Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia

[1]  P. Robbins,et al.  Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Y. Kaneda,et al.  Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Seltzer,et al.  Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product , 1995, Science.

[4]  L. Zitvogel,et al.  Construction and characterization of retroviral vectors expressing biologically active human interleukin-12. , 1994, Human gene therapy.

[5]  A. Nussler,et al.  Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation. , 1994, Biochemical and biophysical research communications.

[6]  P. Armstrong,et al.  Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. , 1994, Circulation research.

[7]  J. Lancaster,et al.  Simulation of the diffusion and reaction of endogenously produced nitric oxide. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[8]  E. Nabel,et al.  Gene therapy for vascular smooth muscle cell proliferation after arterial injury. , 1994, Science.

[9]  G. Hansson,et al.  Arterial smooth muscle cells express nitric oxide synthase in response to endothelial injury , 1994, The Journal of experimental medicine.

[10]  T. Billiar,et al.  New insights into the regulation of inducible nitric oxide synthesis. , 1994, The American journal of physiology.

[11]  P. Davies,et al.  Peripheral and central vascular smooth muscle cells from rat lung exhibit different cytoskeletal protein profiles but similar growth factor requirements , 1994, Journal of cellular physiology.

[12]  H. Kagamiyama,et al.  Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle. , 1994, The American journal of physiology.

[13]  G. Miotto,et al.  Multiphasic control of proteolysis by leucine and alanine in the isolated rat hepatocyte. , 1994, The American journal of physiology.

[14]  J. Isner,et al.  Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury. , 1994, The Journal of clinical investigation.

[15]  M. Davies,et al.  Reduction of experimental vein graft intimal hyperplasia and preservation of nitric oxide-mediated relaxation by the nitric oxide precursor L-arginine. , 1994, Surgery.

[16]  D. Benos,et al.  Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells. , 1994, The American journal of physiology.

[17]  K. Baek,et al.  Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. , 1993, The Journal of biological chemistry.

[18]  K. Croen,et al.  Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. , 1993, The Journal of clinical investigation.

[19]  L. Ignarro,et al.  L-arginine inhibits balloon catheter-induced intimal hyperplasia. , 1993, Biochemical and biophysical research communications.

[20]  R. Ross.  The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[21]  S H Snyder,et al.  Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[22]  E. Jaffee,et al.  Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[23]  J. Feely,et al.  Endothelium derived relaxing factor is absent in experimental in situ vein grafts. , 1993, European Journal of Vascular Surgery.

[24]  C. Lowenstein,et al.  Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  G. Nolan,et al.  Production of high-titer helper-free retroviruses by transient transfection. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Michael Simons,et al.  Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo , 1992, Nature.

[27]  O. Danos.  Construction of Retro viral Packaging Cell Lines. , 1992, Methods in molecular biology.

[28]  P. Kubes,et al.  Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. Billiar,et al.  Nitric oxide and nitric oxide‐generating compounds inhibit hepatocyte protein synthesis , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  E. Werner,et al.  Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts , 1990, The Journal of experimental medicine.

[31]  M. Yacoub,et al.  Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries , 1990, The Lancet.

[32]  A. Quyyumi,et al.  Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. , 1990, The New England journal of medicine.

[33]  R. Busse,et al.  Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin , 1990, FEBS letters.

[34]  T. Lüscher,et al.  Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. , 1990, Circulation.

[35]  B. Mayer,et al.  Biosynthesis of endothelium-derived relaxing factor: a cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase. , 1989, Biochemical and biophysical research communications.

[36]  H. Baumgartner,et al.  Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. , 1989, Science.

[37]  A. Hassid,et al.  Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. , 1989, The Journal of clinical investigation.

[38]  D. Stuehr,et al.  An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro , 1989, The Journal of experimental medicine.

[39]  R. Mulligan,et al.  Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[40]  L. Ignarro,et al.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[42]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[43]  C. Cepko,et al.  Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[44]  L. Ignarro,et al.  Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. , 1981, Blood.

[45]  U. K. Laemmli,et al.  Cleavage of structural proteins during , 1970 .

[46]  S. Kaufman.  THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR. , 1962, Proceedings of the National Academy of Sciences of the United States of America.