Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH.

[1]  Masato Tanaka,et al.  CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. , 2017, JCI insight.

[2]  S. Pyne,et al.  Sphingosine 1-phosphate and cancer. , 2017, Advances in biological regulation.

[3]  J. González‐Gallego,et al.  Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy , 2017, Front. Pharmacol..

[4]  M. Maceyka,et al.  Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology , 2017, Critical reviews in biochemistry and molecular biology.

[5]  Lixin Sun,et al.  The role of sphingosine 1‐phosphate receptor 2 in bile‐acid–induced cholangiocyte proliferation and cholestasis‐induced liver injury in mice , 2017, Hepatology.

[6]  K. Tsuchiya,et al.  Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis , 2017, Scientific Reports.

[7]  V. Shah,et al.  Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis. , 2017, American journal of physiology. Gastrointestinal and liver physiology.

[8]  L. Henry,et al.  Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes , 2016, Hepatology.

[9]  D. Mukhopadhyay,et al.  Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration* , 2015, The Journal of Biological Chemistry.

[10]  N. Ohkohchi,et al.  Sphingosine 1‐phosphate has anti‐apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.

[11]  S. Spiegel,et al.  Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression , 2015, Hepatology.

[12]  J. Kornhuber,et al.  Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. , 2014, Biochimica et biophysica acta.

[13]  S. Terai,et al.  Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans , 2013, PloS one.

[14]  Y. Hannun,et al.  Sphingosine‐1‐phosphate receptor 2 , 2013, The FEBS journal.

[15]  Shelly C. Lu,et al.  Excess S‐adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis , 2013, Hepatology.

[16]  S. Terai,et al.  Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis. , 2011, The American journal of pathology.

[17]  Shelly C. Lu,et al.  Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice , 2007, Hepatology.

[18]  Masafumi Takahashi,et al.  Sphingosine-1-phosphate receptor agonists suppress concanavalin A-induced hepatic injury in mice. , 2006, Biochemical and biophysical research communications.

[19]  R. Schwabe,et al.  Roles for C16-ceramide and Sphingosine 1-Phosphate in Regulating Hepatocyte Apoptosis in Response to Tumor Necrosis Factor-α* , 2005, Journal of Biological Chemistry.

[20]  T. Hla,et al.  Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. , 2002, Biochimica et biophysica acta.

[21]  B. Friedman,et al.  Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3* , 2001, The Journal of Biological Chemistry.

[22]  A. Sanyal,et al.  A Lipidomic Readout of Disease Progression in A Diet-Induced Mouse Model of Nonalcoholic Fatty Liver Disease. , 2015, Transactions of the American Clinical and Climatological Association.