Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.

[1]  B. Winblad,et al.  Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. , 2003, The American journal of pathology.

[2]  R. Nitsch,et al.  Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A , 2002, The European journal of neuroscience.

[3]  Katrin Engelmann,et al.  cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner , 2002, Oncogene.

[4]  P. Lefebvre,et al.  Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter , 2002, Molecular and Cellular Biology.

[5]  T. Herdegen,et al.  c-Jun N-Terminal Protein Kinase (JNK) 2/3 Is Specifically Activated by Stress, Mediating c-Jun Activation, in the Presence of Constitutive JNK1 Activity in Cerebellar Neurons , 2002, The Journal of Neuroscience.

[6]  D. Flood,et al.  Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition , 2002, The Journal of Neuroscience.

[7]  A. Davis,et al.  Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Xiongwei Zhu,et al.  Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis , 2001, Mechanisms of Ageing and Development.

[9]  B. Ghetti,et al.  Activation of the JNK/p38 Pathway Occurs in Diseases Characterized by Tau Protein Pathology and Is Related to Tau Phosphorylation But Not to Apoptosis , 2001, Journal of neuropathology and experimental neurology.

[10]  R. Nitsch,et al.  Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. , 2001, The Journal of biological chemistry.

[11]  R. Nitsch,et al.  Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils , 2001, Science.

[12]  Jürgen Götz,et al.  Tau and transgenic animal models , 2001, Brain Research Reviews.

[13]  P. Vogt,et al.  Jun, the oncoprotein , 2001, Oncogene.

[14]  J. Trojanowski,et al.  PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus , 2001, Experimental Neurology.

[15]  C. Crosio,et al.  Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 Cells* , 2001, The Journal of Biological Chemistry.

[16]  J. Uney,et al.  Inhibition of JNK by Overexpression of the JNK Binding Domain of JIP-1 Prevents Apoptosis in Sympathetic Neurons* , 2001, The Journal of Biological Chemistry.

[17]  T. Shanley,et al.  The Serine/Threonine Phosphatase, PP2A: Endogenous Regulator of Inflammatory Cell Signaling1 , 2001, The Journal of Immunology.

[18]  R. Nitsch,et al.  Tau Filament Formation in Transgenic Mice Expressing P301L Tau* , 2001, The Journal of Biological Chemistry.

[19]  Xiongwei Zhu,et al.  Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease , 2001, Journal of neurochemistry.

[20]  P. Greengard,et al.  Neuron‐Specific Phosphorylation of Alzheimer's β‐Amyloid Precursor Protein by Cyclin‐Dependent Kinase 5 , 2000, Journal of neurochemistry.

[21]  B. Metzler,et al.  Increased expression and activation of stress-activated protein kinases/c-Jun NH(2)-terminal protein kinases in atherosclerotic lesions coincide with p53. , 2000, The American journal of pathology.

[22]  R. Nitsch,et al.  Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development , 2000, Mechanisms of Development.

[23]  J. Wegiel,et al.  Phosphorylation of Microtubule-associated Protein Tau Is Regulated by Protein Phosphatase 2A in Mammalian Brain , 2000, The Journal of Biological Chemistry.

[24]  Melvin G McInnis,et al.  Expansion of a novel CAG trinucleotide repeat in the 5′ region of PPP2R2B is associated with SCA12 , 1999, Nature Genetics.

[25]  Y. Kurimoto,et al.  BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. , 1999, Investigative ophthalmology & visual science.

[26]  G. Bloom,et al.  Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules , 1999, The Journal of Biological Chemistry.

[27]  J. Hofsteenge,et al.  Functional Expression of Human PP2Ac in Yeast Permits the Identification of Novel C-terminal and Dominant-negative Mutant Forms* , 1999, The Journal of Biological Chemistry.

[28]  N. Holbrook,et al.  Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. , 1999, Neuroreport.

[29]  D. Brautigan,et al.  Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression. , 1999, Cellular signalling.

[30]  P. Greengard,et al.  Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation , 1999, The Journal of Neuroscience.

