Alcohol and female puberty: the role of intraovarian systems.

Alcohol consumption during early adolescence may suppress the secretion of specific female reproductive hormones, thereby delaying puberty and adversely affecting the maturation of the reproductive system. These effects occur through several mechanisms, including altered production and secretion by the ovaries of estradiol, a key steroid hormone involved in the timing and regulation of female reproductive events. Alcohol can affect estradiol production by interfering with the normal function of regulatory hormones produced by the brain and the pituitary gland. Recent research has demonstrated additional potential mechanisms for alcohol's effects on female reproductive capability, including interference with specific regulatory systems located entirely within the ovary. Such "intraovarian" systems include the insulin-like growth factor-1 (IGF-1) and nitric oxide (NO) systems. Alcohol can dampen the stimulatory effects of the ovarian IGF-1 system and can increase the inhibitory effects of the ovarian NO system. These effects combine to decrease estradiol secretion. Thus, alcohol impairs ovarian function not only by interfering with hormonal communication between the brain, pituitary gland, and ovaries but also by directly altering the function of regulatory systems within the ovaries themselves. These results provide further evidence of the risks of underage drinking and the importance of its prevention.

[1]  S. Ojeda,et al.  Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. , 1996, Endocrinology.

[2]  A. Root,et al.  Effects of drug and alcohol abuse upon pituitary-testicular function in adolescent males. , 1986, Journal of adolescent health care : official publication of the Society for Adolescent Medicine.

[3]  C. Skelley,et al.  Effects of ethanol during the onset of female puberty. , 1990, Neuroendocrinology.

[4]  Van,et al.  Expression and localization of inducible and endothelial nitric oxide synthase in the rat ovary. Effects of gonadotropin stimulation in vivo. , 1995, The Journal of clinical investigation.

[5]  V. Srivastava,et al.  Ovarian nitric oxide synthase (NOS) gene expression during peripubertal development. , 1997, Life sciences.

[6]  J. Tentler,et al.  The effect of "binge" ethanol exposure on growth hormone and prolactin gene expression and secretion. , 1992, Endocrinology.

[7]  M. Naassila,et al.  Ethanol potentiates lipopolysaccharide- or interleukin-1 beta-induced nitric oxide generation in RBE4 cells. , 1996, European journal of pharmacology.

[8]  J. Hammond,et al.  Comparative effects of insulin and insulin-like growth factors on DNA synthesis and differentiation of porcine granulosa cells. , 1984, Biochemical and biophysical research communications.

[9]  V. Srivastava,et al.  Alcohol's effects on female puberty: the role of insulin-like growth factor 1. , 1998 .

[10]  L. J. Chandler,et al.  Ethanol enhances the endothelial nitric oxide synthase response to agonists. , 1993, Hypertension.

[11]  E. Adashi,et al.  Interleukin-1 beta stimulates nitrite production in the rat ovary: evidence for heterologous cell-cell interaction and for insulin-mediated regulation of the inducible isoform of nitric oxide synthase. , 1994, Biology of reproduction.

[12]  G. Kozlowski,et al.  Ethanol and the pulsatile release of luteinizing hormone, follicle stimulating hormone and prolactin in ovariectomized rats. , 1985, Alcohol.

[13]  M. Mcdaniel,et al.  Nitric oxide mediates interleukin-1-induced cellular cytotoxicity in the rat ovary. A potential role for nitric oxide in the ovulatory process. , 1993, The Journal of clinical investigation.

[14]  V. Srivastava,et al.  Effect of ethanol on the synthesis of insulin-like growth factor 1 (IGF-1) and the IGF-1 receptor in late prepubertal female rats: a correlation with serum IGF-1. , 1995, Alcoholism, clinical and experimental research.

[15]  A. Tsafriri,et al.  The involvement of nitric oxide in the ovulatory process in the rat. , 1994, Endocrinology.

[16]  D. Magoffin,et al.  Insulin-like growth factor-I regulates aromatase activity in human granulosa and granulosa luteal cells. , 1989, The Journal of clinical endocrinology and metabolism.

[17]  A. Jablonka-Shariff,et al.  Nitric oxide decreases estradiol synthesis of rat luteinized ovarian cells: possible role for nitric oxide in functional luteal regression. , 1996, Endocrinology.

[18]  D. Monniaux,et al.  Control of proliferation and differentiation of ovine granulosa cells by insulin-like growth factor-I and follicle-stimulating hormone in vitro. , 1992, Biology of reproduction.

[19]  G. Kozlowski,et al.  Differential effects of ethanol on luteinizing hormone, follicle stimulating hormone and prolactin secretion in the female rat. , 1984, Alcohol.

[20]  P. Rotwein,et al.  Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. , 1989, Endocrine reviews.

[21]  M. Mitchell,et al.  Transient suppression of growth hormone secretion after chronic ethanol intake. , 1978, Alcoholism, clinical and experimental research.

[22]  G. Redmond.  Effect of ethanol on endogenous rhythms of growth hormone secretion. , 1980, Alcoholism, clinical and experimental research.

[23]  A. Bartke,et al.  The endocrine system: an overview. , 1998 .

[24]  A. Jablonka-Shariff,et al.  Hormonal Regulation of Nitric Oxide Synthases and Their Cell-Specific Expression during Follicular Development in the Rat Ovary1. , 1997, Endocrinology.

[25]  M. Karube,et al.  Growth hormone stimulates follicular development by stimulating ovarian production of insulin-like growth factor-I. , 1994, Endocrinology.

[26]  V. Srivastava,et al.  Effects of ethanol on the intraovarian insulin-like growth factor-1 system in the prepubertal rat. , 1999, Alcoholism, clinical and experimental research.