Focal epileptiform activity in the brain: detection with spike-related functional MR imaging--preliminary results.

The purpose of this study was to develop a spike-related functional magnetic resonance (MR) imaging method to detect epileptic brain activity. Correlations between simultaneous spike-related functional MR imaging and electroencephalographic (EEG) recordings were performed in 10 patients with focal epilepsy. Postprocessing techniques were implemented to eliminate contamination of the EEG recording from ballistocardiography and the echo-planar MR imaging sequence. A diagnostic EEG recording was achieved during functional MR imaging. Spike location correlated with the site of blood oxygen level-dependent signal increase. Spike-related functional MR imaging is a promising technique for detecting focal epileptic brain activity.

[1]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[2]  J R Ives,et al.  Echo-planar functional MR imaging of epilepsy with concurrent EEG monitoring. , 1999, AJNR. American journal of neuroradiology.

[3]  A Drzezga,et al.  Reduction of Benzodiazepine Receptor Binding is Related to the Seizure Onset Zone in Extratemporal Focal Cortical Dysplasia , 2000, Epilepsia.

[4]  M E Phelps,et al.  Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3 , 1980, Annals of neurology.

[5]  C. Binnie,et al.  Clinical Value of “Ictal” FDG‐Positron Emission Tomography and the Routine Use of Simultaneous Scalp EEG Studies in Patients with Intractable Partial Epilepsies , 1998, Epilepsia.

[6]  K J Werhahn,et al.  Electromyography in MRI—First recordings of peripheral nerve activation caused by fast magnetic field gradients , 2000, Magnetic resonance in medicine.

[7]  R. Cox,et al.  Event‐related fMRI contrast when using constant interstimulus interval: Theory and experiment , 2000, Magnetic resonance in medicine.

[8]  J H Duyn,et al.  Steady state effects in fast gradient echo magnetic resonance imaging , 1997, Magnetic resonance in medicine.

[9]  S Warach,et al.  Monitoring the patient's EEG during echo planar MRI. , 1993, Electroencephalography and clinical neurophysiology.

[10]  M. Weiner,et al.  Temporal lobe epilepsy: qualitative reading of 1H MR spectroscopic images for presurgical evaluation. , 2001, Radiology.

[11]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[12]  B N Cuffin,et al.  Accuracy of electroencephalographic dipole localization of epileptiform activities associated with focal brain lesions , 1998, Annals of neurology.

[13]  Oliver Speck,et al.  Functional spectroscopy of brain activation following a single light pulse: Examinations of the mechanism of the fast initial response , 1995, Int. J. Imaging Syst. Technol..

[14]  T A Yousry,et al.  Topography of the cortical motor hand area: prospective study with functional MR imaging and direct motor mapping at surgery. , 1995, Radiology.

[15]  Michael E. Phelps,et al.  Comparative localization of foci in partial epilepsy by PCT and EEG , 1982 .

[16]  L. Lemieux,et al.  Recording of EEG during fMRI experiments: Patient safety , 1997, Magnetic resonance in medicine.

[17]  A. Drzezga,et al.  18F-FDG PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[18]  G. Pfurtscheller,et al.  On the realization of an analytic high-resolution EEG , 1998, IEEE Transactions on Biomedical Engineering.

[19]  J R Ives,et al.  EEG-triggered echo-planar functional MRI in epilepsy , 1996, Neurology.

[20]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[21]  R. Worth,et al.  HIPDM-SPECT in patients with medically intractable complex partial seizures. Ictal study. , 1988, Archives of neurology.

[22]  R W Cox,et al.  Real‐time 3D image registration for functional MRI , 1999, Magnetic resonance in medicine.

[23]  Robert M. Worth,et al.  Single photon emission computed tomography (SPECT) brain imaging using N,N,N′‐trimethyl‐N′‐(2 hydroxy‐3‐methyl‐5–123Iiodobenzyl)‐1,3‐propanediamine 2 HCl (HIPDM) , 1986, Neurology.

[24]  O. Markand,et al.  HIPDM Single Photon Emission Computed Tomography Brain Imaging in Partial Onset Secondarily Generalized Tonic‐Clonic Seizures , 1987, Epilepsia.

[25]  J C Depresseux,et al.  Regional cerebral blood flow and metabolic rates in human focal epilepsy and status epilepticus. , 1986, Advances in neurology.

[26]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[27]  E. Koller,et al.  The impact of cardiac activity on triaxially recorded endogenous microvibrations of the body , 2004, European Journal of Applied Physiology and Occupational Physiology.

[28]  M R Symms,et al.  EEG-triggered functional MRI of interictal epileptiform activity in patients with partial seizures. , 1999, Brain : a journal of neurology.

[29]  E C Wong,et al.  Processing strategies for time‐course data sets in functional mri of the human brain , 1993, Magnetic resonance in medicine.

[30]  Louis Lemieux,et al.  Identification of EEG Events in the MR Scanner: The Problem of Pulse Artifact and a Method for Its Subtraction , 1998, NeuroImage.

[31]  Ictal SPECT hyperperfusion reflects the activation of the symptomatogenic cortex in spontaneous and electrically-induced non-habitual focal epileptic seizures: correlation with subdural EEG recordings. , 2000, Epileptic disorders : international epilepsy journal with videotape.

[32]  T. Yousry,et al.  Ictal technetium-99m ethyl cysteinate dimer single-photon emission tomographic findings and propagation of epileptic seizure activity in patients with extratemporal epilepsies , 1998, European Journal of Nuclear Medicine.

[33]  K J Werhahn,et al.  Electroencephalography during functional echo‐planar imaging: Detection of epileptic spikes using post‐processing methods , 2000, Magnetic resonance in medicine.

[34]  D. Schauwecker,et al.  Regional Cerebral Perfusion in PLEDs: A Case Report , 1988, Epilepsia.

[35]  A M Dale,et al.  Event-related functional MRI: past, present, and future. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[36]  C M Michel,et al.  EEG‐Triggered Functional MRI in Patients With Pharmacoresistant Epilepsy , 2000, Journal of magnetic resonance imaging : JMRI.

[37]  R W Cox,et al.  Software tools for analysis and visualization of fMRI data , 1997, NMR in biomedicine.

[38]  S. Rombouts,et al.  Within-subject reproducibility of visual activation patterns with functional magnetic resonance imaging using multislice echo planar imaging. , 1998, Magnetic resonance imaging.

[39]  H. Otsubo,et al.  Focal cortical dysplasia in children with localization-related epilepsy: EEG, MRI, and SPECT findings. , 1993, Pediatric neurology.

[40]  C. Rowe,et al.  Patterns of postictal cerebral blood flow in temporal lobe epilepsy , 1991, Neurology.

[41]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[42]  R. Homan,et al.  Cerebral location of international 10-20 system electrode placement. , 1987, Electroencephalography and clinical neurophysiology.

[43]  D. Gadian,et al.  Functional magnetic resonance imaging of focal seizures , 1994, Neurology.