Systems level modeling of a neuronal network subserving intrinsic alertness

Cognitive control of alertness in unwarned situations (intrinsic alertness) relies on a predominantly right hemisphere cortical and subcortical network. In a previous functional activation study, we have demonstrated that this network comprises the anterior cingulate gyrus, the dorsolateral and polar frontal as well as the inferior parietal cortex, the thalamus and ponto-mesencephalic parts of the brain stem. The aim of this study was to study effective connectivity of this network by employing structural equation modeling. Fifteen right-handed male subjects participated in the PET study. The functional network showed stronger connectivity in the right hemisphere. Furthermore, there were strong effective connections between thalamus and brainstem on the one hand and between thalamus and anterior cingulate on the other. Our results suggest that the anterior cingulate functions as the central coordinating structure for the right hemispheric neural network of intrinsic alertness and that the anterior cingulate gyrus is modulated mainly by prefrontal and parietal cortex.

[1]  Jin Fan,et al.  The activation of attentional networks , 2005, NeuroImage.

[2]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[3]  Karl G. Jöreskog,et al.  Lisrel 8: User's Reference Guide , 1997 .

[4]  S. Dimond.  Performance by Split-Brain Humans on Lateralized Vigilance Tasks , 1979, Cortex.

[5]  A Berthoz,et al.  Functional Neuroanatomy of the Human Visual Fixation System , 1995, The European journal of neuroscience.

[6]  B. Gulyás,et al.  Activation by Attention of the Human Reticular Formation and Thalamic Intralaminar Nuclei , 1996, Science.

[7]  M. Raichle,et al.  Localization of a human system for sustained attention by positron emission tomography , 1991, Nature.

[8]  S. Black,et al.  Brain-behavior correlations in hemispatial neglect using CT and SPECT , 1998, Neurology.

[9]  Klaus Willmes,et al.  Is there a generalized right hemisphere dominance for mediating cerebral activation? Evidence from a choice reaction experiment with lateralized simple warning stimuli , 1989, Neuropsychologia.

[10]  J. Coyle,et al.  The differential effect of right versus left hemispheric cerebral infarction on catecholamines and behavior in the rat , 1980, Brain Research.

[11]  W. Sturn.  Evaluation in therapeutical contexts : Attentional and neglect disorders : Neuropsychology and evaluation , 1996 .

[12]  R. Dolan,et al.  The Neural Correlates of the Noradrenergic Modulation of Human Attention, Arousal and Learning , 1997, The European journal of neuroscience.

[13]  A. Nobre,et al.  The noradrenergic alpha2 agonist clonidine modulates behavioural and neuroanatomical correlates of human attentional orienting and alerting. , 2001, Cerebral cortex.

[14]  M. Sarter,et al.  The cognitive neuroscience of sustained attention: where top-down meets bottom-up , 2001, Brain Research Reviews.

[15]  T. Shallice,et al.  Frontal lesions and sustained attention , 1987, Neuropsychologia.

[16]  J. Mattingley,et al.  Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness , 1998, Nature.

[17]  Stephen J. Boies,et al.  Components of attention. , 1971 .

[18]  I. Radermacher,et al.  Functional anatomy of intrinsic alertness: evidencefor a fronto-parietal-thalamic-brainstem network in theright hemisphere , 1999, Neuropsychologia.

[19]  E. Làdavas,et al.  Is the hemispatial deficit produced by right parietal lobe damage associated with retinal or gravitational coordinates? , 1987, Brain : a journal of neurology.

[20]  T. Paus,et al.  Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies , 1998, Neuroreport.

[21]  Michael I. Posner,et al.  Brain Imaging of Attentional Networks in Normal and Pathological States , 2001, Journal of clinical and experimental neuropsychology.

[22]  J G Taylor,et al.  Network analysis in episodic encoding and retrieval of word‐pair associates: a PET study , 1999, The European journal of neuroscience.

[23]  Phan Luu,et al.  The Anterior Cingulate Cortex : Regulating Actions in Context , 2004 .

[24]  Michael S. Gazzaniga,et al.  Handbook of psychobiology , 1975 .

[25]  K. Heilman,et al.  Right hemispheric dominance for mediating cerebral activation , 1979, Neuropsychologia.

[26]  E. Favale,et al.  Simple reaction-time changes in patients with unilateral brain damage , 1986, Neuropsychologia.

[27]  M. Posner,et al.  Cognitive and emotional influences in anterior cingulate cortex , 2000, Trends in Cognitive Sciences.

