论文信息 - Saccadic dysmetria induced by transient functional decortication of the cerebellar vermis

Saccadic dysmetria induced by transient functional decortication of the cerebellar vermis

Saccadic dysmetria is seen in patients with cerebellar diseases as well as in monkeys whose vermis and fastigial nucleus are experimentally lesioned. We investigated the oculomotor signs of the vermis by blocking cerebellar impulses with bicuculline injections into the fastigial nucleus. The oculomotor abnormalities associated with the bicuculline treatment (in effect, functional as well as reversible, unilateral decortication of the vermis) were hypometric saccades toward the injection side and gaze deviation toward the opposite side. These oculomotor signs disappeared with the withdrawal of the bicuculline effect.

H. Sato | H. Noda | H. Sato | H. Noda

[1] Kisou Kubota,et al. Cortical projection to hand-arm motor area from post-arcuate area in macaque monkeys: A histological study of retrograde transport of horseradish peroxidase , 1979, Neuroscience Letters.

[2] P. Strick,et al. Frontal lobe inputs to primate motor cortex: evidence for four somatotopically organized ‘premotor’ areas , 1979, Brain Research.

[3] [Neurons with visual receptive fields independent of eye position in the caudal portion of the ventral wall of the cruciate sulcus of the cat cerebral cortex]. , 1986, Neirofiziologiia = Neurophysiology.

[4] J. Schlag,et al. Visual responses of thalamic neurons depending on the direction of gaze and the position of targets in space , 1980, Experimental Brain Research.