Soft drugs: Principles and methods for the design of safe drugs

[1]  D. Menzel,et al.  The metabolism in vivo of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion. , 1968, Biochemical pharmacology.

[2]  P. Davis,et al.  Serum beta -- lipoproteins: studies in a patient and in guinea pigs after the ingestion of organophosphorus compounds. , 1975, Clinical biochemistry.

[3]  N. Bodor,et al.  Soft drugs V: Thiazolidine-type derivatives of progesterone and testosterone. , 1982, Journal of pharmaceutical sciences.

[4]  N. Bodor,et al.  Improved delivery through biological membranes XIV: Brain-specific, sustained delivery of testosterone using a redox chemical delivery system. , 1984, Journal of pharmaceutical sciences.

[5]  R Woods,et al.  Soft drugs. 3. A new class of anticholinergic agents. , 1980, Journal of medicinal chemistry.

[6]  N. Bodor,et al.  13C NMR spectroscopy of 4,5- and 5,6-double bond isomers of spiro-3-steroidal ketone derivatives , 1981 .

[7]  N. Bodor,et al.  Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain-specific delivery of phenylethylamine. , 1983, Journal of medicinal chemistry.

[8]  N. Bodor,et al.  Soft drugs. 2. Soft alkylating compounds as potential antitumor agents. , 1980, Journal of medicinal chemistry.

[9]  S. Yalkowsky,et al.  Rationale for design of biologically reversible drug derivatives: prodrugs. , 1975, Journal of pharmaceutical sciences.

[10]  Nicholas Bodor,et al.  Designing safer drugs based on the soft drug approach , 1982 .

[11]  C. N. Habecker,et al.  Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives. , 1983, Journal of medicinal chemistry.

[12]  F S MACMILLAN,et al.  THE ANTIPERSPIRANT ACTION OF TOPICALLY APPLIED ANTICHOLINERGICS. , 1964, The Journal of investigative dermatology.

[13]  R. Colton,et al.  Photoelectron spectra, hydrolytic stability, and antimicrobial activity of N-chlorinated piperidines. , 1974, Journal of pharmaceutical sciences.

[14]  E. Dybing,et al.  Cytochrome P-450-mediated oxidation of 2-hydroxyestrogens to reactive intermediates. , 1976, Biochemical and biophysical research communications.

[15]  E. J. Ariëns.  Modulation of Pharmacokinetics by Molecular Manipulation , 1971 .

[16]  Nicholas Bodor,et al.  Soft drugs 4. 3-Spirothiazolidines of hydrocortisone and its derivatives , 1982 .

[17]  W. G. Anderson,et al.  Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function. , 1982, Journal of medicinal chemistry.

[18]  H. Laurent,et al.  Synthesis of novel anti-inflammatory steroids. , 1975, Angewandte Chemie.

[19]  N. Bodor,et al.  N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2-oxazolidinones. , 1976, Journal of pharmaceutical sciences.

[20]  N. Bodor,et al.  N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives. , 1976, Journal of pharmaceutical sciences.

[21]  N. Bodor,et al.  Redox delivery system for brain-specific, sustained release of dopamine. , 1983, Science.

[22]  N. Bodor,et al.  Acylation of the 4,5- and 5,6-double bond isomers of 3-steroidal thiazolidines: The chemical stability of spiro-3-steroidal 4,5- and 5,6-double bond isomers , 1981 .

[23]  N. Bodor,et al.  Antimicrobial activity of N-chloramine compounds. , 1980, Journal of pharmaceutical sciences.

[24]  W. M. Schubert,et al.  An Example of SN1 Cleavage of a Sulfide1 , 1965 .

[25]  R. J. Francis,et al.  Determination of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatography with electron capture detection , 1976 .

[26]  Vimal Singh.  Comment: Novel sinusoidal oscillator employing grounded capacitors , 1980 .

[27]  N. Bodor,et al.  Problems of delivery of drugs to the brain. , 1982, Pharmacology & therapeutics.

[28]  N Bodor,et al.  Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials. , 1980, Journal of medicinal chemistry.

[29]  B. Brodie,et al.  Biochemical Mechanisms of Drug Toxicity , 1974 .