Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7.
暂无分享,去创建一个
E. De Clercq | Dongwei Kang | Boshi Huang | C. Pannecouque | P. Zhan | Xinyong Liu | D. Daelemans | Chin-Ho Chen | K. Lee | Zhao Wang | Lin Sun | Ping Gao | Zhuo Li | Songkai Sun
[1] Qigui Yu,et al. Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity , 2019, Journal of medicinal chemistry.
[2] E. Clercq. Fifty Years in Search of Selective Antiviral Drugs , 2019 .
[3] J. Deschamps,et al. Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. , 2018, Chemistry.
[4] E. De Clercq,et al. Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. , 2018, European journal of medicinal chemistry.
[5] E. De Clercq,et al. First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. , 2018, Bioorganic & medicinal chemistry letters.
[6] S. de Castro,et al. Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy? , 2018, European journal of medicinal chemistry.
[7] O. Tabarrini,et al. NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors. , 2017, Drug discovery today.
[8] A. Wang,et al. Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus , 2016, Antiviral Research.
[9] Peng Zhan,et al. Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends. , 2016, Journal of medicinal chemistry.
[10] P. Zhan,et al. [Research progress of dual inhibitors targeting HIV-1 reverse transcriptase and integrase]. , 2013, Yao xue xue bao = Acta pharmaceutica Sinica.
[11] X Liu,et al. Rationally designed multitarget anti-HIV agents. , 2013, Current medicinal chemistry.
[12] K. Anderson,et al. Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase. , 2012, Journal of molecular biology.
[13] E. Appella,et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. , 2010, Nature chemical biology.
[14] Li Huang,et al. Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. , 2009, Journal of medicinal chemistry.
[15] Peng Zhan,et al. Designed multiple ligands: an emerging anti-HIV drug discovery paradigm. , 2009, Current pharmaceutical design.
[16] Y. Pommier,et al. Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by α-Hydroxytropolones , 2006, Molecular Pharmacology.
[17] P. T. Jørgensen,et al. Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach. , 2005, Journal of medicinal chemistry.
[18] H. W. Scheeren,et al. Elongated multiple electronic cascade and cyclization spacer systems in activatible anticancer prodrugs for enhanced drug release. , 2001, The Journal of organic chemistry.
[19] C. Nguyen,et al. Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase. , 2000, Journal of medicinal chemistry.
[20] H. W. Scheeren,et al. Novel anthracycline-spacer-beta-glucuronide,-beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapy. , 1999, Bioorganic & medicinal chemistry.
[21] H. Langtry,et al. Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. , 1989, Drugs.
[22] C. Pannecouque,et al. Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later , 2008, Nature Protocols.
[23] A Ward,et al. Pentoxifylline , 1987, Drugs.