NRF2-targeted therapeutics: New targets and modes of NRF2 regulation.
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Donna D. Zhang | Montserrat Rojo de la Vega | E. Chapman | M. Dodson | Montserrat Rojo de la Vega | Matthew Dodson | Eli Chapman | Donna D. Zhang
[1] L. Cai,et al. The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome , 2015, Reviews in Endocrine and Metabolic Disorders.
[2] James Lee,et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis , 2015, Molecular & Cellular Proteomics.
[3] G. Baillie,et al. PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding. , 2014, Biochimica et biophysica acta.
[4] K. Itoh,et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.
[5] Donna D. Zhang,et al. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism , 2011, Proceedings of the National Academy of Sciences.
[6] W. Zong,et al. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. , 2016, Molecular cell.
[7] T. Nakajima,et al. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis , 2014, Genes & development.
[8] A. Cuadrado,et al. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. , 2012, Oncogene.
[9] T. Mizushima,et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. , 2013, Molecular cell.
[10] Q. You,et al. Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. , 2014, Journal of medicinal chemistry.
[11] Mihee M. Kim,et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 , 2010, Nature Cell Biology.
[12] G. Wells. Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction. , 2015, Biochemical Society transactions.
[13] L. Wattenberg. Inhibitors of chemical carcinogenesis. , 1978, Advances in cancer research.
[14] J. Garcia,et al. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner , 2016, Scientific Reports.
[15] Myungjin Kim,et al. Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1 , 2014, The FEBS journal.
[16] Joachim Kraemer,et al. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. , 2013, Bioorganic & medicinal chemistry.
[17] Steven B. Bradfute,et al. TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation. , 2012, Immunity.
[18] B. Levine,et al. Autosis and autophagic cell death: the dark side of autophagy , 2014, Cell Death and Differentiation.
[19] A. Kong,et al. Optimization of Fluorescently Labeled Nrf2 Peptide Probes and the Development of a Fluorescence Polarization Assay for the Discovery of Inhibitors of Keap1-Nrf2 Interaction , 2012, Journal of biomolecular screening.
[20] T. Kensler,et al. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. , 2016, Seminars in oncology.
[21] Donna D. Zhang,et al. The emerging role of the Nrf2–Keap1 signaling pathway in cancer , 2013, Genes & development.
[22] S. Sehgal. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. , 1998, Clinical biochemistry.
[23] A. Kong,et al. Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis , 2010, Cancer and Metastasis Reviews.
[24] M. McMahon,et al. p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription* , 2010, The Journal of Biological Chemistry.
[25] She Chen,et al. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy , 2010, Autophagy.
[26] K. Ward,et al. Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers , 2015, BMC Dermatology.
[27] W. Zong. Corrections to "TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis "[Molecular Cell 61, 720-733; March 3, 2016] , 2016 .
[28] Donna D. Zhang,et al. The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells , 2010, Molecules.
[29] I. Benjamin,et al. Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. , 2013, Antioxidants & redox signaling.
[30] Hye Eun Lee,et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.
[31] J. Hayes,et al. Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction. , 2012, Free radical biology & medicine.
[32] Nadine H. Elowe,et al. An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase , 2010, Nature Biotechnology.
[33] P. Wong,et al. Dual roles of Nrf2 in cancer. , 2008, Pharmacological research.
[34] Ken Itoh,et al. Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron* , 2004, Journal of Biological Chemistry.
[35] D. Arnold,et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. , 2012, The New England journal of medicine.
[36] Mark Hannink,et al. Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex , 2004, Molecular and Cellular Biology.
[37] P. Rada,et al. Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3. , 2012, Free radical biology & medicine.
[38] Bob van de Water,et al. The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.
[39] Donna D. Zhang. Bardoxolone brings Nrf2-based therapies to light. , 2013, Antioxidants & redox signaling.
[40] Q. You,et al. Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening , 2014 .
[41] E. White,et al. A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62 , 2010, Molecular and Cellular Biology.
[42] C. Wolf,et al. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha , 2007, Proceedings of the National Academy of Sciences.
[43] Y. Li,et al. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor , 2010, Nature Biotechnology.
[44] J. D. Engel,et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.
[45] S. Lipton,et al. Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. , 2013, Free radical biology & medicine.
[46] T. Hoffmann,et al. Peptide therapeutics: current status and future directions. , 2015, Drug discovery today.
[47] J. Callahan,et al. Keap calm, and carry on covalently. , 2013, Journal of medicinal chemistry.
[48] P. Rada,et al. SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner , 2011, Molecular and Cellular Biology.
[49] P. Talalay,et al. Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants. , 1978, Cancer research.
[50] S. Schreiber,et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. , 2013, Bioorganic & medicinal chemistry letters.
[51] A. Limonciel,et al. A Review of the Evidence that Ochratoxin A Is an Nrf2 Inhibitor: Implications for Nephrotoxicity and Renal Carcinogenicity , 2014, Toxins.
[52] N. Nukina,et al. Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins. , 2011, Molecular cell.