Self-assembled DNA tetrahedral optofluidic lasers with precise and tunable gain control.

We have applied self-assembled DNA tetrahedral nanostructures for the precise and tunable control of the gain in an optofluidic fluorescence resonance energy transfer (FRET) laser. By adjusting the ratio of the donor and the acceptor attached to the tetrahedral vertices, 3.8 times reduction in the lasing threshold and 28-fold enhancement in the lasing efficiency were demonstrated. This work takes advantage of the self-recognition and self-assembly capabilities of biomolecules with well-defined structures and addressability, enabling nano-engineering of the laser down to the molecular level.

[1]  Wen Jiang,et al.  Exterior modification of a DNA tetrahedron. , 2010, Chemical communications.

[2]  A DNA nanostructure for the functional assembly of chemical groups with tunable stoichiometry and defined nanoscale geometry. , 2009, Angewandte Chemie.

[3]  Liguang Xu,et al.  Self-assembly of chiral nanoparticle pyramids with strong R/S optical activity. , 2012, Journal of the American Chemical Society.

[4]  Hao Yan,et al.  A DNA Nanostructure‐based Biomolecular Probe Carrier Platform for Electrochemical Biosensing , 2010, Advanced materials.

[5]  H J Moon,et al.  Cylindrical microcavity laser based on the evanescent-wave-coupled gain. , 2000, Physical review letters.

[6]  Hao Yan,et al.  Challenges and opportunities for structural DNA nanotechnology. , 2011, Nature nanotechnology.

[7]  Xudong Fan,et al.  Distinguishing DNA by analog-to-digital-like conversion by using optofluidic lasers. , 2012, Angewandte Chemie.

[8]  Christelle Monat,et al.  Integrated optofluidics: A new river of light , 2007 .

[9]  A. Hawkins,et al.  The photonic integration of non-solid media using optofluidics , 2011 .

[10]  Andrew J Turberfield,et al.  Single-molecule protein encapsulation in a rigid DNA cage. , 2006, Angewandte Chemie.

[11]  Xudong Fan,et al.  Optofluidic Microsystems for Chemical and Biological Analysis. , 2011, Nature photonics.

[12]  Thomas Tørring,et al.  DNA origami: a quantum leap for self-assembly of complex structures. , 2011, Chemical Society reviews.

[13]  N. Seeman.  DNA in a material world , 2003, Nature.

[14]  Chunhai Fan,et al.  Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors. , 2012, Angewandte Chemie.

[15]  Demetri Psaltis,et al.  Optofluidic dye lasers , 2008 .

[16]  Xudong Fan,et al.  Bioinspired optofluidic FRET lasers via DNA scaffolds , 2010, Proceedings of the National Academy of Sciences.

[17]  Xudong Fan,et al.  Highly sensitive fluorescent protein FRET detection using optofluidic lasers. , 2013, Lab on a chip.

[18]  Michael J. Campolongo,et al.  Building plasmonic nanostructures with DNA. , 2011, Nature nanotechnology.

[19]  B. Armitage,et al.  Fluorescent DNA nanotags based on a self-assembled DNA tetrahedron. , 2009, ACS nano.

[20]  A. Paul Alivisatos,et al.  Pyramidal and chiral groupings of gold nanocrystals assembled using DNA scaffolds. , 2009, Journal of the American Chemical Society.

[21]  Yi Lu,et al.  Nano-encrypted Morse code: a versatile approach to programmable and reversible nanoscale assembly and disassembly. , 2013, Journal of the American Chemical Society.

[22]  F. Simmel,et al.  DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response , 2011, Nature.

[23]  Russell P. Goodman,et al.  Reconfigurable, braced, three-dimensional DNA nanostructures. , 2008, Nature nanotechnology.

[24]  Scott Lacey,et al.  Versatile opto-fluidic ring resonator lasers with ultra-low threshold. , 2007, Optics express.

[25]  H. Pei,et al.  Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. , 2011, ACS nano.

[26]  Philip Tinnefeld,et al.  Fluorescence Enhancement at Docking Sites of DNA-Directed Self-Assembled Nanoantennas , 2012, Science.

[27]  Russell P. Goodman,et al.  Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication , 2005, Science.

[28]  D. Psaltis,et al.  Developing optofluidic technology through the fusion of microfluidics and optics , 2006, Nature.

[29]  A. Kristensen,et al.  Diffusion driven optofluidic dye lasers encapsulated into polymer chips. , 2012, Lab on a chip.

[30]  Intracavity DNA melting analysis with optofluidic lasers. , 2012, Analytical chemistry.