Familial multiple pilomatrixomas

reported in association with G-CSF therapy. The histology of our case showed a mixed inflammatory infiltrate around the hair follicles consisting principally of lymphocytes and histiocytes. with occasional neutrophils and eosinophils. Our patient is unusually sensitive to G-CSF and requires only monthly subcutaneous injections to maintain an adequate neutrophil count. The development of new skin lesions always occurs within 24 h of (5-CSF therapy, thus strongly implicating it in the pathogenesis ofthe rash.