Wu,et al.  NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation , 2021, Cell.

[2]  N. Stiefl,et al.  Crystal structure of NLRP3 NACHT domain with an inhibitor defines mechanism of inflammasome inhibition. , 2021, Journal of molecular biology.

[3]  G. López-Castejón,et al.  NLRP3 activation in response to disrupted endocytic traffic , 2021, bioRxiv.

[4]  J. Bonifacino,et al.  Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation , 2021, bioRxiv.

[5]  A. Tapia-Abellán,et al.  Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation , 2021, Science advances.

[6]  E. Latz,et al.  Cryo-EM structure of the NLRP3 decamer bound to the cytokine release inhibitory drug CRID3 , 2021, bioRxiv.

[7]  Youdong Mao,et al.  Structural mechanism for NEK7-licensed NLRP3 inflammasome activation , 2019, Nature.

[8]  J. Ting,et al.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.

[9]  A. Tapia-Abellán,et al.  NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway , 2018, Nature Communications.

[10]  Zhijian J. Chen,et al.  PtdIns4P on Dispersed Trans-Golgi Network Mediates NLRP3 Inflammasome Activation , 2018, Nature.

[11]  J. Duncan,et al.  The NLRC4 Inflammasome , 2018, Immunological reviews.

[12]  F. Martinon,et al.  A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses , 2007, Nature Immunology.