Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

[1]  M. Fornai,et al.  Pharmacological modulation of adenosine receptor pathways and inflammatory disorders: the way towards novel therapeutics? , 2011, Expert opinion on investigational drugs.

[2]  P. Pacher,et al.  Investigational A3 adenosine receptor targeting agents , 2011, Expert opinion on investigational drugs.

[3]  B. Fischer,et al.  Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. , 2011, Journal of medicinal chemistry.

[4]  R. Schinazi,et al.  Advances in nucleoside monophosphate prodrugs as anti-HCV agents , 2010, Antiviral therapy.

[5]  R. Schinazi,et al.  Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs , 2009, Antiviral chemistry & chemotherapy.

[6]  G. Qu,et al.  Synthesis of novel C6-phosphonated purine nucleosides under microwave irradiation by SNAr-Arbuzov reaction. , 2008, The Journal of organic chemistry.

[7]  S. Gessi,et al.  Adenosine receptor antagonists: translating medicinal chemistry and pharmacology into clinical utility. , 2008, Chemical reviews.

[8]  A. Burger,et al.  Inhibition of adenosine deaminase by analogues of adenosine and inosine, incorporating a common heterocyclic base, 4(7)-amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one. , 2008, Journal of medicinal chemistry.

[9]  W. Greenlee,et al.  3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists. , 2007, Bioorganic & medicinal chemistry letters.

[10]  A. Unciti-Broceta,et al.  Reduction of different electron-poor N-heteroarylhydrazines in strong basic conditions. , 2007, Chemistry.

[11]  Xiaofen Li,et al.  N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists. , 2007, Bioorganic & medicinal chemistry letters.

[12]  K. Jacobson,et al.  2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists. , 2006, Journal of medicinal chemistry.

[13]  R. Ptak,et al.  Nucleosides with self-complementary hydrogen-bonding motifs: synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system. , 2006, Bioorganic & medicinal chemistry.

[14]  R. Pohl,et al.  The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides. , 2005, Organic & biomolecular chemistry.

[15]  W. Stec,et al.  Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication. , 2005, Journal of medicinal chemistry.

[16]  R. Pohl,et al.  Highly Methylated Purines and Purinium Salts as Analogues of Heteromines , 2005 .

[17]  D. Hlasta,et al.  Trimethylsilyl-directed 1,3-dipolar cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles. , 2005, Organic letters.

[18]  V. Nair,et al.  Facile, chemoenzymatic synthesis of the potent antiviral compound, 2-acetonylinosine , 2005 .

[19]  P. D. Cook,et al.  Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication. , 2004, Journal of medicinal chemistry.

[20]  R. Pohl,et al.  Facile and efficient synthesis of 6-(hydroxymethyl)purines. , 2004, Organic letters.

[21]  Quanlai Song,et al.  Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. , 2004, Journal of medicinal chemistry.

[22]  Hiroshi Sugiyama,et al.  8-Methylguanosine: a powerful Z-DNA stabilizer. , 2003, Journal of the American Chemical Society.

[23]  C. Mathé,et al.  Azido/Tetrazole Tautomerism in 2‐Azidoadenine β‐D‐Pentofuranonucleoside Derivatives , 2003 .

[24]  Michal Hocek,et al.  An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines. , 2003, The Journal of organic chemistry.

[25]  Lawrence C Kuo,et al.  Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs* , 2003, The Journal of Biological Chemistry.

[26]  M. Otto,et al.  Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture , 2003, Antimicrobial Agents and Chemotherapy.

[27]  M. Otto,et al.  Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues , 2002, Antimicrobial Agents and Chemotherapy.

[28]  D. Tyrrell,et al.  Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils. , 2001, Journal of medicinal chemistry.

[29]  G. Koomen,et al.  Synthesis and properties of 2-nitrosoadenosine , 2001 .

[30]  J. Reichen,et al.  Peginterferon alfa-2a in patients with chronic hepatitis C. , 2000, The New England journal of medicine.

[31]  A. IJzerman,et al.  2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes. , 2000, Bioorganic & medicinal chemistry letters.

[32]  E. Fiala,et al.  N2-amination of guanine to 2-hydrazinohypoxanthine, a novel in vivo nucleic acid modification produced by the hepatocarcinogen 2-nitropropane. , 1998, Chemical research in toxicology.

[33]  M. Wolfe,et al.  A Short, Flexible Route toward 2‘-C-Branched Ribonucleosides , 1997 .

[34]  D. Berry,et al.  Synthesis and Biological Activity of 4-Amino-1-(β-D-ribofuranosyl)imidazo[4,5-d]pyridazin-7-one , 1994 .

[35]  R. Noyori,et al.  O-selective phosphorylation of nucleosides without N-protection , 1993 .

[36]  R. Schinazi,et al.  Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1 , 1990, Antimicrobial Agents and Chemotherapy.