论文信息 - The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos

The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos

The lathyrogenic effect of 2·5 mg of β‐aminopropionitrile in the chick embryo has been measured by the increase in the extractability of collagen from bones using M saline. Sodium salicylate (3 mg/embryo) and hydrocortisone (1·5 mg/embryo) applied 24 hr after the injection of β‐aminopropionitrile decreased the elevated amount of soluble collagen. Phenylbutazone, chloroquine diphosphate and sodium aurothiosulphate were ineffective in this experimental system.

K. Trnavský | Z. Trnavská

[1] R. Page,et al. Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile. , 1967, Biochemistry.

[2] R. M. Johnson,et al. Effect of calcium on the incorporation of proline into hydroxyproline of collagen fractions from normal and lathyritic chick embryos. , 1965, Poultry science.

[3] C. Levene,et al. Fragility and Extractable Collagen in the Lathyritic Chick Embryo. An Assay for Lathyrogenic Agents.∗ , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[4] C. Levene,et al. ALTERATIONS IN STATE OF MOLECULAR AGGREGATION OF COLLAGEN INDUCED IN CHICK EMBRYOS BY β-AMINOPROPIONITRILE (LATHYRUS FACTOR) , 1959, The Journal of experimental medicine.

[5] I. Ponseti. Studies of the suppression of aminonitrile lesions in rats by throxine analogues. , 1959, Endocrinology.

[6] P. Iwangoff,et al. [STUDIES ON THE METABOLISM OF COLLAGEN. II. THE INCORPORATION OF (14C)GLYCINE IN COLLAGEN IN PREDNISONE-TREATED RATS]. , 1964, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[7] Marc S. Lewis,et al. The incorporation of [14C]glycine into the subunits of collagens from normal and lathyritic animals , 1963 .

[8] H. Stegemann. [Microdetermination of hydroxyproline with chloramine-T and p-dimethylaminobenzaldehyde]. , 1958, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.