[28]  Nadim Joni Shah,et al.  Decomposing memory: functional assignments and brain traffic in paired word associate learning , 2000, Neural Networks.

[29]  Karl J. Friston,et al.  Estimating Smoothness in Statistical Parametric Maps: Variability of p Values , 1995, Journal of computer assisted tomography.

[30]  Changiz Geula,et al.  Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: A choline acetyltransferase study , 1992, The Journal of comparative neurology.

[31]  T. Paus.  Primate anterior cingulate cortex: Where motor control, drive and cognition interface , 2001, Nature Reviews Neuroscience.

[32]  Karl J. Friston,et al.  Statistical parametric mapping , 2013 .

[33]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[34]  Alan C. Evans,et al.  Time-Related Changes in Neural Systems Underlying Attention and Arousal During the Performance of an Auditory Vigilance Task , 1997, Journal of Cognitive Neuroscience.

[35]  J G Beaumont,et al.  Difference in the vigilance performance of the right and left hemispheres. , 1973, Cortex; a journal devoted to the study of the nervous system and behavior.

[36]  J. Grafman,et al.  Sustained attention deficits in pat ients with right frontal lesions , 1996, Neuropsychologia.

[37]  A. McIntosh,et al.  Neural modeling, functional brain imaging, and cognition , 1999, Trends in Cognitive Sciences.

[38]  S Ekholm,et al.  Nonlateralized attentional deficits: an important component behind persisting visuospatial neglect? , 1998, Journal of clinical and experimental neuropsychology.

[39]  K. Willmes,et al.  Do Specific Attention Deficits Need Specific Training , 1997 .

[40]  Albrecht W. Inhoff,et al.  Isolating attentional systems: A cognitive-anatomical analysis , 1987, Psychobiology.

[41]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[42]  H. Critchley,et al.  Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans , 2000, The Journal of physiology.

[43]  J. Haxby,et al.  Network analysis of brain cognitive function using metabolic and blood flow data , 1995, Behavioural Brain Research.

[44]  Gereon R Fink,et al.  Cerebral correlates of alerting, orienting and reorienting of visuospatial attention: an event-related fMRI study , 2004, NeuroImage.

[45]  R. Robinson.  Differential behavioral and biochemical effects of right and left hemispheric cerebral infarction in the rat. , 1979, Science.

[46]  Alan C. Evans,et al.  Anticipation causes increased blood flow to the anterior cingulate cortex , 1996, Human brain mapping.

[47]  B. Berger,et al.  Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine‐beta‐hydroxylase , 1989, The Journal of comparative neurology.

[48]  N J Shah,et al.  On the relation between brain images and brain neural networks , 2000, Human brain mapping.

[49]  D. LaBerge,et al.  Positron emission tomographic measurements of pulvinar activity during an attention task , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[50]  A. McIntosh,et al.  Structural modeling of functional visual pathways mapped with 2-deoxyglucose: effects of patterned light and footshock , 1992, Brain Research.

[51]  Klaus Willmes,et al.  Network for auditory intrinsic alertness: a PET study , 2004, Neuropsychologia.

[52]  J. Lewin,et al.  Cortical localization of human sustained attention: detection with functional MR using a visual vigilance paradigm. , 1996, Journal of computer assisted tomography.

[53]  M. Posner.  The Cognitive Neuroscience of Attention , 2020 .

[54]  Karl J. Friston,et al.  Noradrenergically Mediated Plasticity in a Human Attentional Neuronal Network , 1999, NeuroImage.

[55]  Robert G. Robinson,et al.  7 – Lateralized Behavioral and Neurochemical Consequences of Unilateral Brain Injury in Rats , 1985 .

[56]  I..  THE ATTENTION SYSTEM OF THE HUMAN BRAIN , 2002 .

[57]  Leslie G. Ungerleider,et al.  Network analysis of cortical visual pathways mapped with PET , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[58]  Diego Fernandez-Duque,et al.  Relating the mechanisms of orienting and alerting , 1997, Neuropsychologia.

[59]  Karl J. Friston,et al.  Lateralized Cognitive Processes and Lateralized Task Control in the Human Brain , 2003, Science.

[60]  M. Botvinick,et al.  The Contribution of the Anterior Cingulate Cortex to Executive Processes in Cognition , 1999, Reviews in the neurosciences.

[61]  F. Boller,et al.  Simple reaction time: evidence for focal impairment from lesions of the right hemisphere. , 1975, Brain : a journal of neurology.

[62]  W. Brouwer,et al.  Clinical Neuropsychology of Attention , 1994 .