Prevalence of Hypomagnesaemia in Children Admitted to the Pediatric Intensive Care Unit and its Related Factors in Zahedan, Iran

Background: Clinical status of children admitted to the intensive care units (ICUs) is important. We aimed to investigate prevalence of hypomagnesaemia in children admitted to the pediatric intensive care unit (PICU), and its relation factors. Materials and Methods: This cross-sectional study was conducted in Ali Ebne Abitalib Hospital Zahedan, Iran, in 2018. From total children who were admitted to the PICU, 150 individuals aged one month to 12 years that were entered to the study. Magnesium level was estimated by XYLIDYL BLUE method using Erba kits. Children were divided into two groups based on their serum magnesium concentration defined as normal and abnormal. Data were analyzed using SPSS software version 18.0. Results: From 150 admitted children to the PICU, 44.7% were hypomagnesaemia with longer hospital stay, higher levels of Na, K and Ca (p>0.05). During the first five day of hospitalization, 58 children died, most of them were hypomagnesaemia. About 39.6% of 101 children who consumed diuretic medicine were hypomagnesemia. This pattern was 43.8% and 40.00% from 130 and 85 patients who used digital or aminoglycoside medicines. About half of the children who had heart diseases were hypomagnesemia. These trends were 33.3% in kidney and sepsis; about 50.00% and 43.5% were hypomagnesaemia from those who had central nervous disorder and respiratory problems, respectively. The eldest children had 1.79 times higher odds (95% CI=0.76 to 8.30) to be hypomagnesaemia compared to the youngest, and girls had 1.01 times higher odds (95% CI=0.44 to 2.30) to be hypomagnesaemia. Conclusion: Prevalence of hypomagnesaemia in children admitted to the PICU was high and it was associated with the major electrolytes of sodium, potassium, and calcium.

[1]  A. Saleem,et al.  Electrolyte imbalance in critically ill paediatric patients , 2019, Pakistan journal of medical sciences.

[2]  V. Ratageri,et al.  Prevalence of hypomagnesemia in children admitted to pediatric intensive care unit and its correlation with patient outcome , 2019, International Journal of Contemporary Pediatrics.

[3]  Seher Erdoğan,et al.  Hyopomagnesemia in Critically Ill Children , 2018, Iranian Journal of Pediatrics.

[4]  S. Save,et al.  Study of association of mortality with electrolyte abnormalities in children admitted in pediatric intensive care unit , 2018 .

[5]  M. Taghipour,et al.  Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit , 2017 .

[6]  C. Pierrakos,et al.  Hypomagnesemia in Critically Ill Sepsis Patients , 2015, Journal of clinical medicine research.

[7]  Q. Qian,et al.  Dysmagnesemia in Hospitalized Patients: Prevalence and Prognostic Importance. , 2015, Mayo Clinic proceedings.

[8]  A. Haque,et al.  On admission hypomagnesemia in critically ill children: Risk factors and outcome , 2009, Indian journal of pediatrics.

[9]  J. Kaur,et al.  Improvement in electrolyte imbalance in critically ill patient after magnesium supplementation — A case report , 2009, Indian Journal of Clinical Biochemistry.

[10]  R. Mogulkoc,et al.  Adrenocorticotropic Hormone and Cortisol Levels in Athletes and Sedentary Subjects at Rest and Exhaustion: Effects of Magnesium Supplementation , 2008, Biological Trace Element Research.

[11]  M. Safavi,et al.  Admission hypomagnesemia--impact on mortality or morbidity in critically ill patients. , 2007, Middle East journal of anaesthesiology.

[12]  C. Wagner Disorders of renal magnesium handling explain renal magnesium transport. , 2007, Journal of nephrology.

[13]  Melvin H. Williams Dietary Supplements and Sports Performance: Amino Acids , 2005, Journal of the International Society of Sports Nutrition.

[14]  R. Rude,et al.  Magnesium Deficiency in Critical Illness , 2005, Journal of intensive care medicine.

[15]  H. M. Soliman,et al.  Development of ionized hypomagnesemia is associated with higher mortality rates , 2003, Critical care medicine.

[16]  G. Matuschak,et al.  Magnesium in critical illness: metabolism, assessment, and treatment , 2002, Intensive Care Medicine.

[17]  B. Thomas,et al.  Electrolyte abnormalities in children admitted to pediatric intensive care unit. , 2000, Indian pediatrics.

[18]  C. Pak Correction of thiazide-induced hypomagnesemia by potassium-magnesium citrate from review of prior trials. , 2000, Clinical nephrology.

[19]  E. Mannick,et al.  Syndrome of Hypokalemic Metabolic Alkalosis and Hypomagnesemia Associated with Gentamicin Therapy: Case Reports , 2000, Clinical pediatrics.

[20]  S. Rane,et al.  Hypomagnesaemia in paediatric population in an intensive care unit. , 2000, Journal of Postgraduate Medicine.

[21]  Dr. B. Shalini,et al.  Correlation Between Serum Electrolytes And Clinical Outcome in Children Admitted To PICU , 2017 .

[22]  G. Hauser,et al.  Electrolyte Disorders in the PICU , 2014 .

[23]  V. Londhey,et al.  Hypomagnesemia in critically ill medical patients. , 2011, The Journal of the Association of Physicians of India.

[24]  I. Cojocaru,et al.  Changes of magnesium serum levels in patients with acute ischemic stroke and acute infections. , 2009, Romanian journal of internal medicine = Revue roumaine de medecine interne.

[25]  V. Martínez-Vizcaíno,et al.  Total and ionized serum magnesium in critically ill patients , 2004, Intensive Care Medicine.

[26]  M. Syczewska,et al.  [Reasons for magnesium deficiency in children with coeliac disease]. , 2001, Wiadomosci lekarskie.