Case Report: Clinical and Procedural Implications of Ommaya Reservoir Implantation in Cystic Brain Metastases Followed by Radiosurgery Treatment

Background Therapy for large or deep cystic brain metastases is a troublesome procedure in clinical departments. Stereotactic cyst aspiration, combined with Gamma Knife radiosurgery, can be an effective treatment for cystic brain metastases. However, there is still a possibility that a reaccumulation of cystic fluid may lead to poor efficacy or even reoperation. Case presentation We present a case of a 67-year-old man who was diagnosed with lung cancer brain metastasis. The intracranial lesion seen on imaging appeared to be cystic and located deep inside the brain with associated limb dysfunction. The patient did not respond well to chemotherapy and underwent cyst aspiration with Ommaya reservoir implantation under neuronavigation. Repeated cystic fluid reaccumulation and exacerbation of symptoms occurred during treatment. We performed repeated aspiration via the Ommaya reservoir to control the symptoms and combined it with radiotherapy. During the follow-up period of 14 months, the intracranial tumor was effectively and satisfactorily controlled. Conclusions We highlight that Ommaya reservoir implantation during stereotactic cyst aspiration is necessary to prevent fluid reaccumulation, thereby avoiding the need for a second surgical procedure.

[1]  Yiping Zhang,et al.  Treatment and Prognosis of Solid and Cystic Brain Metastases in Patients with Non-Small-Cell Lung Cancer , 2021, Cancer management and research.

[2]  S. Leenstra,et al.  Stereotactic cyst aspiration directly followed by Gamma Knife radiosurgery for large cystic brain metastases , 2020, Acta Neurochirurgica.

[3]  N. Erez,et al.  A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis. , 2019, Cancer research.

[4]  J. Olson,et al.  Hemorrhagic and Cystic Brain Metastases Are Associated With an Increased Risk of Leptomeningeal Dissemination After Surgical Resection and Adjuvant Stereotactic Radiosurgery. , 2018, Neurosurgery.

[5]  K. Kawai,et al.  Optimal implantation of Ommaya reservoirs for cystic metastatic brain tumors preceding Gamma Knife radiosurgery , 2017, Journal of Clinical Neuroscience.

[6]  Shikai Wu,et al.  Cystic brain metastasis is associated with poor prognosis in patients with advanced breast cancer , 2016, Oncotarget.

[7]  R. Foroni,et al.  Radiosurgical Options in Neuro-oncology: A Review on Current Tenets and Future Opportunities. Part II: Adjuvant Radiobiological Tools , 2015, Tumori.

[8]  Shin Jung,et al.  Alternative Treatment of Stereotactic Cyst Aspiration and Radiosurgery for Cystic Brain Metastases , 2014, Stereotactic and Functional Neurosurgery.

[9]  R. Foroni,et al.  Radiosurgical Options in Neuro-oncology: A Review on Current Tenets and Future Opportunities. Part I: Therapeutic Strategies , 2014, Tumori.

[10]  James R. Fink,et al.  Imaging of brain metastases , 2013, Surgical neurology international.

[11]  Fumi Higuchi,et al.  Effectiveness of a 1-day aspiration plus Gamma Knife surgery procedure for metastatic brain tumor with a cystic component. , 2012, Journal of neurosurgery.

[12]  D. Kondziolka,et al.  The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline , 2009, Journal of Neuro-Oncology.

[13]  Won Hyoung Park,et al.  Gamma knife radiosurgery after stereotactic aspiration for large cystic brain metastases. , 2009, Journal of Korean Neurosurgical Society.

[14]  A. Bolognesi,et al.  Stereotactic drainage and Gamma Knife radiosurgery of cystic brain metastasis. , 2008, Journal of neurosurgery.

[15]  T. Shuto,et al.  Ommaya reservoir placement followed by Gamma Knife surgery for large cystic metastatic brain tumors. , 2006, Journal of neurosurgery.

[16]  J. Sheehan,et al.  Gamma knife surgery for brain metastases from lung cancer. , 2005, Journal of neurosurgery.

[17]  S. Yoshida,et al.  The role of surgery in the treatment of brain metastasis: a retrospective review , 2004, Acta Neurochirurgica.

[18]  K. Ericson,et al.  Tumor seeding following stereotactic biopsy of brain metastases. Report of two cases. , 1997, Journal of neurosurgery.

[19]  W. Gardner,et al.  Cystic brain tumors and the blood-brain barrier. Comparison of protein fractions in cyst fluids and sera. , 1963, Archives of neurology.

[20]  Henry Southern,et al.  The retrospective review , 1820 .