[31]  B. Hemmings,et al.  Regulation of protein kinase cascades by protein phosphatase 2A. , 1999, Trends in biochemical sciences.

[32]  P. Hof,et al.  Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration , 1999, Acta Neuropathologica.

[33]  G. Perry,et al.  Apoptosis and Alzheimer's disease [5] , 1998 .

[34]  A. Wolfman,et al.  Oncogenic Ha-Ras-dependent Mitogen-activated Protein Kinase Activity Requires Signaling Through the Epidermal Growth Factor Receptor* , 1998, The Journal of Biological Chemistry.

[35]  B. Hemmings,et al.  Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Mutsuhiro Takekawa,et al.  Protein phosphatase 2Cα inhibits the human stress‐responsive p38 and JNK MAPK pathways , 1998, The EMBO journal.

[37]  T. Hunter,et al.  Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury , 1998, The Journal of Neuroscience.

[38]  I. Grundke‐Iqbal,et al.  The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases , 1998, FEBS letters.

[39]  D. McCance,et al.  Rb binds c‐Jun and activates transcription , 1998, The EMBO journal.

[40]  F. Ebner,et al.  Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits , 1998, The Journal of comparative neurology.

[41]  Min Han,et al.  The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk‐1 phosphorylation from MAP kinase activation , 1998, The EMBO journal.

[42]  J. Kocsis,et al.  Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo , 1998, The Journal of Neuroscience.

[43]  Alphonse García,et al.  Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF‐κB activation , 1997 .

[44]  K. Matsushima,et al.  Stimulation of Interleukin-8 Production by Okadaic Acid and Vanadate in a Human Promyelocyte Cell Line, an HL-60 Subline , 1997, The Journal of Biological Chemistry.

[45]  H. Rubinfeld,et al.  Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  B. Anderton,et al.  Stress‐Activated Protein Kinase/c‐Jun N‐Terminal Kinase Phosphorylates τ Protein , 1997, Journal of neurochemistry.

[47]  P. Stork,et al.  Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo* , 1997, The Journal of Biological Chemistry.

[48]  R. Crowther,et al.  Characterization of mAb AP422, a novel phosphorylation‐dependent monoclonal antibody against tau protein , 1996 .

[49]  M. Goedert,et al.  Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase , 1995 .

[50]  I. Grundke‐Iqbal,et al.  Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain , 1995, Journal of neurochemistry.

[51]  Kun-Liang Guan,et al.  Isolation and Characterization of a Novel Dual Specific Phosphatase, HVH2, Which Selectively Dephosphorylates the Mitogen-activated Protein Kinase (*) , 1995, The Journal of Biological Chemistry.

[52]  P. Cohen,et al.  Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines , 1995, Current Biology.

[53]  P. Greengard,et al.  Immunocytochemical localization of amyloid precursor protein in rat brain , 1994, The Journal of comparative neurology.

[54]  B. Taillon,et al.  STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p. , 1994, The Journal of biological chemistry.

[55]  P. Greengard,et al.  Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. , 1994, The EMBO journal.

[56]  E. Krebs,et al.  Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. , 1993, The Journal of biological chemistry.

[57]  G. Drewes,et al.  Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer‐like state. , 1992, The EMBO journal.

[58]  P. Cohen,et al.  Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases , 1991, Nature.

[59]  J. Maller,et al.  Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase , 1990, Nature.

[60]  L. Mahadevan,et al.  Transcription: MAPK-regulated transcription: a continuously variable gene switch? , 2002, Nature Reviews Molecular Cell Biology.

[61]  E. Sontag.  Protein phosphatase 2A: the Trojan Horse of cellular signaling. , 2001, Cellular signalling.

[62]  R. Nitsch,et al.  Human Tau Transgenic Mice , 2001 .

[63]  R. Nitsch,et al.  Human tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation. , 2001, Advances in experimental medicine and biology.

[64]  C. Behl,et al.  Apoptosis and Alzheimer's disease , 2000, Journal of Neural Transmission.

[65]  S. Shenolikar,et al.  Protein serine/threonine phosphatases--new avenues for cell regulation. , 1994, Annual review of cell biology.