Laser surface modification of ultra-high-molecular-weight polyethylene (UHMWPE) for biomedical applications

Abstract Ultra-high-molecular-weight polyethylene (UHMWPE) is a synthetic polymer used for biomedical applications because of its high impact resistance, ductility and stability in contact with physiological fluids. Therefore, this material is being used in human orthopedic implants such as total hip or knee replacements. Surface modification of this material relates to changes on its chemistry, microstructure, roughness, and topography, all influencing its biological response. Surface treatment of UHMWPE is very difficult due to its high melt viscosity. This work presents a systematic approach to discern the role of different laser wavelengths ( λ  = 1064, 532, and 355 nm) on the surface modification of carbon coated UHMWPE samples. Influence of laser processing conditions (irradiance, pulse frequency, scanning speed, and spot overlapping) on the surface properties of this material was determined using an advanced statistical planning of experiments. A full factorial design of experiments was used to find the main effects of the processing parameters. The obtained results indicate the way to maximize surface properties which largely influence cell–material interaction.

[1]  J. Liu.  Simple technique for measurements of pulsed Gaussian-beam spot sizes. , 1982, Optics letters.

[2]  Paul C. Painter,et al.  The theory of vibrational spectroscopy and its application to polymeric materials , 1982 .

[3]  J. Fernández‐Pradas,et al.  Surface modification of UHMWPE with infrared femtosecond laser , 2012 .

[4]  M. Mohanty,et al.  Short term tissue response to carbon fibre: A preliminaryin vitro andin vivo study , 1998 .

[5]  H. Arzate,et al.  Biocompatibility, Cytotoxicity and Bioactivity of Amorphous Carbon Films , 2006 .

[6]  D. Lin-Vien.  The Handbook of Infrared and Raman Characteristic Frequencies of Organic Molecules , 1991 .

[7]  S. Ramakrishna,et al.  Biomedical applications of polymer-composite materials: a review , 2001 .

[8]  W. Mohr,et al.  The body reaction to carbon fibre particles implanted into the medullary space of rabbits. , 1981, Biomaterials.

[9]  Eal H. Lee,et al.  Ion beam application for improved polymer surface properties , 1993 .

[10]  J. Pou,et al.  Biological stability and osteoconductivity in rabbit tibia of pulsed laser deposited hydroxylapatite coatings. , 2006, Journal of biomedical materials research. Part A.

[11]  G. Strobl,et al.  Raman spectroscopic method for determining the crystallinity of polyethylene , 1978 .

[12]  B D Boyan,et al.  Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). , 1995, Journal of biomedical materials research.

[13]  Y. Ozaki,et al.  Raman spectra of high-density, low-density, and linear low-density polyethylene pellets and prediction of their physical properties by multivariate data analysis. , 2002 .

[14]  B. Binks.  Particles as surfactants—similarities and differences , 2002 .

[15]  S. Affatato,et al.  Effects of the sterilisation method on the wear of UHMWPE acetabular cups tested in a hip joint simulator. , 2002, Biomaterials.

[16]  Claude Martelet,et al.  Relationship between surface properties (roughness, wettability) of titanium and titanium alloys and cell behaviour , 2003 .

[17]  Zhili Sun,et al.  Structural and mechanical properties of nitrogen ion implanted ultra high molecular weight polyethylene , 2001 .

[18]  Mindaugas Gedvilas,et al.  Investigation of UV picosecond laser ablation of polymers , 2005, EPIC/SPIE Workshop on Laser Applications in Europe.

[19]  Xiaolong Zhu,et al.  Effects of topography and composition of titanium surface oxides on osteoblast responses. , 2004, Biomaterials.

[20]  Lourdes Díaz-Rodríguez,et al.  Effect of roughness, wettability and morphology of engineered titanium surfaces on osteoblast-like cell adhesion , 2010 .

[21]  V. Nassisi,et al.  Modification of polymer characteristics by laser and ion beam , 2010 .

[22]  Juan Pou,et al.  Laser surface modification of PEEK , 2012 .

[23]  C. Chan,et al.  Polymer surface modification by plasmas and photons , 1996 .

[24]  J. Lawrence,et al.  Wettability characteristics of polyethylene modified with CO2, Nd:YAG, excimer and high-power diode lasers , 2001 .